Type 1 helper T cell
Follicular helper T cell signature in type 1 diabetes
... of T cell differentiation as a Th1/Th2 dichotomy, with Th1 cells responsible for tissue-specific autoimmunity, has led numerous researchers to hunt for a Th1 signature in T1D, with widely variable ...memory ...
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Iron oxide nanoparticles suppressed T helper 1 cell-mediated immunity in a murine model of delayed-type hypersensitivity
... Figure 1): (1) nonsensitized (but ovalbumin-challenged) group; (2) untreated ovalbumin-sensitized and challenged group; (3) vehicle-treated plus ovalbumin-sensitized and challenged group; and (4) iron oxide ...
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Identification of global regulators of T-helper cell lineage specification
... Transcriptional analysis of Th1- and Th2-specific genes Cellular differentiation to a specific subset requires activa- tion of cell type-specific genes and suppression of genes of alternative lineages. To ...
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Productive and lytic infection of human CD4+ type 1 helper T cells with macrophage-tropic human immunodeficiency virus type 1.
... CD4 1 T cells was not significantly affected by infection with either virus type during the observation ...CD4 1 T ...CD4 1 T cells infected with either macrophage- tropic ...
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T helper 17 cell cytokines and interferon type I: partners in crime in systemic lupus erythematosus?
... IFN type I signature is associated with an increase in Th17 cytokines expressed by memory CCR6 + T cells, we measured the percentages of IL-17A, IL-17F, IL-22 and IL-21 producing CCR6 + T memory ...
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Purified protein derivative of Mycobacterium tuberculosis and excretory secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production
... that T cells with stable Th1 or Th2 functional pattern exist not only in mice but also in humans and suggest that in the course of natural immunization certain infectious agents preferentially expand T ...
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In vitro Effects of Propranolol on T Helper Type 1 Cytokine Profile in Human
... Also, in our study propranolol significantly reduced IL-2 production in human leukemic T cells. As IL-2 has an imperative role in inflammation 19 the anti- inflammatory effect of propranolol reported by other ...
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Cell fate decision: T helper 1 and 2 subsets in immune responses
... [100]. T cells from mice deficient in the p38 upstream kinase MKK3 have an intrin- sic defect to produce normal levels of IFN- γ , even when provided with APCs from a wild-type B6 mouse ...
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T Helper 22 Pathway Evaluation in Type 1 Diabetes and Its Complications
... Fortynine patients with T1D and 43 healthy controls underwent the assessment of circulatory number of Th22 cells (by flow cytometry), serum level of Th22 related cytokines including Interleukin-22 (IL-22), Interleukin-10 ...
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Distinct gene expression profiles of human type 1 and type 2 T helper cells
... human T cells has been reported [1,31]. The expression profile of the type 2 cells has somewhat fewer inflammatory mediators than Th1 ...Th2 cell clones ...in type 1 cells ...Th1 ...
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Target Peptide Sequence within Infectious Human Immunodeficiency Virus Type 1 Does Not Ensure Envelope-Specific T-Helper Cell Reactivation: Influences of Cysteine Protease and Gamma Interferon-Induced Thiol Reductase Activities
... either HIV-1 NL4-3 or HIV-1 IIIB could be used interchangeably, yielding similar results (despite possible differences between the absolute envelope content in the two HIV-1-infected cell ...
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Multiple myeloma presenting as cutaneous leukocytoclastic vasculitis and eosinophilia disclosing a T helper type 1/T helper type 2 imbalance: a case report
... myeloma cell growth by the blockade of NF-κB and down-regulation of cytokines, such as IL-6 ...CD8 T cells, and repair T-helper sub- sets with the Th1/Th2 response ...
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Vaccine efficacy and T helper cell differentiation change with aging
... CD4 T cell ...antibody-dependent cell-mediated cytotoxicity [23]. Responding CD4 T cells differentiate into T follicular helper (Tfh) cells, which are required for germinal ...
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Immune contexture defined by single cell technology for prognosis prediction and immunotherapy guidance in cancer
... Th1: type 1 T helper; PD‑L1: programmed cell death ligand‑1; PD‑1: programmed cell death protein‑1; TIL: tumor infiltrating lymphocyte; TIM: ...
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Decoy receptors in the regulation of T Helper cell type 2 response
... IL-13R 1 was found to up-regulate the expression of IgM, IgG2a, and IgG2b from germinal center B cells may also suggest that this IL-13R subunit might act as an agonist ...B cell responses ...IL-13R ...
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Local Expression of T Cell Subsets in Sensitized and Unsensitized Experimental Cystic Echinococcosis.
... Th cell differentiation (Levy and Darnell, 2002; Zhu et ...Th1 cell differentiation (Uemura et ...regulatory T cells (Babu et al. 2005). In addition to cytotoxic T cell which is known ...
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Immune modulation of allergic airways disease
... Fowlpoxvirus vectors encoding the genes for murine IL-12 and the hemagglutinin (HA) glycoprotein of influenza virus (FPV-IL-12) and an appropriate control virus (FPV-HA-X) were available in this laboratory (JCSMR, ANU). ...
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Original Article Transformations of peripheral T cell subset distributions in oral cancer patients and the effect of P53 gene therapy in a short time
... blood T cells correlat- ed with the systemic invasiveness of therapy that patients underwent and was affected most clearly by surgery with adjuvant radiochemo- therapy ...
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Xenoepitope Substitution Avoids Deceptive Imprinting and Broadens the Immune Response to Foot-and-Mouth Disease Virus
... same 1 mg/ml stock solutions described above) following dilution to a concentration of 10 g/ml in ...diluted 1:1,000 in PTA-BSA and then added to plates after they were washed at a volume of 50 l/well and ...
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T-helper-1, T-helper-17, T-regulatory lymphocytes in hypertensive patients with diabetes mellitus type 2 or impaired glucose tolerance: association with clinical and metabolic parameters in a case control study
... Our results point out that important role in pathogenesis of inflammation during DM2 belongs to Th1-lymphocytes, as we observed elevation of IFN-γ + cells’ percentage in PMA + ionomycin stimulation and MFI of IFN-γ in ...
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