tumour necrosis factor-alpha
Tumour necrosis factor - alpha mediated mechanisms of cognitive dysfunction
... Mental and neurological disorders like schizophrenia and depression constitute 13% of the global disease burden, quickly surpassing the threat by cardiovascular disorders and cancer [1]. A common link between ...
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Chlamydia pneumoniae-induced tumour necrosis factor alpha responses are lower in children with asthma compared with non-asthma
... ► Using our Chlamydia pneumoniae model, can we determine whether innate cytokine responses (eg, tumour necrosis factor alpha (TNF-α)) that are protective of infection with intracell[r] ...
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Melanoma cell migration is upregulated by tumour necrosis factor-alpha and suppressed by alpha-melanocyte-stimulating hormone
... cytokine tumour necrosis factor a (TNF-a) can upregulate integrin expression, cell attachment and invasion of cells through fibronectin in a human melanoma cell line ...
8
Nardilysin is involved in autoimmune arthritis via the regulation of tumour necrosis factor alpha secretion
... arthritis in the K/Bxn sta model is attenuated in NrdcdelM mice To confirm the role of NRDC in autoimmune arthritis, we examined Nrdcflox/flox and NrdcdelM mice in another murine model, [r] ...
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The effect of oxygen tension on the cytotoxic action of tumour necrosis factor-alpha
... Although this is the first report showing that hypoxia can induce intracellular enTNF production in a murine tumour cell line a similar phenomenon has been noted in polymorphonuclear cells (PMNCs). Ghezzi et al. ...
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The effect of tumour necrosis factor-alpha and insulin on equine digital blood vessel function in vitro
... In other species, vascular and endothelial dysfunction can be caused by hyperinsulinaemia and/or insulin resistance (IR) [12] and inflammatory mediators [13]. Normally, insulin activates both the phosphatidylinositol ...
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Tumour Necrosis Factor Alpha and Oxidative Stress in the Breath Condensate of Those with Non Small Cell Lung Cancer
... Lung cancer biomarkers and those associated with tu- mour lysis may be able to aid in screening of lung cancer and possibly predict a patient’s response to cancer treat- ment [14]. TNF-α is highly expressed in tumours ...
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Multiplex cytokine analysis of dermal interstitial blister fluid defines local disease mechanisms in systemic sclerosis
... 0.03), tumour necrosis factor alpha (median: SSc ...stimulating factor (median: SSc ...growth factor, IL-10, IL-4, IL- 2 and IL-1a were all found to have a greater than ...
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Analysis of immunohistochemical expression of proinflammatory cytokines (IL-1α, IL-6, and TNF-α) in gallbladder mucosa: comparative study in acute and chronic calculous cholecystitis
... risk factor of gal- lbladder carcinoma [3, ...and tumour necrosis factor-alpha (TNF-a) are primarily secreted by monocytes and macropha- ges and represent potent multifunctional ...
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Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathies
... Detection of CD26 by Fluorescence-activated cell sorting (FACS) analysis. Expression of CD26 was detected by FACS analysis. (a) Expression level of CD26 on unstimulated fibroblasts. Background staining with secondary ...
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Biological treatment of ankylosing spondylitis: a nationwide study of treatment trajectories on a patient level in clinical practice
... Calendar trends for number of patients with ankylosing spondylitis AS starting a first ever tumour necrosis factor alpha inhibitor year 2006-2015, with age, disease duration, BASDAI and [r] ...
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TNFα inhibitors exacerbate Mycobacterium paratuberculosis infection in tissue culture: a rationale for poor response of patients with Crohn’s disease to current approved therapy
... background The role of Mycobacteriumavium subspecies paratuberculosis (MAP) in Crohn’s disease (CD) is increasingly accepted as evident by detection of the bacteria in the blood and intestinal tissue from patients with ...
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The antiviral role of cytokines
... The Enhancement of the in vivo Antiviral Efficacy of human Tumour Necrosis Factor alpha hTNF a by Antibodies in Vaccinia Virus Infection... There has been much interest recently on the p[r] ...
226
A model of inflammatory arthritis highlights a role for oncostatin M in pro inflammatory cytokine induced bone destruction via RANK/RANKL
... Oncostatin M is a pro-inflammatory cytokine previously shown to promote marked cartilage destruction both in vitro and in vivo when in combination with IL-1 or tumour necrosis factor alpha. ...
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Regulation of catabolic gene expression in normal and degenerate human intervertebral disc cells: implications for the pathogenesis of intervertebral disc degeneration
... decrease in tissue hydration, increase in fissure formation and loss of disc height. These catabolic processes are thought to be mediated by soluble factors such as the pro-inflammatory cytokines interleukin-1-beta ...
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Effect of Tumor Necrosis Factor on Body Systems
... Activation of the MAPK (Mitogen-Activated Protein Kinase) pathways: Of the three major MAPK cascades, TNF induces a strong activation of the stress-related JNK group, evokes moderate response of the p38-MAPK, and is ...
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Isolated limb perfusion with biochemotherapy and oncolytic virotherapy combines with radiotherapy and surgery to overcome treatment resistance in an animal model of extremity soft tissue sarcoma.
... The curative treatment protocol developed in our model was intensive, although it was well tolerated with no increase in wound complications or functional morbidity when com- pared with other cohorts. In clinical ...
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Polymorphism of tumor necrosis factor alpha (TNF-alpha) gene promoter, circulating TNF-alpha level, and cardiovascular risk factor for ischemic stroke
... risk factor for ischemic stroke in the Chinese Han ...risk factor for ischemic stroke and our meta-analysis data confirmed that patients with acute ischemic stroke compared to controls without stroke have ...
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Therapy of systemic lupus erythematosus: a look into the future
... the proinflammatory cytokines are significantly involved in tissue destruction. The central proinflammatory cytokines, tumor necrosis factor (TNF)- α and IL-1, are increased in SLE and can both be activated ...
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Apoptosis and the FLIP and NF-kappa B proteins as pharmacodynamic criteria for biosimilar TNF-alpha antagonists
... (nuclear factor kappa-light-chain- enhancer of activated B-cells), promotes the expression of anti-apoptotic genes, resulting in the production of the proteins TRAF1, TRAF2, cIAP-1, cIAP2 and ...
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