Tumor Necrosis Factor (TNF)
The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia
... Tumor necrosis factor (TNF) is a protein hormone implicated in the development of septic shock and other pathologic states. However, complexities inherent in detecting TNF synthesis by individual ...
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Cachectin/Tumor Necrosis Factor
... synthesized tumor necrosis factor, agonist peptide TNF (70-80) and demonstrated that it enhanced the human PMN-mediated killing of plasmodium falciparum in vitro and reduced the plasmodium chabaudi ...
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Comparative effectiveness and safety of rituximab versus subsequent anti–tumor necrosis factor therapy in patients with rheumatoid arthritis with prior exposure to anti–tumor necrosis factor therapies in the United States Corrona registry
... The first choice of biologic therapy is typically an anti- tumor necrosis factor(anti–TNF) agent [2]. While anti- TNF agents have been shown in large randomized con- trolled trials (RCTs) to be ...
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Effect of Tumor Necrosis Factor on Body Systems
... Tumor necrosis factor (TNF) is the prototypic member of a large cytokine family having two main types, tumor necrosis factor-alpha (TNF-α) and tumor necrosis ...
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Tumor necrosis factor can induce fever in rats without activating protein breakdown in muscle or lipolysis in adipose tissue
... Tumor necrosis factor (TNF, cachectin) is a macrophage product that has been suggested to signal the loss of body weight, the decrease in adipose tissue and muscle mass, and anorexia during ...
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Role of Eosinophils and Tumor Necrosis Factor Alpha in Interleukin 25 Mediated Protection from Amebic Colitis
... ABSTRACT The parasite Entamoeba histolytica is a cause of diarrhea in infants in low-income countries. Previously, it was shown that tumor necrosis factor alpha (TNF- ␣ ) production was associated ...
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Tumor Necrosis Factor and Regulatory T Cells
... prehensively describe the relationship between tumor necrosis factor (TNF) and Treg cells, focusing on the effects of TNF on Treg cells and on TNF-producing Treg cells. Contradictory results have ...
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Treatment with recombinant human tumor necrosis factor alpha protects rats against the lethality, hypotension, and hypothermia of gram negative sepsis
... Treatment with recombinant human tumor necrosis factor-alpha protects rats against the lethality, hypotension, and hypothermia of gram-negative sepsis.. Tumor necrosis factor TNF is a pe[r] ...
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Tumor necrosis factor expression in human epithelial tumor cell lines
... Tumor necrosis factor (TNF) is a monokine with in vitro cytotoxicity for some but not all tumor ...epithelial tumor cell ...14 tumor cell lines has detectable levels of high ...
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Contribution of tumor necrosis factor alpha to the pathogenesis of stroke
... TNF-alpha stimulates release of three best- known beta chemokines — which can play a signif- icant role in inflammatory processes within the brain — i.e. macrophage inflammatory protein-1 alpha (MIP-1 alpha), macrophage ...
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The tumor necrosis factor receptor and human neutrophil function Deactivation and cross deactivation of tumor necrosis factor induced neutrophil responses by receptor down regulation
... Despite numerous reports, the role of tumor necrosis factor (TNF) in polymorphonuclear leukocyte (PMN) function remains controversial. We found TNF to be a potent, pertussis toxin-independent ...
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Tumor necrosis factor-alpha and Fas/Fas ligand signaling pathways in chronic spontaneous urticaria
... Tumor necrosis factor alpha (TNF-α) plays a central role in inflammatory processes, immune regulation and ...pathogenic factor in various diseases, including sepsis, cancers, as well as ...
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TUMOR NECROSIS FACTOR ALPHA AND INTERLEUKIN 6 IN ESSENTIAL HYPERTENSION
... of tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) which might play an important role in the initiation and progression of hypertension by a variety of mechanisms such as giving rise to ...
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The role of tumor necrosis factor alpha in systemic lupus erythematosus
... (a) tumor necrosis factor (TNF) expression was low and TNF administration helpful or (b) TNF was high and TNF blockade of therapeutic benefit, depen- ding on the mouse model ...
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Cellular Responses to Tumor Necrosis Factor
... Tumor necrosis factor α (TNF) is a proinflammatory cytokine produced mainly by activated macrophages or monocytes and plays an important role in diverse cellular events, such as the production of ...
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No impact of tumor necrosis-factor antagonists on the joint manifestations of sarcoidosis
... To our knowledge, this is the only study to address specifically the efficacy and safety of TNF antagonists (infliximab, adalimumab, and etanercept) in the context of s[r] ...
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A role for tumor necrosis factor-α in ischemia and ischemic preconditioning
... growth factor) and vascular endothelial growth factor (VEGF) induced neuroprotection against glucose deprivation, NMDA excitotoxicity and oxygen glucose deprivation and that these effects required the ...
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Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet activating factor
... necrosis of the gastrointestinal tract. The morphological changes of TNF-induced bowel lesions are indistinguishable from those caused by PAF. The mechanism of TNF-induced bowel necrosis is unclear. In the ...
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Characterization in vitro of a human tumor necrosis factor binding protein A soluble form of a tumor necrosis factor receptor
... Results from biosynthetic labeling of cells with 35S-cysteine followed by immunoprecipitation with anti-TNF-BP indicated that TNF-BP is formed and released at the cell surface by cleavag[r] ...
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Targeting Mycobacterium tuberculosis Tumor Necrosis Factor Alpha Downregulating Genes for the Development of Antituberculous Vaccines
... TNF is arguably the best-established antimycobacterial immuno- logical factor in humans, as reflected by the enhanced susceptibil- ity to M. tuberculosis infection of individuals treated with TNF blockade therapy ...
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