type I collagen alpha-1
Dietary intervention, but not losartan, completely reverses non-alcoholic steatohepatitis in obese and insulin resistant mice
... Col1a1: Collagen type I alpha 1; CPT1A: Carnitine palmitoyltransferase 1A; FAS: Fatty acid synthase; FAT/CD36: Fatty acid translocase/cluster of differentiation 36; FATP5: Fatty acid ...
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Rescue of type I collagen-deficient phenotype by retroviral-vector-mediated transfer of human pro alpha 1(I) collagen gene into Mov-13 cells.
... The proalI collagen cDNA is functional because infection of Mov-13 cells with the vector rescued the mouse proa2I chain and restored type I collagen expression.. Our experiments demonstr[r] ...
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Mithramycin selectively inhibits collagen alpha 1(I) gene expression in human fibroblast
... the collagen-alpha 1(I) and -alpha 2(I) genes form the triple helical molecule collagen type I, which constitutes the major ECM protein in tissue ...The ...
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STUDY OF RELATIONSHIP BETWEEN SP1 POLYMORPHISM IN THE COLLAGEN TYPE I ALPHA -1 (COLIA1) GENE AND OSTEOPROSIS IN PATIENTS WITH BETA-THALASSEMIA.
... that collagen gene one alpha one genotype diagnosebone fracture by techniquesthat are partly nondependent of bone mineral density and revealed high risk of osteopenic fracture in relation to SP1 ...
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Prostaglandin E2 induces Skin Aging via E-prostanoid 1 in Normal Human Dermal Fibroblasts
... Abstract: Collagen type I production decreases with aging, leading to wrinkles and impaired skin ...inhibits collagen production and induces matrix metallopeptidase 1 (MMP1) expression ...
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Osteogenesis imperfecta The position of substitution for glycine by cysteine in the triple helical domain of the pro alpha 1(I) chains of type I collagen determines the clinical phenotype
... normal type I collagen molecules and additional molecules that had one or two alpha 1(I) chains that contained a cysteine residue within the triple-helical domain, a region from ...
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Osteogenesis imperfecta type IV Biochemical confirmation of genetic linkage to the pro alpha 2(I) gene of type I collagen
... (OI) type IV is genetically linked to the pro alpha 2(I) gene of type I collagen synthesize two populations of pro alpha 2(I) ...pro alpha 2(I) causes ...
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Frameshift mutation near the 3' end of the COL1A1 gene of type I collagen predicts an elongated Pro alpha 1(I) chain and results in osteogenesis imperfecta type I
... members have one normal COL1A1 allele and another from which the intragenic Eco RI restriction site near the 3' end of the gene is missing. Amplification by polymerase chain reaction and sequence determination of the ...
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<p>Upregulation Of Protein Tyrosine Phosphatase Receptor Type C Associates To The Combination Of Hashimoto’s Thyroiditis And Papillary Thyroid Carcinoma And Is Predictive Of A Poor Prognosis</p>
... COL1A1, Collagen type I alpha 1 chain; DEGs, Differentially expressed genes; FC, Fold change; FDR, False positive rate; GAPDH, Glyceraldehyde- 3-phosphate dehydrogenase; GO, Gene ...
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Amino Acids Sequences Analysis on Collagen
... on collagen type I chains, the aims of the study were to identify the principal property component and to analyze the similarities within and between collagens on five ...on collagen ...
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Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reaction
... five collagen genes (type I collagen, alpha 2 chain [COL1A2], type II collagen alpha 1 chain [COL2A1], type III collagen alpha 1 ...
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Analysis of normal and osteoarthritic canine cartilage mRNA expression by quantitative polymerase chain reaction
... five collagen genes (type I collagen, alpha 2 chain [COL1A2], type II collagen alpha 1 chain [COL2A1], type III collagen alpha 1 ...
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Diminished type I collagen synthesis and reduced alpha 1(I) collagen messenger RNA in cultured fibroblasts from patients with dominantly inherited (type I) osteogenesis imperfecta
... Type I osteogenesis imperfecta (OI) is characterized clinically by a moderate fracture frequency with minimal bone deformity and dominant ...of type I ...of type I ...elevated ...
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Sintered dicalcium pyrophosphate treatment attenuates estrogen deficiency-associated disc degeneration in ovariectomized rats
... retrieval and the blocking of endogenous peroxidase. The resulting slides were incubated overnight at 4 ° C with anti-rat MMP-1, MMP-3, MMP-13, type II collagen, aggre- can, and VEGF (1:100; ...
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Collagen and Collagen derived Fragments Are Chemotactic for Tumor Cells
... in collagen such as liver, lungs, and bone are frequently sites of tumor cell ...to collagen in ...the collagen helix caused similar ...that collagen or collagen fragments released ...
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New diagnostic modalities and emerging treatments for neonatal bone disease
... As yet, no intervention has emerged that alters the material quality of bone; one potential approach to this issue would be the removal of mutant protein prior to its export from the cell, a process called autophagy. ...
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d alpha tocopherol inhibits collagen alpha 1(I) gene expression in cultured human fibroblasts Modulation of constitutive collagen gene expression by lipid peroxidation
... stimulates collagen gene transcription in cultured fibroblasts, and this effect is mediated through the induction of lipid peroxidation by ascorbic ...of collagen production, but the mechanisms of ...
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Abnormal alpha 2 chain in type I collagen from a patient with a form of osteogenesis imperfecta
... pro alpha-chain, the alpha-chain, and of the mammalian collagenase cleavage products of the pro alpha- and alpha-chains indicates that the abnormality is confined to the alpha ...
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Type-1 pericytes accumulate after tissue injury and produce collagen in an organ-dependent manner
... A 1 cm incision was made perpendicular to the sternum at the sixth intercostal ...approximately 1 to 2 mm below the edge of the left atrium along a line extending from the junction of the ascending aorta ...
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Effect of Phase I Therapy on Salivary Carboxyterminal Telopetide of Type I Collagen in Chronic Periodontitis Patients
... 26 Subjects were selected randomly, with no discrimination in age and sex between both the groups. Study protocol was explained and written informed consent (Annexure 2, 3) was obtained from all subjects. Thorough ...
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