tumor stroma
The fibrotic tumor stroma
... induces tumor-like vasculature within an engineered biomaterial ...both tumor stroma and tissue fibrosis), which reciprocally activates fibroblasts to become myofibroblasts (36, 37, ...in ...
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CELL SEPARATION AND GENE EXPRESSION ANALYSIS IN A TUMOR-STROMA INTERACTION MODEL
... as described previously (Dahse et al., 2002a). This special membrane (P.A.L.M. Microlaser Technologies AG, Germany) has been originally developed for the mounting of histological tissue sections on regular glass slides ...
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Scoring the tumor-stroma ratio in colon cancer: procedure and recommendations
... The tumor-stroma ratio (TSR) has been reported as a strong, independent prognostic parameter in colon cancer as well as in other epithelial cancer types, and may be implemented to routine pathology ...of ...
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TWIST1 and TWIST2 promoter methylation and protein expression in tumor stroma influence the epithelial-mesenchymal transition-like tumor budding phenotype in colorectal cancer
... the tumor budding ...with tumor budding in patient cohort 1 (n = ...of tumor epithelium and stroma from low- and high-grade budding cancers was ...TWIST2 stroma and no methylation, ...
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High levels of EGFR expression in tumor stroma are associated with aggressive clinical features in epithelial ovarian cancer
... in tumor stroma with clinicopathological features and with the expression level of Ki-67 were analyzed by SPSS ...in tumor stroma on the prognosis of patients with epithelial ovarian ...of ...
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Long-range and short-range tumor-stroma networks synergistically contribute to tumor-associated epilepsy
... in tumor environment, resulting in neuronal excitotoxicity and the occurrence of TAE [56, ...in tumor- bearing mice ...brain tumor cells and stromas in tumor microenvironment in the etiology ...
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A novel GFP nude rat model to investigate tumor-stroma interactions
... glioma stroma, but fluorescent transgenes have been ele- gantly used to elaborate the evolution of stroma during tumor ...that tumor-host interactions could be visualized by dual-color imaging ...
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FGF2 engineered SPIONs attenuate tumor stroma and potentiate the effect of chemotherapy in 3D heterospheroidal model of pancreatic tumor
... to tumor stroma, as benefits of using SPIONs are manifold, including large surface area and surface functionalization allowing easy conjugation of ligands/proteins on the surface, small size evading ...
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Original Article Clinical significance of EGFR expression in tumor stroma of NSCLC
... that tumor stroma played an important role in tumor proliferation and aggression, and fibro- blast was one of the most abundant components of tumor ...
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Tumor-stroma interactions differentially alter drug sensitivity based on the origin of stromal cells
... to tumor heterogeneity, most believe that effective treatments should be tailored to the features of an individual tumor or tumor ...identify tumor–stroma interactions that modulate ...
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Original Article Tumor-stroma ratio is an independent predictor for survival in NSCLC
... Abstract: Tumor-stroma ratio (TSR) has been identified as a new and practicable prognostic factor in some solid ...intratumor stroma were quantified as the stroma-rich group and those with ...
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Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention
... dsRed; tumor cells) were ...one tumor organoid is typically generated from a single cell (Supplementary Figure S1A), and several hundreds of organoids are formed per ...the tumor cells, LNCaP cells ...
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Lysyl hydroxylase 2 induces a collagen cross link switch in tumor stroma
... lung tumor cells influences collagen cross-linking in the tumor stroma through the upregula- tion of LH2 ...other tumor types and is a determi- nant of tumor cell ...promotes ...
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Activation of PI3K/Akt/mTOR signaling in the tumor stroma drives endocrine therapy-dependent breast tumor regression
... collagenous stroma) subtypes ...in tumor stroma as a predictor of outcome in breast cancer patients [34], finding that a higher ratio of tumor to stroma is associated with recurrence ...
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Correlation of Tumor-Stroma Ratio (TSR) With Primary Tumor Size and Lymph Node Involvement in Nasopharyngeal Carcinoma
... solid tumor, which low TSR (predomination of stromal component) correlates with unfavorable prognosis and increased risk of ...TSRwith tumor size and lymph node involvement ...of tumor stroma ...
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Association between tumor-stroma ratio and prognosis in solid tumor patients: a systematic review and meta-analysis
... Tumor-related stroma plays an active role in tumor invasion and ...The tumor–stroma ratio (TSR) in the pathologic specimen has drawn increasing attention from the field of predicting ...
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Targeting Enox1 in tumor stroma increases the efficacy of fractionated radiotherapy
... of tumor stroma would improve the ability of radiotherapy to cure ...targeting tumor vasculature might provide significant local tumor control, allowing a boost dose to be decreased in order ...
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Magnetic resonance-guided regional gene delivery strategy using a tumor stroma-permeable nanocarrier for pancreatic cancer
... the tumor stroma, CPPs were employed to decorate the nanocarrier (Gd-DPT) in this ...the tumor stroma was observed for Gd-DPT on real-time MR tracking (Figure 4) using an orthotopic nude mouse ...
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The evolving relationship of wound healing and tumor stroma
... limit tumor progression and improve response to ...the stroma, we expect that therapies will continue to be developed that modulate stroma in both wound healing and ...a tumor cannot grow ...
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Growing a tumor stroma: a role for granulin and the bone marrow
... The tumor stroma is critical in cancer progression; understanding its formation is therefore important biologically and ...indolent tumor in the same animal ...
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