tumor suppression
PML: Regulation and multifaceted function beyond tumor suppression
... possesses tumor suppressing activity by regulating apoptosis, cell cycle, senescence and DNA damage ...in tumor suppression has been extensively studied but increasing evidence indicates that PML ...
21
Two sides of the Myc-induced DNA damage response: from tumor suppression to tumor maintenance
... Yet, tumor suppres- sive responses were still completely dependent on ...dependent tumor suppression to a level sufficient to protect B-cells from Myc-induced lymphomagenesis, even in the absence of ...
10
Phosphorylcholine-based stealthy nanocapsules enabling tumor microenvironment-responsive doxorubicin release for tumor suppression
... the tumor model, nBSA-Dox efficiently accumulated in tumor and exhibited outstanding tumor ...improved tumor accumulation and tumor microenvironment- responsive drug release, has great ...
12
BRCA1, Hormone, and Tissue-Specific Tumor Suppression
... The notion that BRCA1 down-regulates the aromatase expression in ovarian granulosa cells is consistent with the clinical observation that prophy- lactic oophorectomy reduces the occurrence and re-occurrence of breast ...
8
Drosophila differentiation genes instrumental in tumor suppression
... Int J, Dc\" BioI 411 ]49 156 (1996) 149 Drosophila differentiation genes instrumental in tumor suppression ELISABETH GATEFF'*, URSULA KURZIK DUMKE', JASMINE WISMAR', THOMAS lOFFlER', NEGUSSE HABTEMICH[.] ...
8
Investigating E2F independent cell cycle control and tumor suppression by pRB
... The work presented in the thesis has enhanced our understanding of pRB-mediated cell cycle control and tumor-suppression. Using a variety of techniques, we have shown that the linear model of pRB repression ...
202
Tumor suppression by miR-31 in esophageal carcinoma is p21-dependent
... exerted tumor-suppressive effects in TE-7 ESCC cells, but not in TE-1 ESCC cells, although both of these cell lines harbor inactive ...the tumor suppressive actions of ...the tumor-suppressive effect ...
9
E2f8 mediates tumor suppression in postnatal liver development
... Mechanisms of E2F8-mediated tumor suppression. The observa- tion that either the complete loss of E2F8 expression or the spe- cific inactivation of E2F8’s DNA binding activity leads to HCC strongly suggests ...
16
miR 122 regulates hepatic lipid metabolism and tumor suppression
... metabolism, tumor suppression, and perhaps inflammation and ...the tumor-suppressive function of miR-122 illustrated by both groups suggests that the restoration of miR-122 expression may be of ...
5
Tumor suppression by p53 in the absence of Atm.
... dependent tumor suppression in a mouse brain tumor model driven by truncated SV40 T antigen is unaffected by Atm deficiency 31 ...the tumor suppressor function of ...these tumor models ...
28
Regulators of normal development and tumor suppression
... Int J D , Hiol 37 51 59 (1993) 5\ Regulators of normal development and tumor suppression LEO SACHS' Department of Molecular Genetics and Virology, Weizmann Institute of Science, Rehovot, Israel ABSTRA[.] ...
9
Myo9b is a key player in SLIT/ROBO mediated lung tumor suppression
... To understand the molecular mechanism underlying SLIT2 function in lung cancer cells, we examined the signal transduction pathways involved. Our previous study indicated that SLIT reduces active CDC42 levels in neurons ...
15
CD155 loss enhances tumor suppression via combined host and tumor intrinsic mechanisms
... melanoma tumor tissue (ME1004a) ...TMA tumor tissue samples from each core col- lected from different FFPE blocks were analyzed through two different panels: CD3/CD163/CD155/HMB45/DAPI and CD14/CD11c/CD155/ ...
14
Tumor suppression by small molecule inhibitors of translation initiation
... Here we report the anti-cancer efficacy, mode of action, pharmacokinetics, and toxicity profiles of 4EGI- 1 and #1181. Both agents inhibit translation initiation and preferentially abrogate expression of oncogenic ...
13
Cell Cycle Exit: Growth Arrest, Apoptosis, and Tumor Suppression Revisited
... group of basic helix-loop-helix (HLH) factors, which induce muscle differentiation and cause growth arrest long before induction of muscle proteins.. Careful analysis of the region invol[r] ...
9
p27KIP1 and PTEN cooperate in myeloproliferative neoplasm tumor suppression in mice
... a tumor suppressor gene located on chromosome 10q23 and is one of the most commonly mutated or deleted genes in human cancers, including acute lymphoblastic leukemia, juvenile myelomonocytic leukemia, and ...
6
Targeting autophagy in cancer management – strategies and developments
... Beclin-1 resulted in reduced autophagy in mice, indicating that Beclin-1 is a haplo-insufficient tumor suppressor gene, providing evidence that autophagy is a novel mechanism of cell growth control and ...
9
LITERATURE AND SCIENTIFICALLY CARVONE IS AN ANTICANCER AGENT
... Cytotoxic, tumor suppression, immunomodulatory, antiproliferative and inhibition of cancer cell migration, and chemopreventive effects have been observed in ...
7
The role of PML ubiquitination in human malignancies
... which tumor cells restrict the expression of tumor suppressors is important for the prognosis and intervention of ...multiple tumor suppressive functions, such as growth inhibition, apoptosis, ...
7
Ultrasound-mediated delivery of siESE complexed with microbubbles attenuates HER2+/- cell line proliferation and tumor growth in rodent models of breast cancer
... was used to deliver both short-hairpin RNA (shRNA) and small-interfering RNA (siRNA) to examine RNAi efficiency and cell proliferation after MB+US. Compared to siRNA, which may be delivered to and processed in the ...
11