Tumor mutation burden (TMB)
Prediction of tumor mutation burden in breast cancer based on the expression of ER, PR, HER-2, and Ki-67
... immunogenic tumor cells by somatic evolution and protecting the host from tumor development in the host immune ...or tumor mutation burden (TMB) were associated with ...
7
Significance of tumor mutation burden combined with immune infiltrates in the progression and prognosis of ovarian cancer
... The tumor mutation burden (TMB) refers to the total number of replacement and insertion/deletion (indel) mutations per basic group in the exon coding region of the assessed gene in the genome ...
11
Tumor mutation burden and circulating tumor DNA in combined CTLA-4 and PD-1 antibody therapy in metastatic melanoma – results of a prospective biomarker study
... the tumor cell surface was shown not to be a reliable pre- dictive biomarker for response or survival as checkpoint inhibitors also are effective in patients with PD-L1 nega- tive tumors ...a tumor that ...
15
Prognostic impact of tumor mutation burden and the mutation in KIAA1211 in small cell lung cancer
... expression, tumor mutation burden (TMB) is regarded as a biomarker of the efficacy of programmed death 1 (PD-1) inhibitors in various ...between TMB and progno- sis in SCLC is still ...
10
Tumor mutation burden: from comprehensive mutational screening to the clinic
... for TMB evaluation favors NSG over WES and evaluation of surrogate biomarkers for technical and practical rea- sons, standards have not been established for gene panels used in NSG ...of TMB assessment on ...
10
<p>Assessment of tumor mutation burden calculation from gene panel sequencing data</p>
... highly mutation frequencies in at least ten cancer ...highest mutation frequencies (270/399) in COAD and BRAF was most frequently mutated (228/467) in the SKCM than the other cancer ...the mutation ...
9
Epigenetic alterations are associated with tumor mutation burden in non-small cell lung cancer
... low TMB groups, we found that high TMB patient samples con- tain more DMPs (Pearson correlation coefficient = ...low TMB patient samples ...of tumor mutation data and DNA methylation ...
11
<p>Recurrent Metastatic Penile Cancer Patient with Positive PD-L1 Expression Obtained Significant Benefit from Immunotherapy: A Case Report and Literature Review</p>
... and TMB evaluation were conveyed as previously described. 5 TMB was de fi ned as the total non-silent somatic mutation counts in coding ...a tumor mutation burden (TMB) of ...
6
Case report: mutation analysis of primary pulmonary lymphoepithelioma-like carcinoma via whole-exome sequencing
... s tumor tissue and leukocytes (served as a germline mutation control) revealed 613 somatic gene mutations, and of which mutations in PRIM2, KCNB1, CDH1, and ATRX were most likely related to the LELC ...a ...
6
Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden
... that tumor mutation burden calculated using a ...of TMB, and this will especially be important in patients from ethnic backgrounds not well represented in sequencing ...of TMB at a ...
14
Inhibitory Potential of Rosmarinus Officinalis Against DMBA-Induced Skin Papillomagenesis and Modulation of Anti- Oxidant Defence System in Mice
... in tumor incidence, tumor burden, tumor multiplicity and cumulative number of papillomas along with the significant increase in the average latent period was recorded in mice treated orally ...
12
<p>Whole exome sequencing of multiple meningiomas with varying histopathological presentation in one patient revealed distinctive somatic mutation burden and independent clonal origins</p>
... somatic burden. However, the grade II tumor exhibited a high level of genomic instability and mutations of ADAMTSL3 and CAPN5, which might explain its more aggressive biological ...
11
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of non-small cell lung cancer (NSCLC)
... Cancer immunotherapy is a treatment modality used to mobilize the immune system to recognize and destroy cancer cells [11–13]. Immune checkpoint inhibitors have been developed to target self-tolerance pathways that are ...
15
<p>Hyperprogressive Disease In Cervical Small Cell Carcinoma Treated By Immune Checkpoint Inhibitor</p>
... in tumor burden compared to pre-immu- notherapy imaging, and >2-fold increase in ...Accelerated tumor growth could be associated with the blockade of PD-1/PD-L1 signaling pathway in combination ...
5
PD-L1 expression and tumor mutational burden are independent biomarkers in most cancers
... on tumor cells or tumor-infiltrating immune cells by immunohistochemistry (IHC) has become the most widely used biomarker for selecting patients for ICI therapy ...
11
Prognostic value of tumor burden in nasopharyngeal carcinoma
... that tumor burden has a significant prog- nostic value for NPC patients treated with intensity-modulated ...Hence, tumor burden, including TV and NV, should be incorporated into the current ...
7
Noninvasive detection of tumor-associated mutations from circulating cell-free DNA in hepatocellular carcinoma patients by targeted deep sequencing
... of tumor- associated somatic mutation in plasma could be used to predict clinical outcome in the patients with HCC who received surgical ...of tumor recurrence, or for up to 600 ...with ...
10
Marrow cytometry and prognosis in myeloma
... marrow tumor involvement and RNA index, suggesting a more aggressive behavior of myeloma in patients with a low tumor cell RNA ...high tumor cell RNA content identified patients with a high ...
10
Age-related somatic mutations in the cancer genome
... generate more whole-genome sequencing information, not only allowing confirmation of the accuracy of our results but also a more comprehensive analysis of patterns of mutations across the genome. Meanwhile, the observed ...
9
Monitoring Breast Tumor Lung Metastasis by U-SPECT-II/CT with an Integrin αvβ3-Targeted Radiotracer 99mTc-3P-RGD2
... circulating tumor cells in a constitu- tively activated functional form or in a state that al- lows rapid activation under blood flow conditions provides advantages for breast cancer ...
12