type 1/2 cannabinoid receptor
18F-MK-9470 PET imaging of the type 1 cannabinoid receptor in prostate carcinoma: a pilot study
... the type 1 cannabinoid (CB1R) and type 2 cannabinoid (CB2R) ...factor receptor (pEGFR) expression in PCa ...reducing cannabinoid metabol- ism and tumour ...
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Cannabinoid receptor type-2 stimulation, blockade, and deletion alter the vascular inflammatory responses to traumatic brain injury
... (Ki = 3.4 nM), in water-soluble emulsion Tocrisolve TM 100 (Tocris Catalog Number 1684) has appoximately 200- fold selectivity over CB1 receptors. The times for repeated intraperitoneal (ip) injections of 0-1966 (5 ...
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Relationships between glucose, energy intake and dietary composition in obese adults with type 2 diabetes receiving the cannabinoid 1 (CB1) receptor antagonist, rimonabant
... Relationship between glycaemia and dietary composition A strong correlation was observed between the reduc- tion in carbohydrate intake and improvement in gly- caemic control (as indicated by change in HbA1c ...
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The cannabinoid receptor type 1 is essential for mesenchymal stem cell survival and differentiation: implications for bone health
... CB 1 receptor during the osteogenic differentiation of MSCs har- vested from adult Wistar ...CB 1 receptor is increased during MSC osteogenic dif- ferentiation and is essential for the ...
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Upregulation of cannabinoid receptor type 2, but not TSPO, in senescence-accelerated neuroinflammation in mice: a positron emission tomography study
... The mice were placed in the prone position on a fixation plate and then set within the gantry hole of the PET scanner. After a 15-min transmission scan utilizing an external 68 Ge/ 68 Ga rod source (67 MBq) for ...
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Regulation of Adipose Tissue Metabolism by the Endocannabinoid System
... as type 2 diabetes and cardiovascular diseases is ...a cannabinoid 1 receptor (CB1R) inverse agonist, was one of the fi rst drugs that reached the European market to treat ...withdrawn ...
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Cannabinoid Receptor Type I Modulates Alcohol-Induced Liver Fibrosis
... Paraffin-embedded and frozen human liver tissues were obtained from consec- utive patients with ALD who underwent liver biopsy for diagnostic reasons. Pa- tients consumed at least 80 g/day of al- cohol, were ...
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Stimulation of cannabinoid receptor 2 (CB2) suppresses microglial activation
... CB 2 on the JAK/ STAT signaling pathway in primary cultured microglial ...CB 2 agonist ...heterodimer type II cytokine receptor, the JAKs are directly activated leading to STAT1 ...
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MicroRNA-139 modulates Alzheimer's-associated pathogenesis in SAMP8 mice by targeting cannabinoid receptor type 2.
... either 1 h or 1-4 day post-training, the SAMP8 + miR-139 group exhibited a much weaker preference for the novel object than the SAMP8 + miR-con group, while the SAMP8 + anti-miR-139 group exhibited a normal ...
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Expression of cannabinoid 1 and, 2 receptors and the effects of cannabinoid 1 and, 2 receptor agonists on detrusor overactivity associated with bladder outlet obstruction in rats
... and type of agonist for CB1 and CB2 receptors, however, these doses and types may not produce the maximal effect on the bladder of ...CB receptor expression in tissues de- pends on the availability of ...
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Activation of cannabinoid receptor type 2 attenuates surgery-induced cognitive impairment in mice through anti-inflammatory activity
... Interestingly, although postoperative JWH133 treat- ment significantly decreased TNF- α and MCP-1 expres- sion 1 day post surgery in the hippocampus, it failed to do so in the PFC. Similarly, the effects of ...
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Lower circulating endocannabinoid levels in children with autism spectrum disorder
... CB 1 R, CB 2 R : Cannabinoid receptor type-1, type-2; CBCL: Child Behavior Checklist; CGI-S : Clinical global impression- severity; DAGL: Diacylglycerol lipase; ...
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Combining rimonabant and fentanyl in a single entity: preparation and pharmacological results
... CB 1 and opioid receptors in the central nervous system structures involved in the control of nociception, motor activity, and brain ...the cannabinoid and opioid systems seems an interesting ...
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Synthesis of Amphibian Alkaloids and Synthesis and Affinity of Novel Cannabinoid Receptor Ligands
... methanol (MeOH) were purchased from Mallinckrodt Baker, Inc and were used under nitrogen without any further purification. Thin layer chromatography (TLC) 20 x 20 cm glass plates precoated with 250 µm silica gel were ...
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Increased placental expression of cannabinoid receptor 1 in preeclampsia: an observational study
... CB- receptor ligand anandamide (AEA) is synthesized on demand from the lipid precursor N-arachidonoyl phos- phatidylethanolamine (NAPE) by a specific phospholip- ase D enzyme (NAPE-PLD), and is primarily degraded ...
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Cannabinoid receptor 2 as a potential therapeutic target in rheumatoid arthritis
... The inhibitory effects of JWH133 on RA FLS and human osteoclasts prompted us to examine the compound for the inhibitory effects on murine CIA, an animal model of RA. Intraperitoneal administration of JWH133 (1 ...
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Microinjection of WIN55,212-2 as a Cannabinoid Agonist into the Basolateral Amygdala Induces Sensitization to Morphine in Rats
... In conclusion, it was shown that the CB1 cannabinoid receptor in BLA, are involved in sensitization to morphine in controlling pain pathways. Our study also confirmed the cross-talk between ...
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Identification of a bone morphogenetic protein type 2 receptor neutralizing antibody
... Objective: The bone morphogenetic protein (BMP) signaling pathway comprises the largest subdivision of the trans- forming growth factor (TGFβ) superfamily. BMP signaling plays essential roles in both embryonic ...
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HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity
... endogenous cannabinoid system to control their cal- cium currents ...Adrenergic receptor, dopamine D2 receptor [31], D1 receptor (unpublished ob- servation), mostly through the C terminal or ...
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Dual renin-angiotensin system inhibition for prevention of renal and cardiovascular events: do the latest trials challenge existing evidence?
... II receptor blocker and Angiotensin-Converting Enzyme inhibitor in nondiabetic renal Disease; CV: Cardiovascular; CVD: Cardiovascular Disease; DRI: Direct Renin Inhibitor; ELITE: Evaluation of Losartan In The ...
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