type-1 cannabinoid receptors
The motivation for exercise over palatable food is dictated by cannabinoid type-1 receptors
... CB 1 receptors displayed lower motivation for either wheel running or palatable feeding when proposed alone (see above), the balance between the respective drives for energy intake and energy expenditure ...
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Anti inflammatory effects of N acylethanolamines in rheumatoid arthritis synovial cells are mediated by TRPV1 and TRPA1 in a COX 2 dependent manner
... detect cannabinoid receptors and related ...collagen type II arthritis, mice were treated daily with the FAAH inhibitor JNJ1661010 (20 mg/kg) or ...
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18F-MK-9470 PET imaging of the type 1 cannabinoid receptor in prostate carcinoma: a pilot study
... 14. Burns HD, Van Laere K, Sanabria-Bohorquez S, Hamill TG, Bormans G, Eng WS, Gibson R, Ryan C, Connolly B, Patel S, Krause S, Vanko A, Van Hecken A, Dupont P, De Lepeleire I, Rothenberg P, Stoch SA, Cote J, Hagmann WK, ...
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The cannabinoid receptor type 1 is essential for mesenchymal stem cell survival and differentiation: implications for bone health
... the cannabinoid system enhances the survival, migration, and chondrogenic differentiation of MSCs, which are the three key points that determine the success of cell-based tissue-engineered repair strategies ...CB ...
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Jacob, Wolfgang (2007): Role of the Cannabinoid Receptor Type 1 (CB1) in Synaptic Plasticity, Memory and Emotionality. Dissertation, LMU München: Fakultät für Biologie
... In two single-cell recording studies, a high spatial and temporal precision of endocannabinoid action onto GABAergic interneurons could be demonstrated. As stated above, a brief stimulus train, that did not induce LTP ...
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Pharmacodynamics of cannabinoids
... various cannabinoid-type components called cannabinoids (presently estimated at about ...“cannabinoid receptors” [3]. Subsequently, discoveries of endogenous cannabinoid receptor ...
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Hybrid inhibitor of peripheral cannabinoid-1 receptors and inducible nitric oxide synthase mitigates liver fibrosis
... diluted 1:10 in corn oil) twice weekly and were concomitantly treated with vehicle, rimonabant (3 mg/ kg), or MRI-1867 (3 mg/kg) daily for 4 ...by 1-way ANOVA followed by Dunnett’s multiple comparisons ...
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Expression of cannabinoid 1 and, 2 receptors and the effects of cannabinoid 1 and, 2 receptor agonists on detrusor overactivity associated with bladder outlet obstruction in rats
... and type of agonist for CB1 and CB2 receptors, however, these doses and types may not produce the maximal effect on the bladder of ...these receptors in the urothelium and detrusor muscle and to ...
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Interleukin-6: an emerging regulator of pathological pain
... CB2Rs, cannabinoid CB2 receptors; CCI, chronic constriction injury; CFA, complete Freund ’ s adjuvant; CIPN, chemotherapy-induced peripheral neuropathy; DRG, dorsal root ganglia; EA, electroacupuncture; ...
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The effect of a dietary supplement (N-oleyl-phosphatidyl-ethanolamine and epigallocatechin gallate) on dietary compliance and body fat loss in adults who are overweight: A double-blind, randomized control trial
... central cannabinoid type 1 receptors (CB1) whose activation leads to an increase in appetite and, consequently, an intake of food ...tinal receptors, which signal the brain center to ...
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Endothelin-1 gene polymorphisms and diabetic kidney disease in patients with type 2 diabetes mellitus
... The clinical and laboratory comparisons between groups were performed by the unpaired Student’s test or the Chi square test as appropriate. Continuous variables were expressed as means and standard deviations (SD). ...
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nanoPaint: dynamic imaging of nanoscopic structural plasticity of the plasma membrane
... GFP-expressing receptors was obtained by tracing kymographs depicting the temporal movement of both QD nanoconstructs bound to CB1 receptors and GFP-tagged receptors (Figure 1b and Figure ...CB1 ...
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Adipose tissue endocannabinoid system gene expression: depot differences and effects of diet and exercise
... The findings that abdominal adipose tissue expresses higher levels of FAAH than gluteal adipose tissue, and caloric restriction and caloric restriction plus exercise differentially influenced local adipose tissue ...
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The synthetic cannabinoid WIN55,212-2 mesylate decreases the production of inflammatory mediators in rheumatoid arthritis synovial fibroblasts by activating CB2, TRPV1, TRPA1 and yet unidentified receptor targets
... ferent cellular target. Data from Bloom et. al demonstrate that WIN and other cannabinoids alter membrane polarization and many off-target effects of cannabinoids are only evident at concentrations that cause membrane ...
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Regulation of Adipose Tissue Metabolism by the Endocannabinoid System
... Evidence for a role of CB2R in WAT signaling is scarce, and is mostly linked to the regulation of in fl ammation. CB2R is expressed in WAT [67] and its expression is increased in obesity, especially within the ...
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Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
... thrombospondin 1 and thrombospondin 2, was not significantly affected by cannabinoid admin- istration (data not ...sels, cannabinoid-treated tumors displayed a pattern of blood vessels characterized ...
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Lower circulating endocannabinoid levels in children with autism spectrum disorder
... Circulating endocannabinoids are believed to come from multiple organs and tissues, including the brain, skeletal muscle, adipose tissue, liver, and kidney as well as circulating cells [42]. However, plasma endocannabi- ...
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Original Article Astrocytic expression of cannabinoid type 1 receptor in rat and human sclerotic hippocampi
... 1000S; Leica, Heidelberger, Nussloch, Ger- many) for CB1R immunohistochemical labeling. The sections were placed in PBS containing 25% sucrose and 10% glycerol for 1 hr for cryo- protection. After a freeze-thaw ...
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<p>Role of Cannabinoid Receptors in Crocin-Induced Hypoalgesia in Neuropathic Pain in Rats</p>
... Mechanical allodynia was assessed by Von Frey hairs through the method described by Ren. 32 Von Frey hairs (Stolting Co., the USA) are elastic fi laments which apply a different force to the surface depend on their ...
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Cannabinoid receptors contribute to astroglial Ca2+ signalling and control of synaptic plasticity in the neocortex
... Figure 1. Cannabinoid receptors activate astrocytic Ca 2þ -signalling and release of gliotransmitters. (a–c) Ca 2þ -signalling activated by the bath application of 500 nM of anandamide (AEA) to ...
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