tumour necrosis factor alpha
Nardilysin is involved in autoimmune arthritis via the regulation of tumour necrosis factor alpha secretion
... Anti-tumour necrosis factor alpha (TNF-α) biologic agents have led to a revolutionary improvement in the management of RA patients, indicating that this inflammatory cytokine plays a key role ...
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Clioquinol promotes cancer cell toxicity through tumour necrosis factor. alpha release from macrophages
... proteasome activity. However, these studies do not fully account for the ability of cell permeable metal ligands to inhibit cancer cell growth without affecting normal cells. In this study, we examined the effect of CQ ...
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Effects of Adalimumab, an Anti-tumour Necrosis Factor-Alpha (TNF-α) Antibody, on Obese Diabetic Rats
... DM is a serious and growing health concern worldwide, and it is associated with severe, acute and chronic complications that negatively influence both the quality of life and the survival of affected individuals. Recent ...
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Expression of matrix metalloproteinase-9 and tumour necrosis factor-alpha in the synovial cells of patients with meniscus tears
... risk factor for the de- velopment of post-traumatic arthritis and increases, by 50%, the probability of symptomatic osteoarthritis (OA) within 10–20 years of post-injury repair ...[22]. Tumour ...
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Tumour Necrosis Factor Alpha and Oxidative Stress in the Breath Condensate of Those with Non Small Cell Lung Cancer
... Keywords: Exhaled Breath Condensate; Lung Cancer; Ascorbic Acid Oxidation; Tumour Necrosis Factor Alpha 1. Introduction Lung cancer is a leading cause of cancer mortality worldwide, with over ...
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THE VEGF AND BMP-2 LEVELS IN PATIENTS WITH ANKYLOSING SPONDYLITIS AND THE RELATIONSHIP TO TREATMENT WITH TUMOUR NECROSIS FACTOR ALPHA INHIBITORS
... with tumour necrosis factor alpha (TNFα) inhibitors has proved to be an important step forward in the treatment of this disease, but for the time being it is not clear whether it favourably ...
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Anti tumour necrosis factor alpha therapy improves insulin sensitivity in normal weight but not in obese patients with rheumatoid arthritis
... risk factor for the development of cardiovascular disease, is common among patients with rheumatoid arthritis ...especially tumour necrosis factor alpha (TNFa), has been associated with ...
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Anti tumour necrosis factor alpha therapy improves insulin sensitivity in normal weight but not in obese patients with rheumatoid arthritis
... risk factor for the development of cardiovascular disease, is common among patients with rheumatoid arthritis ...especially tumour necrosis factor alpha (TNFa), has been associated with ...
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Anti-tumour necrosis factor alpha therapy improves insulin sensitivity in normal-weight but not in obese patients with rheumatoid arthritis.
... risk factor for the development of cardiovascular disease, is common among patients with rheumatoid arthritis ...especially tumour necrosis factor alpha (TNFa), has been associated with ...
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Tumour necrosis factor - alpha mediated mechanisms of cognitive dysfunction
... Aim: The aim of this review is to critically analyse neurobiological, immunological and molecular mechanisms through which TNF-α influences the development of cognitive dysfunction. Principal findings/results: The review ...
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The effect of oxygen tension on the cytotoxic action of tumour necrosis factor-alpha
... murine tumour cells and, although TNF-R levels were not investigated in this study, based on the literature it is likely that hypoxia also induces TNF-Rs in hypoxic SaF ...
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Tumour necrosis factor alpha gene polymorphisms and hospital outcomes in acute pancreatitis
... 2 Acute pancreatitis is a condition characterized by acute inflammation of the pancreas. In many instances the inflammation involves the peripancreatic soft tissue also. In majority of cases the inflammation is ...
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Melanoma cell migration is upregulated by tumour necrosis factor-alpha and suppressed by alpha-melanocyte-stimulating hormone
... In support of the above, we have recently shown that integrin expression, cell attachment and invasion through fibronectin are upregulated by the proinflammatory cytokine TNF- a and oppo[r] ...
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The effect of tumour necrosis factor-alpha and insulin on equine digital blood vessel function in vitro
... 8 10% newborn calf serum, 100 U/ml penicillin and 100 mg/ml streptomycin) and transferred to a 75cm 2 flask for incubation at 37 ° C in 5% CO 2 and 95% air. After 24 hours, erythrocyte contamination was removed with warm ...
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Association of tumour necrosis factor alpha and its receptors with thymidine phosphorylase expression in invasive breast carcinoma
... clonal antibodies for TNF-a, we found an abundance of this cytokine in malignant breast tissue, with immunoreactivity demonstrated by TAMs, malignant epithelial cells and vascular endoth[r] ...
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Clozapine-induced cardiotoxicity in rats: Involvement of tumour necrosis factor alpha, NF-κβ and caspase-3
... The increase in free radical formation and the atten- uation of antioxidant defences by clozapine, can lead to oxidative damage to cellular lipids, proteins and DNA [44]. This can explain the observed increase in both ...
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Systemic lupus erythematosus induced by anti tumour necrosis factor alpha therapy: a French national survey
... TNF alpha was tested in mice undergoing acute graft versus host disease using the parent- into-F1 model ...TNF alpha blocked the lymphocytopenic features characteristic of acute graft versus host disease ...
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Immunomodulatory parasites and toll-like receptor-mediated tumour necrosis factor alpha responsiveness in wild mammals
... Box plots show the individual scatter of data, the median (line), the interquartile range (box) and the range between the highest and lowest values (whiskers) excluding outliers (value[r] ...
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Chlamydia pneumoniae-induced tumour necrosis factor alpha responses are lower in children with asthma compared with non-asthma
... In contrast to the aforementioned studies, previous studies from our laboratory demonstrated that C. pneu- moniae-induced IFN-γ production was more prevalent in patients with asthma compared with non-asthmatic controls. ...
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Gene therapy with an improved doxycycline regulated plasmid encoding a tumour necrosis factor alpha inhibitor in experimental arthritis
... 38. Williams RO, Feldmann M, Maini RN: Antitumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc Natl Acad Sci USA 1992, 89:9784-9788. 39. Joosten LA, Helsen MM, van de ...
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