tumour microenvironment
The relationship between total and phosphorylated STAT1 and STAT3 tumour cell expression, components of tumour microenvironment and survival in patients with invasive ductal breast cancer
... both tumour cells and the tumour microenvironment including immune infiltrates such that STAT1 and STAT3 are thought to play opposite roles in tumorigenesis, regulating distinct gene signatures ...
15
Immunologic cellular characteristics of the tumour microenvironment of hepatocellular carcinoma drive patient outcomes
... the tumour vicinity consists mainly of ...immunologic tumour infiltration influence its malig- nant behaviour and could provide clinically informative prognostic biomarkers [21 – ...the tumour ...
8
Na+/H+ exchange in the tumour microenvironment: does NHE1 drive breast cancer carcinogenesis?
... association of 14-3-3 b with NHE1 at Ser703 in response to serum stimulation was demonstrated (Lehoux et al., 2001). 14-3-3 binding to Ser703 in its phosphorylated state was necessary for serum- induced exchanger ...
12
Adrenomedullin and tumour microenvironment
... a microenvironment that supports tumour growth and ...the tumour cells to grow and, eventually, to dissemin- ate ...the tumour cells themselves, although other types of cells such as mast ...
15
Consensus Analysis of Whole Transcriptome Profiles from Two Breast Cancer Patient Cohorts Reveals Long Non-Coding RNAs Associated with Intrinsic Subtype and the Tumour Microenvironment.
... of tumour purity as a source of inconsistency in signatures derived from different ...non- tumour cells in our patient samples provided the opportunity to discover several lncRNAs spe- cifically expressed ...
18
Modelling and analysis of the tumour microenvironment of colorectal cancer
... that tumour development proceeds in a manner simi- lar to Darwinian evolution, where a succession of genetic changes, each conferring a type of growth advantage, leads to a progressive conversion of normal cells ...
154
The relationship between members of the canonical NF-κB pathway, components of tumour microenvironment and survival in patients with invasive ductal breast cancer
... included tumour tissue samples from 376 breast cancer patients presenting with invasive ductal breast cancer between 1995 and 1998 in the West of Scotland (at Glasgow Royal Infirmary, Glasgow Western Infirmary and ...
12
Chemokines modulate the tumour microenvironment in pituitary neuroendocrine tumours
... The tumour microenvironment (TME) consists of neo- plastic, immune and stromal cells together with enzymes, growth factors and cytokines within the extracellular matrix [5–7, 11, ...and tumour ...
21
Molecular and cellular changes in the tumour microenvironment during IL-12 therapy
... the tumour microenvironment involve a variety of events exerted at different levels: the establishment of an anti-tumour immune response; direct toxicity against tumour cells and ...
171
Transformation of the tumour microenvironment by a CD40 agonist antibody correlates with improved responses to PD-L1 blockade in a mouse orthotopic pancreatic tumour model
... Despite the availability of recently developed chemotherapy regimens, survival times for pancreatic cancer patients remain poor. These patients also respond poorly to immune checkpoint blockade therapies (anti-CTLA-4, ...
13
Liposomal Nanoparticles Carrying anti-IL6R Antibody to the Tumour Microenvironment Inhibit Metastasis in Two Molecular Subtypes of Breast Cancer Mouse Models
... of tumour cells are acidic, the pH values of intracellular endosomes and lysosomes are even ...in tumour tissues and improve specific drug delivery as well as reduce the toxicity to normal ...
14
Targeting of BMI-1 with PTC-209 shows potent anti-myeloma activity and impairs the tumour microenvironment
... The polycomb complex protein BMI-1 (BMI-1) consti- tutes a pleiotropic factor with implications in the regula- tion of the cell cycle, DNA damage response, apoptosis, senescence as well as stem cell self-renewal and ...
13
Predictive value of improvement in the immune tumour microenvironment in patients with breast cancer treated with neoadjuvant chemotherapy
... This study was conducted at the Osaka City University Graduate School of Medicine, Osaka, Japan according to the Reporting Recommendations for Tumour Marker Prognostic Studies guidelines and following a retrospec- ...
10
The role of mesenchymal stem cells in the tumour microenvironment
... It is currently unclear what ratios of endogenous MSCs are present at the sites of developing tumours, or the maximal load of MSCs that can be therapeutically achieved within target tissues following transplantation. ...
224
Development of an in vitro cell-sheet cancer model for chemotherapeutic screening
... epithelial tumour microenvironment in vivo are lacking; therefore, we developed a new 3D epithelial cancer model using in vitro cell-sheet engineering to screen chemotherapeutic ...
10
Bifurcations and chaotic dynamics in a tumour immune virus system
... the tumour microenvironment (e.g., immune cells, tumour cells, on- colytic virus particles) can induce surprising bifurcations, including bifurcations to chaotic ...the tumour and virus growth ...
21
The role of spatial variations of abiotic factors in mediating intratumour phenotypic heterogeneity
... A novel perspective on cancer therapeutics can be obtained from the ac- cumulating evidence indicating that the progression of solid tumours is, in essence, an eco-evolutionary process (Merlo et al., 2006; Greaves and ...
28
Title: Oral Tumour Cell Migration and the Effect of the Local Soluble Factors from the Microenvironment on Signalling Pathways. Is It All about the Akt?
... promote tumour progression by activating migration and invasion ...the tumour microenvironment and ...the tumour cells causing a high risk of developing a second primary tumour in oral ...
24
Chemokine (C C motif) receptor 7 (CCR7) associates with the tumour immune microenvironment but not progression in invasive breast carcinoma
... between CCR7 and HER2 positivity, the molecular subtype analyses enabled by our large cohort did not find any significant associations with survival when performed within subgroups. However, CCR7 was associated with ...
10
The role of spatial variations of abiotic factors in mediating intratumour phenotypic heterogeneity
... the tumour microenvironment in mediating phenotypic selection of cancer ...multicellular tumour spheroid and on the 3D geometry of an in vivo human hepatic tumour, which was imaged using ...
25