Tumor-infiltrating immune cell
Tumor infiltrating immune cell profiles and their change after neoadjuvant chemotherapy predict response and prognosis of breast cancer
... even immune-related signatures ...of tumor immune surveillance, while CD4 lymphocytes either have not been evaluated or have been associated with suppression of anti-tumor im- mune ...and ...
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Tumor-infiltrating immune cell subpopulations influence the oncologic outcome after intravesical Bacillus Calmette-Guérin therapy in bladder cancer
... TAMs infiltrating cancer cells and an increased cancer cell-to-lamina propria TAM ratio were associated with a poor oncologic outcome after BCG [18, ...the tumor stroma and lamina ...in tumor ...
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Comprehensive analyses of tumor immunity: implications for cancer immunotherapy
... of tumor immune infiltration We developed a computational method to estimate the abundance of six tumor-infiltrating immune cell types (B cells, CD4 T cells, CD8 T cells, ...
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Tumor-infiltrating B cells signal functional humoral immune responses in breast cancer
... B cell immune functions extend well beyond being factories for antibody production to include cyto- kine production, antigen presentation, costimulation, and participation in the development of lymphoid ...
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Characterizing the immune microenvironment of malignant peripheral nerve sheath tumor by PD-L1 expression and presence of CD8+ tumor infiltrating lymphocytes
... includes tumor specimens from 86 patients collected between 1982 and 2009 at a single ...T cell infiltration was essentially limited to MPNST with minimal infiltration in normal nerve and benign ...
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Identification of 3 subpopulations of tumor-infiltrating immune cells for malignant transformation of low-grade glioma
... Tumor-infiltrating immune cells (TIICs), whose function and composition subtly altered with the immune status of the host have been reported to be effectively targeted by drugs correlate with ...
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Tumor infiltrating leukocyte density is independent of tumor grade and molecular subtype in aggressive breast cancer of Western Kenya
... of immune cells local- ized to breast tumors may trigger aberrant immune re- sponses in these ...recruited immune cells to the tumors may vary between cancer subtypes, suggesting that different ...
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<p>Significance of Tumor-Infiltrating Immune Cells in the Prognosis of Colon Cancer</p>
... remaining immune cells exhibited no differential in fi ltration between normal and colon cancer tissues ...5 immune cells statistically correlated with colon cancer-related survival risk, including B cells ...
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Tumor infiltrating myeloid cells induce tumor cell resistance to cytotoxic T cells in mice
... induce tumor-specific immune responses, in particular CTL responses, in many patients ...human tumor cells with PNT or with MDSCs inhibits binding of processed peptides to tumor ...
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Characterization of tumor infiltrating Natural Killer cell subset
... The reason for abundance of dNK cells in early pregnancy is unknown. Two possible explanations have been proposed for the paradox of attracting large numbers of potentially cytolytic cells to the feto-maternal interface. ...
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Checkpoint blockade in solid tumors and B-cell malignancies, with special consideration of the role of CD200
... multiple immune checkpoint molecules were expressed in tumor-associated or tumor-infiltrating cells in ovarian tumor-bearing mice and that blockade of any one of PD-1, LAG-3, or CTLA-4 ...
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Development and validation of a molecular prognostic index of bladder cancer based on immunogenomic landscape analysis
... to immune cell infiltration, and found that higher infiltrat- ing percentage of macrophages M0, macrophages M2 and neutrophils were significantly associated with the poor prognosis of BCa, while lower ...
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Prognostic impact of immune gene expression signature and tumor infiltrating immune cells in localized clear cell renal cell carcinoma
... intra-tumoral immune cell infiltrates (lymphocytes, plasma cells, macro- phages, neutrophils) on recurrence in patients with local- ized renal cell carcinoma (RCC) have produced conflicting ...the ...
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Single-cell RNA sequencing reveals compartmental remodeling of tumor-infiltrating immune cells induced by anti-CD47 targeting in pancreatic cancer
... Single-cell RNA-seq revealed five distinct clusters of macrophages (Mac_s1, Mac_s2, Mac_s3, Mac_s4, Mac_s5) (Fig. 5a). Following anti-CD47 treatment, the number and proportion of Mac_s1 and Mac_s2 cells were ...
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Consistency of tumor and immune cell programmed cell death ligand-1 expression within and between tumor blocks using the VENTANA SP263 assay
... non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC) and urothelial carcinoma (UC) tissue samples (five samples per tumor type) were obtained from commercial sources and ...
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OX40 expression enhances the prognostic significance of CD8 positive lymphocyte infiltration in colorectal cancer
... CRC included in the TMA under investigation were infiltrated to different extents by OX40+ cells (Figure 2A). Clinical-pathological characteristics of training and a validation subset did not significantly differ ...
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Sunitinib-induced morpho-functional changes and drug effectiveness in malignant solitary fibrous tumours
... preserves cell homeostasis, but also shapes cell immunity and influences the differentiation and activation of myeloid and lymphoid cells [30]; ii) sunitinib has strong immunomodulating effects on the ...
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CONGENITAL MESOBLASTIC NEPHROMA OF INFANCY
... Note the bands of tumor infiltrating the kidney parenchyma at the.. top.[r] ...
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Interleukin-21 sustains inflammatory signals that contribute to sporadic colon tumorigenesis
... of Th1-associated molecules positively correlates with reduced recurrence of sporadic CRC [29], whereas accumulation of Th17 cells impacts negatively on the prognosis of patients with such a neoplasia [17, 18]. We ...
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The diagnostic and prognostic value of MRP8/MRP14 in intrahepatic cholangiocarcinoma
... in tumor progression and cancer metastasis ...and infiltrating leukocytes, as well as bone marrow-derived myeloid cells, including macrophages, neutrophils, mast cells, myeloid cell- derived ...
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