Tumor necrosis factor (TNF-α)
Tumor necrosis factor-alpha and Fas/Fas ligand signaling pathways in chronic spontaneous urticaria
... Background: There is increasing evidence pointing to the important role of tumor necrosis factor‑alpha (TNF‑α), a key inflammatory and apoptotic mediator in urticarial inflammation. However, the role ...
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TUMOR NECROSIS FACTOR ALPHA AND INTERLEUKIN 6 IN ESSENTIAL HYPERTENSION
... of tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6) which might play an important role in the initiation and progression of hypertension by a variety of mechanisms such as giving rise to ...
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Effect of Tumor Necrosis Factor on Body Systems
... Tumor necrosis factor-alpha (TNF-α) is a cytokine involved in systemic inflammation and is a member of a group of cytokines that stimulate the acute phase ...
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Cachectin/Tumor Necrosis Factor
... synthesized tumor necrosis factor, agonist peptide TNF (70-80) and demonstrated that it enhanced the human PMN-mediated killing of plasmodium falciparum in vitro and reduced the plasmodium chabaudi ...
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Treatment with recombinant human tumor necrosis factor alpha protects rats against the lethality, hypotension, and hypothermia of gram negative sepsis
... Treatment with recombinant human tumor necrosis factor-alpha protects rats against the lethality, hypotension, and hypothermia of gram-negative sepsis.. Tumor necrosis factor TNF is a pe[r] ...
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Tumor necrosis factor can induce fever in rats without activating protein breakdown in muscle or lipolysis in adipose tissue
... Tumor necrosis factor (TNF, cachectin) is a macrophage product that has been suggested to signal the loss of body weight, the decrease in adipose tissue and muscle mass, and anorexia during ...
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Cellular Responses to Tumor Necrosis Factor
... Tumor necrosis factor α (TNF) is a proinflammatory cytokine produced mainly by activated macrophages or monocytes and plays an important role in diverse cellular events, such as the production of ...
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Comparative effectiveness and safety of rituximab versus subsequent anti–tumor necrosis factor therapy in patients with rheumatoid arthritis with prior exposure to anti–tumor necrosis factor therapies in the United States Corrona registry
... The first choice of biologic therapy is typically an anti- tumor necrosis factor(anti–TNF) agent [2]. While anti- TNF agents have been shown in large randomized con- trolled trials (RCTs) to be ...
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Tumor Necrosis Factor and Regulatory T Cells
... prehensively describe the relationship between tumor necrosis factor (TNF) and Treg cells, focusing on the effects of TNF on Treg cells and on TNF-producing Treg cells. Contradictory results have ...
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The tissue distribution of tumor necrosis factor biosynthesis during endotoxemia
... Tumor necrosis factor (TNF) is a protein hormone implicated in the development of septic shock and other pathologic states. However, complexities inherent in detecting TNF synthesis by individual ...
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Tumor necrosis factor expression in human epithelial tumor cell lines
... Tumor necrosis factor (TNF) is a monokine with in vitro cytotoxicity for some but not all tumor ...epithelial tumor cell ...14 tumor cell lines has detectable levels of high ...
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Role of Eosinophils and Tumor Necrosis Factor Alpha in Interleukin 25 Mediated Protection from Amebic Colitis
... E. histolytica disrupts the mucosal barrier in a sequential process of adherence to intestinal epithelial cells by a parasite Gal/GalNAc lectin, followed by killing of the epithelial cells in a nibbling process termed ...
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Contribution of tumor necrosis factor alpha to the pathogenesis of stroke
... TNF-alpha stimulates release of three best- known beta chemokines — which can play a signif- icant role in inflammatory processes within the brain — i.e. macrophage inflammatory protein-1 alpha (MIP-1 alpha), macrophage ...
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The tumor necrosis factor receptor and human neutrophil function Deactivation and cross deactivation of tumor necrosis factor induced neutrophil responses by receptor down regulation
... Despite numerous reports, the role of tumor necrosis factor (TNF) in polymorphonuclear leukocyte (PMN) function remains controversial. We found TNF to be a potent, pertussis toxin-independent ...
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The role of tumor necrosis factor alpha in systemic lupus erythematosus
... (a) tumor necrosis factor (TNF) expression was low and TNF administration helpful or (b) TNF was high and TNF blockade of therapeutic benefit, depen- ding on the mouse model ...
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Tumor necrosis factor alpha inhibits stem cell factor induced proliferation of human bone marrow progenitor cells in vitro Role of p55 and p75 tumor necrosis factor receptors
... interactions between TNF-alpha and SCF. Here, we demonstrate that TNF-alpha potently and directly inhibits SCF-stimulated proliferation of CD34+ hematopoietic progenitor cells. Furthermore, TNF-alpha blocked all colony ...
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Early gestational mesenchymal stem cell secretome attenuates experimental bronchopulmonary dysplasia in part via exosome-associated factor TSG-6
... : Tumor necrosis factor alpha; TSG-6: Tumor necrosis factor alpha-stimulated gene-6; TSG-6 siRNA: Tumor necrosis factor α stimulated gene-6 small interfering ...
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Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy
... T-cell–dependent tumor rejection (in 80% of treated mice) and a lasting memory ...scFv-expressing tumor vaccine with anti–4-1BB monoclonal antibody therapy synergized to induce regression of more ...
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Herb-partitioned moxibustion upregulated the expression of colonic epithelial tight junction-related proteins in Crohn’s disease model rats
... TNF-α: tumor necrosis factor-alpha; TNFR1: tumor necrosis factor receptor-1; ZO-1: zonula occludens proteins-1; UC: ulcerative colitis; ECCO: European Crohn’s and Colitis ...
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Targeting Mycobacterium tuberculosis Tumor Necrosis Factor Alpha Downregulating Genes for the Development of Antituberculous Vaccines
... TNF is arguably the best-established antimycobacterial immuno- logical factor in humans, as reflected by the enhanced susceptibil- ity to M. tuberculosis infection of individuals treated with TNF blockade therapy ...
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