Tumor Hypoxia
Targeting Tumor Hypoxia Using Nanoparticle-engineered CXCR4-overexpressing Adipose-derived Stem Cells
... tissue hypoxia, strongly induces expression of SDF-1α in cancer cells, and SDF-1α is correlated with increasing tumor cell motility and ...toward tumor tissues in ...targeting tumor ...
11
Tumor Hypoxia Mutation Detection Using Deep Learning-A Deep Drug Designing Strategy
... Abstract: Tumor hypoxia develops as an adaptation taken up by the cancer cells during prolonged radiation and ...The tumor microenvironment is set up as a result of mutations occurred in ...
5
An Activatable Near-Infrared Chromophore for Multispectral Optoacoustic Imaging of Tumor Hypoxia and for Tumor Inhibition
... the tumor region of the mouse injected with NR-azo was much stronger compared to that in the healthy ...solid tumor on the mice’s back more directly and ...to tumor hypoxia and can serve as a ...
12
Relief of tumor hypoxia unleashes the tumoricidal potential of neutrophils
... improve tumor oxygenation, we provide in vivo evidence that hypoxia exerts a powerful but complex influence over tumor-associated PMN behavior and ...that hypoxia promoted PMN recruitment to ...
16
Evaluation of tumor hypoxia and proliferation in canine spontaneous solid tumors
... to tumor hypoxia can be effectively eliminated. Hypoxia-targeted therapy can be an excellent strategy to improve treatment outcome without excessive normal tissue toxicity (Brown, ...for ...
231
Overcoming tumor hypoxia as a barrier to radiotherapy, chemotherapy and immunotherapy in cancer treatment
... Abstract: Hypoxia exists to some degree in most solid tumors due to inadequate oxygen delivery of the abnormal vasculature which cannot meet the demands of the rapidly proliferating cancer ...same tumor are ...
10
Elimination of tumor hypoxia by eribulin demonstrated by 18F-FMISO hypoxia imaging in human tumor xenograft models
... the hypoxia imaging technique with 18 F-FMISO, we directly demon- strated the elimination of the tumor hypoxic condition by eribulin ...increase tumor hypoxia by inhibition of angio- ...to ...
10
Tumor Hypoxia Regulates Forkhead Box C1 to Promote Lung Cancer Progression
... in tumor progression. However, the role of tumor hypoxia in FOXC1 regulation and its impact on lung cancer progression are ...Moreover, hypoxia activated FOXC1 transcription via direct binding ...
15
Long non-coding RNA and tumor hypoxia: new players ushered toward an old arena
... in Tumor) and HIF1A-AS2 (HIF1A Antisense RNA 2; also known as aHIF) have both been implicated in both negative regu- lation of HIF1A mRNA ...of hypoxia-responsive lncRNAs reported, lncRNA-LET ex- pression ...
19
One stop shop tumor imaging: buy hypoxia, get lactate free
... carcinoma tumor–bearing mice (see the related article beginning on page ...control tumor hypoxia and metabolism and may have future clinical potential for monitoring tumor response to ...
5
Current research progress on hypoxia and tumor
... of tumor cells, but also changes the tumor cells themselves, making them more suitable for tumor survival and growth in tumor ...metastatic tumor cells can escape immune surveillance in ...
7
The Role of the Transcription Factor atF4iin Tumor Progression Under Nutrient Deprivation and Hypoxia
... of tumor cells compared to normal cells (Jones and Thompson, ...Clinically, tumor hypoxia is a significant obstacle to therapy. Hypoxic tumor cells are more resistant to ionizing radiation ...
109
Self-generating oxygen enhanced mitochondrion-targeted photodynamic therapy for tumor treatment with hypoxia scavenging
... hypoxic tumor microenvironment, as revealed by ROS/hypoxia imaging in vitro and PA imaging in ...of tumor hypoxia has also been proven to enhance PDT effects and prevent tumor ...
15
Prevention of hypoxia by myoglobin expression in human tumor cells promotes differentiation and inhibits metastasis
... no hypoxia, minimal HIF-1a levels, and a homogeneously low vessel ...Mb-mediated tumor oxygenation promoted differentiation of cancer cells and suppressed both local and distal metastatic ...reduced ...
12
Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids
... conditions, tumor cells undergo a series of adaptations that promote evolution of a more aggressive tumor phenotype including the activation of DNA damage repair proteins, altered metabolism, and decreased ...
10
<p>Multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guided tumor therapy</p>
... Abstract: Hypoxia is a common feature of most solid ...of tumor hypoxia condition is a key to tumor ...Many hypoxia imaging nanoparticles have been used for tumor ...optical ...
13
Overcoming hypoxia-induced chemoresistance to cisplatin through tumor oxygenation monitored by optical imaging
... PFC-based tumor oxygenation to improve radiation and photodynamic therapy in pre-clinical animal models [11–15], but limited effort has been applied toward its use in ...chemotherapy. Tumor oxygenation ...
13
Tf-PEG-PLL-PLGA nanoparticles enhanced chemosensitivity for hypoxia-responsive tumor cells
... of hypoxia on the growth- inhibitory effects of ...were hypoxia responsive and resulted in drug ...that hypoxia downregulates drug sensitivity of tumor cells to chemotherapeutic ...
11
Hypoxia inducible factor 2α regulates macrophage function in mouse models of acute and tumor inflammation
... Loss of TAM HIF-2α leads to reduced tumor burden and progression in murine CAC. (A and B) Control (Δ/+) and mutant (Δ/Δ) mice were induced to form CAC for 14 weeks, and gross pictures of tumors in the colon and ...
17
Hypoxia-induced CCL28 promotes recruitment of regulatory T cells and tumor growth in liver cancer
... liver tumor cells overcome disadvantaged hypoxic microenvironment by upregulating expression of CCL28 to recruit a specific Treg population at the tumor ...in tumor microenvironment crafting during ...
11