Tumor necrosis factor-a
Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease
... [24]. Tumor necrosis factor-a (TNF-a) is one of the major inflammatory cytokines produced by acti- vated astrocytes and ...nuclear factor Table 2 Correlations between baseline CSF levels ...
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Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet activating factor
... necrosis of the gastrointestinal tract. The morphological changes of TNF-induced bowel lesions are indistinguishable from those caused by PAF. The mechanism of TNF-induced bowel necrosis is unclear. In the ...
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Cellular Responses to Tumor Necrosis Factor
... and necrosis are initiated by TNF receptor I (TNF-RI) clustering and TRADD recruitment (Boldin et ...TNF-induced necrosis (Holler et ...and necrosis (Kane et ...and necrosis (Wang et ...or ...
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Effect of Tumor Necrosis Factor on Body Systems
... Tumor necrosis factor (TNF) is the prototypic member of a large cytokine family having two main types, tumor necrosis factor-alpha (TNF-α) and tumor necrosis ...
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The role of human T lymphocyte monocyte contact in inflammation and tissue destruction
... system, IFN-γ alone displays weak activation capacity in terms of IL-1 β and tumor necrosis factor (TNF)- α induc- tion, suggesting that soluble factors produced by T cells are not pathological ...
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Characterization in vitro of a human tumor necrosis factor binding protein A soluble form of a tumor necrosis factor receptor
... Results from biosynthetic labeling of cells with 35S-cysteine followed by immunoprecipitation with anti-TNF-BP indicated that TNF-BP is formed and released at the cell surface by cleavag[r] ...
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The Role of Death Domains Superfamily in Multiple Sclerosis Pathogenesis
... transcription factor c-jun to induce inflam- matory ...(Tumor necrosis factor), TNFR1 (Tumor necrosis factor receptor 1), TRADD (TNFR-associated death domain), TRAF 2 ...
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Comparative effectiveness and safety of rituximab versus subsequent anti–tumor necrosis factor therapy in patients with rheumatoid arthritis with prior exposure to anti–tumor necrosis factor therapies in the United States Corrona registry
... (rheumatoid factor (RF) seroposi- tivity, duration of RA, American Rheumatism Associ- ation functional class, tender and swollen joint counts, patient and provider global assessments, patient pain and functional ...
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Role of Eosinophils and Tumor Necrosis Factor Alpha in Interleukin 25 Mediated Protection from Amebic Colitis
... ABSTRACT The parasite Entamoeba histolytica is a cause of diarrhea in infants in low-income countries. Previously, it was shown that tumor necrosis factor alpha (TNF- ␣ ) production was associated ...
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Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy
... promote tumor control in numerous pre- clinical models, and is often associated with increased CTL effector capability ...~80% tumor rejec- tion of established mammary 4 T1 tumors in mice ...
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Tumor Necrosis Factor and Regulatory T Cells
... prehensively describe the relationship between tumor necrosis factor (TNF) and Treg cells, focusing on the effects of TNF on Treg cells and on TNF-producing Treg cells. Contradictory results have ...
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The 55 kD tumor necrosis factor receptor on human keratinocytes is regulated by tumor necrosis factor alpha and by ultraviolet B radiation
... This assumption is strongly supported by the observation that binding of UVB-induced endogenous TNFa to keratinocyte TNFR induced a biphasic modulation of 55-kD TNFR surface and mRNA exp[r] ...
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Tumor necrosis factor expression in human epithelial tumor cell lines
... Tumor necrosis factor (TNF) is a monokine with in vitro cytotoxicity for some but not all tumor ...epithelial tumor cell ...14 tumor cell lines has detectable levels of high ...
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Early gestational mesenchymal stem cell secretome attenuates experimental bronchopulmonary dysplasia in part via exosome-associated factor TSG-6
... of tumor necrosis factor- α -stimulated gene-6 (TSG-6) in human BPD tracheal aspirate and lung tissue of the BPD mouse model and its detection in EXO fraction (A) Relative TSG-6 expression in the ...
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Contribution of tumor necrosis factor alpha to the pathogenesis of stroke
... TNF-alpha stimulates release of three best- known beta chemokines — which can play a signif- icant role in inflammatory processes within the brain — i.e. macrophage inflammatory protein-1 alpha (MIP-1 alpha), macrophage ...
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Cachectin/Tumor Necrosis Factor
... Cachectinwas first isolated during a reseaich directed at the identification of basic mechanisms of cachexia in chronic disease. When rabbits are infected with tiypanosoma brucei, they lose upto 50% of their body weight. ...
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Tumor necrosis factor-alpha and Fas/Fas ligand signaling pathways in chronic spontaneous urticaria
... Tumor necrosis factor alpha (TNF-α) plays a central role in inflammatory processes, immune regulation and ...pathogenic factor in various diseases, including sepsis, cancers, as well as ...
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Tumor necrosis factor can induce fever in rats without activating protein breakdown in muscle or lipolysis in adipose tissue
... Tumor necrosis factor (TNF, cachectin) is a macrophage product that has been suggested to signal the loss of body weight, the decrease in adipose tissue and muscle mass, and anorexia during ...
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Targeting Mycobacterium tuberculosis Tumor Necrosis Factor Alpha Downregulating Genes for the Development of Antituberculous Vaccines
... TNF is arguably the best-established antimycobacterial immuno- logical factor in humans, as reflected by the enhanced susceptibil- ity to M. tuberculosis infection of individuals treated with TNF blockade therapy ...
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Activation of protein breakdown and prostaglandin E2 production in rat skeletal muscle in fever is signaled by a macrophage product distinct from interleukin 1 or other known monokines
... including tumor necrosis factor ("cachectin"), epidermal thymocyte-activating factor, eosinophil cytotoxicity-enhancing factor, interferon-alpha, beta, and gamma, ...
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