Type 2 and 3 secretion systems
Structural organisation of the type IV secretion systems
... complete our understanding of the IM channel by deter- mining the structure of VirB6 and VirB8 bound to the CC. Ultimately, the structure of the entire translocation machine will need to be determined. A related question ...
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2 and 3 substituted imidazo [1,2 a] pyrazines as inhibitors of bacterial type IV secretion
... the type IV secretion system to translocate the toxic protein CagA into gastric epithelial cells, and in doing so induces a number of changes in the host ...7 Type IV secretion systems ...
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Biological Diversity and Evolution of Type IV Secretion Systems
... Collectively, the T4SSs can translocate DNA and monomeric and multimeric protein substrates to a variety of bacterial and eukaryotic cell types. Detailed phylogenomics analyses have established that the T4SSs evolved ...
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Type IV secretion systems: versatility and diversity in function
... Institute of Structural and Molecular Biology, UCL and Birkbeck, Malet Street, London WC1E 7HX, UK. cmi_14991203..1212 Summary Type IV secretion systems (T4SSs) are large protein complexes which ...
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The Specificity of Secretion through the Alpha and Beta Type II Secretion Systems of Escherichia coli
... 28 it requires amplification with PCR primers encoding the DNA sequences of the DNA flanking the targeted integration site fused to standard PCR primers to amplify the DNA to be inserted (Figure 8). The lambda RED ...
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The type III protein secretion systems (T3SS) of Gram-negative
... distinct type III secretion systems (T3SS) that produce needle-like injectisomes or pili for the delivery of effector proteins into host ...(Pantoea secretion island 2 [PSI-2]) ...
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The type IV secretion and the type IV pili Systems of Neisseria gonorrhoeae Jain, Samta
... into the chromosome. In Neisseria gonorrhoeae, the genetic island is called the Gonococcal Genetic Island (GGI). The DNA of the GGI contains the information to create 60 proteins, 18 of these proteins seem to function in ...
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Recent advances in the structural and molecular biology of type IV secretion systems
... T4SS 3–10 structure represents a significant breakthrough in the field of secretion, there are still a considerable number of questions in need of ...is secretion being regulated by its various ...
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Escherichia coli type III secretion system 2: a new kind of T3SS?
... 14. Silva-Herzog E, Detweiler CS: Salmonella enterica replication in hemophagocytic macrophages requires two type three secretion systems. Infect Immun 2010, 78:3369 – 3377. 15. Hayashi T, Makino K, ...
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Understanding the sequential activation of Type III and Type VI Secretion Systems in Salmonella typhimurium using Boolean modeling
... The current study presents a comprehensive model representing cross-talk among the regulatory elements of the three major pathogenicity islands in S. typhimurum and predicts probable additional regulatory links to impute ...
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Targeting of Flavobacterium Johnsoniae Proteins for Secretion By the Type IX Secretion System
... protein secretion systems to deliver proteins across the outer ...Protein secretion systems enable the bacteria to survive in various ecological niches and provide obvious competitive ...
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Structure of HrcQ(B)-C, a conserved component of the bacterial type III secretion systems
... addition, type III secretion systems are also required for biogenesis of the bacterial ...the secretion apparatus of Pseudomonas syringae with homologues in all type III systems, ...
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Structure of a translocation signal domain mediating conjugative transfer by Type IV secretion systems
... 3 University of Graz, Institute of Chemistry, Heinrichstrasse 28, 8010 Graz, Austria. Summary Relaxases are proteins responsible for the transfer of plasmid and chromosomal DNA from one bacterium to another during ...
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Making connections: snapshots of chlamydial type III secretion systems in contact with host membranes
... Subsequent single particle analysis of core complexes isolated from the membranes of diverse Gram-negative bacterial pathogens has revealed a conserved structure comprising oligomeric rings embedded in the inner and ...
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Q&A: insulin secretion and type 2 diabetes: why do β-cells fail?
... Insulin’ s other function - its ability to enhance growth - is mirrored by several hormones, such as insulin-like growth factor 1 and 2. It is only the role of insulin in glu- cose homeostasis that is unique. We ...
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Investigating the relationship between quorum sensing, motility, and the type 3 secretion system of Yersinia pseudotuberculosis
... while 3-oxo-C12-HSL can activate a gfp reporter in the lungs of mice infected with ...QS systems (Wu et ...and secretion systems of the type 1 (Liu et al., 2008), type 2 ...
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Engineering the flagellar type III secretion system: improving capacity for secretion of recombinant protein.
... ing secretion of a range of therapeutic recombinant pro- ...the secretion titres reported in other E. coli secretion systems, by achieving extracellular secreted titres in the high mg L −1 ...
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Migration of Type III Secretion System Transcriptional Regulators Links Gene Expression to Secretion
... on type III secretion systems (T3SSs) of the Hrc-Hrp 1 family to subvert their plant ...while secretion is controlled by the gatekeeper ...and secretion cascades through the direct ...
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Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems
... VirB8/TrwG heterodimers, determined via bacterial two-hybrid assays and molecular modeling, indicate that differential ex- pression of trw and vir systems is the likely barrier to VirB8-TrwG interchangeability. We ...
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Role of the type VI secretion systems during disease interactions of Erwinia amylovora with its plant host
... The lambda red recombination system [38] was used to replace consecutive genes EAMY_3020–3021 and EAMY_3227–3228 (coding for TssB1/TssC1 and TssB2/ TssC2) in both T6SS clusters. The resulting single mu- tants were named ...
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