type 2A protein phosphatase
Mutations in the Saccharomyces cerevisiae Type 2A Protein Phosphatase Catalytic Subunit Reveal Roles in Cell Wall Integrity, Actin Cytoskeleton Organization and Mitosis
... PP2A and cell wall integrity: Since Ts- pph22 cells show an aberrant distribution of the actin cytoskeleton and defective bud morphogenesis at 37”, it is possible that PP2[r] ...
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Characterization of the interaction of polyomavirus middle T antigen with type 2A protein phosphatase.
... Furthermore, we detected protein kinase activity in PP2A immunoprecipitates and protein phosphatase activity in src immune complexes from extracts of middle T-antigen-transformed, but no[r] ...
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Protein phosphatase 2A regulates self renewal of Drosophila neural stem cells
... significant number of cells in tws 60 larval brains are labeled by activated Caspase 3 (also known as Decay), in contrast with wild- type brains in which very few cells are labeled (see Fig. S1F in the ...
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Induction of p53-Independent Apoptosis by the Adenovirus E4orf4 Protein Requires Binding to the Bα Subunit of Protein Phosphatase 2A
... binding protein (HA-MBP) present at the amino ...code. Protein expression. To verify protein expression from wild-type and mutant E4orf4 plasmids, Lipofectamine PLUS (Gibco-BRL) was used ...
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Role of B Regulatory Subunits of Protein Phosphatase Type 2A in Myosin II Assembly Control in Dictyostelium discoideum
... Although there have been extensive studies in the Dictyoste- lium system, both defining the biochemistry of MHC kinases and validating the in vivo importance of the MHC kinases MHCK A, B, and C (13, 20, 23), to date ...
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Genetic Analysis of B55α/Cdc55 Protein Phosphatase 2A Subunits: Association with the Adenovirus E4orf4 Protein
... Figure 2A (plates at the left) shows that al- though cdc55 mutant yeast reconstituted with wild-type CDC55 lost viability following the expression of E4orf4, all of the mu- tants were resistant to E4orf4 ...
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Amino-terminal regions of polyomavirus middle T antigen are required for interactions with protein phosphatase 2A.
... MT protein expressed in parallel transfections (see ...associated phosphatase activity were also defective for associated kinase activity ...mutant protein behaved simi- larly to wild-type MT ...
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Protein phosphatase 2A (PP2A): a key phosphatase in the progression of chronic obstructive pulmonary disease (COPD) to lung cancer
... cell type is often due to a com- bination of intrinsic factors; such as genetic alteration, and extrinsic factors; such as environmental exposure ...of protein phosphatase 2A (PP2A) in the ...
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Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila
... Protein phosphatase type 2A complex (PP2A) has been known as a tumor suppressor for over two decades, but it remains unclear exactly how it suppresses tumor ...E protein levels, ...
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Adenovirus Protein E4orf4 Induces Premature APCCdc20 Activation in Saccharomyces cerevisiae by a Protein Phosphatase 2A-Dependent Mechanism
... of Pds1 and Scc1, studies of HU similar to those described in the legend for Fig. 5 to 7 were performed using two types of E4orf4 mutants. The class I E4orf4 mutant R81AF84A fails to bind B55/Cdc55 and is not toxic in ...
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Genetic variation in the tau protein phosphatase 2A pathway is not associated with Alzheimer's disease risk
... which jointly consider multiple variants in interacting or related genes, might complement the most-signifi- cant SNPs/genes approach for interpreting genome- wide association (GWA) data on complex diseases [7,8]. In ...
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TORC2 Signaling Is Antagonized by Protein Phosphatase 2A and the Far Complex in Saccharomyces cerevisiae
... Similar phenotypes of far11D and sac7D mutations promp- ted us to determine whether they act through the same mo- lecular mechanism. Accordingly, we compared the growth of a tor2-21 sac7D far11D triple mutant to ...
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Protein phosphatase 2A modulates podocyte maturation and glomerular functional integrity in mice
... revealed that proteinuria results from defects in the actin cytoskeleton, the slit diaphragm, the glomerular base- ment membrane, and podocyte loss. Interestingly in present study, deletion of PP2A in podocytes leads to ...
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Role of GSK3β and PP2A on Regulation of Tau Phosphorylation in Hippocampus and Memory Impairment in ICV STZ Animal Model of Alzheimer’s Disease
... Intracerebroventricular administration (ICV) of streptozotocin (STZ) in rats has been associated to desensitization of the insulin receptor (IR) and biochemical changes similar to those occurring in Alzheimer’s disease ...
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Therapeutic relevance of the protein phosphatase 2A in cancer
... Upon PP2A inhibition with cantharidin treatment, we found preferential loss in viability of the PLK1- overexpressing cells but not the control cells (Figure 2B). To corroborate the specificity of these results, a less ...
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FAM122A, a new endogenous inhibitor of protein phosphatase 2A
... the protein level, protein phosphorylation is dynamically controlled by kinases and phosphatases, whose opposite actions reversibly phosphorylate proteins ...[1]. Type 2A protein ...
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Catalytic Subunit 1 of Protein Phosphatase 2A Is a Subunit of the STRIPAK Complex and Governs Fungal Sexual Development
... striatin-interacting phosphatase and kinase (STRIPAK) complex, which has been described in organisms ranging from yeasts to ...heterotrimeric protein phosphatase PP2A is a subunit of ...
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Protein Phosphatase 2A Enhances Activation of Human Immunodeficiency Virus Type 1 by Phorbol Myristate Acetate
... type 2 (HIV-2) is activated in monocytic cells by PP2A (14). Several recent reports have suggested that PP2A activity may be altered in differentiating monocytes. Differentiation of HL-60 cells into granulocytes ...
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Restricted Protein Phosphatase 2A Targeting by Merkel Cell Polyomavirus Small T Antigen
... sT protein stability and limited our ability to assess interactions and functional activities for these mu- tants (Table ...No protein was detected for the H130A substitu- tion ...
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The Phosphatase Subunit Tap42 Functions Independently of Target of Rapamycin to Regulate Cell Division and Survival in Drosophila
... As cells with a growth disadvantage can be eliminated suppression of autophagy, are not affected by loss of through a process of cell competition (Morata and Tap42. While it remains possible that additional effects ...
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