Tumor suppressor,P53
New perspective on targeting the tumor suppressor p53 pathway in the tumor microenvironment to enhance the efficacy of immunotherapy
... the tumor suppressor p53 ( p53 or Trp53 ) ...the p53 pathway and are often associated with the stabilization and accumulation of mutant p53 ...increased p53 expression in ...
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Vesicular Stomatitis Virus Expressing Tumor Suppressor p53 Is a Highly Attenuated, Potent Oncolytic Agent
... The tumor suppressor p53 has been shown to exert potent antitumor properties, which may in part involve stimulating host innate immune responses to ...expressing p53 exhibited enhanced ...
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Effects of the Mortalin Inhibitor MKT-077 on the Tumor Suppressor p53 in Neuroblastoma IMR-32 Cells
... The tumor suppressor p53 is present in all human cells and prevents cancer formation by protecting the integrity of the ...bypass p53 through the over-expression of the mitochondrial matrix ...
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Transcriptional Inhibition of the Human Papilloma Virus Reactivates Tumor Suppressor p53 in Cervical Carcinoma Cells
... rapidly. Tumor suppressor p53 is responsible for early negative selection of damaged cells, which ensures exceptional stability of the human genome ...The p53 function is disturbed in the ...
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Human Immunodeficiency Virus Type 1 Nef Binds to Tumor Suppressor p53 and Protects Cells against p53-Mediated Apoptosis
... consensus p53 binding site oligonucleotide (lane 2), the labeled consensus p53 binding site oligonucleotide and an excess of the same unlabeled “cold” oligonucleotide (lane 3), the labeled consensus ...
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Tumor Suppressor p53 Stimulates the Expression of Epstein-Barr Virus Latent Membrane Protein 1
... for p53. Therefore, it is likely that p53 activates LMP1 expression indirectly through an ...both p53 and LMP1 under physiological and DNA-damaging conditions ...
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Role of tumor suppressor p53 and micro-RNA interplay in multiple myeloma pathogenesis
... Furthermore, p53 can also interact with DICER1 as evidenced by induced expression of p53 and premature senescence in DICER1 deficiency (incomplete miRNA maturation) [64], whereas mtp53 suppresses DICER1 by ...
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The regulation of cellular metabolism by tumor suppressor p53
... induces glutamine transporters SLC38A5 and SLC1A5 to promote glutamine uptake in cells. Furthermore, Myc induces the expression of glutaminase 1 (GLS1), an en- zyme that converts glutamine into glutamate as the first ...
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The tumor suppressor p53 connects ribosome biogenesis to cell cycle control: a double-edged sword
... of p53 in the literature correlates well with its mutation rates in ...cancer. P53 mutations occur at all stages of tumor development and all major forms of cancers benefit from p53 ...of ...
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Effect of hydroxyurea on the promoter occupancy profiles of tumor suppressor p53 and p73
... of p53 or p73 binding to a promoter ...bind p53 and p73 by qChIP, and found that the log2 OU correlated well with the MAP-deduced window scores (see Figure S2a in Additional file ...
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Direct α-synuclein promoter transactivation by the tumor suppressor p53
... ChIP assay was performed according to EZ- ChIP kit in- structions (Millipore). Briefly, 10 7 cells were fixed with formaldehyde (1 % final concentration), treated with gly- cine to quench unreacted formaldehyde and ...
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Control of the Tumor Suppressor p53 by Regulating MDM2 Activity and Stability
... If p53 were being modified with tagged-‐ ubiquitin, it would suggest a mechanism of auto-‐ubiquitin chain transfer onto the ...of p53 ubiquitination was even more dramatic (Figure ...
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LncRNA MT1JP functions as a tumor suppressor by interacting with TIAR to modulate the p53 pathway
... the tumor suppressor p53 through interaction with TIAR, a RNA-binding protein which has not previously been reported to associate with ...a p53 regulator, MT1JP modulates a series of cancer ...
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CP 31398 restores mutant p53 tumor suppressor function and inhibits UVB induced skin carcinogenesis in mice
... the tumor suppressor p53 are detectable in over 50% of all human ...Mutant p53 protein is incapable of transactivating its downstream target genes that are required for DNA repair and ...
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The Tumor Suppressor Protein P53 and the Antagonizing Oncoprotein E6 from Human Papillomavirus Type 16
... First, p53 response elements are varied across the genome due to different base-pair spacing between half sites and response elements which fulfill the consensus sequence requirement (El-Diery et al, ...
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The regulation of tumor suppressor protein, p53, and estrogen receptor (ERα) by resveratrol in breast cancer cells
... of p53 is mediated by p300 and CBP ...of p53 in a stress response is mainly due to acetylation. Human p53 becomes acetylated at Lys382 (Lys379 in mouse) in vivo to enhance p53-DNA ...acetylate ...
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SIRT1, Is It a Tumor Promoter or Tumor Suppressor?
... Then, can direct activation of SIRT1 both extend lifespan and reduce cancer risk? Several lines of evi- dence suggest that it is possible. First, it has been shown that activation of SIRT1 by a low dose of die- tary ...
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Investigation of solvent effect and NMR shielding tensors of p53 tumor-suppressor gene in drug design
... The p53 tumor-suppressor gene encodes a nuclear phosphoprotein with cancer- inhibiting ...this suppressor function through various mechanisms including gene deletions and point ...of ...
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Inhibition of p53 Tumor Suppressor by Viral Interferon Regulatory Factor
... of p53, including the growth suppression SH3B domain, the central core DNA binding domain, and the tetramerization ...alters p53 protein stability (39), vIRF does not appear to alter its ...targets ...
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RBM38 plays a tumor-suppressor role via stabilizing the p53-mdm2 loop function in hepatocellular carcinoma
... that tumor nod- ules originating from RBM38 over-expressed liver cancer cells had increased wtp53, decreased mdm2 and ki67 ex- pression compared to nodules originating from the cor- responding control ...
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