type I IFN
Virus induced type I IFN stimulates generation of immunoproteasomes at the site of infection
... a type I IFN–dependent ...nous type I IFN to induce ...RNA–induced IFN generates immuno- proteasomes in hepatoma ...gene I (RIG-I) results in the ...
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Cell type-specific function of TRAF2 and TRAF3 in regulating type I IFN induction
... Type I interferon (IFN) plays a crucial role in innate immunity against viral infections [1, ...of type I IFNs is typically mediated by pattern-recognition receptors (PRRs), including ...
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Proteolysis of MDA5 and IPS 1 is not required for inhibition of the type I IFN response by poliovirus
... increases IFN- β mRNA levels and im- proves survival in a mouse model of EV71 pathogenesis ...impede type I IFN synthesis ...the Type I IFN response initiated by both RLR ...
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Type I IFN signaling in CD8– DCs impairs Th1 dependent malaria immunity
... Type I IFNs are crucial for protection against viruses but can facil- itate survival of many pathogens, such as Listeria (1, 2), Mycobac- teria (3–7), Staphylococci (8), and Lymphocytic choriomen ingitis ...
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The type I IFN induction pathway constrains Th17 mediated autoimmune inflammation in mice
... though type I IFN–mediated IL-27 production plays a criti- cal role in limiting Th17 development and autoimmune response, this finding does not exclude the possibility that other cytokines, such as ...
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TRAM is required for TLR2 endosomal signaling to type I IFN induction
... not type I IFN responses, after ligand engagement (7, ...induce type I IFN responses, while live virus-induced type I IFN has been shown to be at least ...
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Type I IFN system activation in newborns exposed to Ro/SSA and La/SSB autoantibodies in utero
... produce type I IFN on exposure to Ro/SSA and La/SSB autoantibodies combined with apoptotic/necrotic mate- rial, but whether fetal cells are equally capable of such a response is not ...an IFN ...
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Type I IFN innate immune response to adenovirus mediated IFN γ gene transfer contributes to the regression of cutaneous lymphomas
... Type I IFN resistance in ...in type I/II IFN signaling (including altered ISG expression), a phenomenon termed IFN resistance ...in type I/II IFN ...
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Influence of type I IFN signaling on anti-MOG antibody-mediated demyelination
... for type I IFN signaling for NMO-like pathology, showing that it was reduced in mice lacking the receptor for type I IFN ...recombinant IFN-β is not an effective therapy ...
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Toll like receptor 9–induced type I IFN protects mice from experimental colitis
... whether IFN-α/β directly prevents the damage inflicted by DSS in the colon, we injected recombinant mouse IFN-β (mIFN-β) ...by type I ...
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Double-Stranded RNA Induces Biphasic STAT1 Phosphorylation by both Type I Interferon (IFN)-Dependent and Type I IFN-Independent Pathways
... that type I IFNs are produced during viral infection. In addition, type I IFN is known to activate ...the type I IFN ...of type I IFN ...
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Wild type measles virus attenuation independent of type I IFN
... wild type isolate propagated on PBMCs with G954-V13, a virus adapted from G954-PBL by 13 passages on Vero ...of type I IFN correlate with an attenuated phenotype, this study shows the ...
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Hemagglutinin of Influenza A Virus Antagonizes Type I Interferon (IFN) Responses by Inducing Degradation of Type I IFN Receptor 1
... circumvent type I interferon (IFN) responses, particularly by inhibiting the synthesis of type I ...the type I IFN receptor (IFNAR)-mediated signaling ...the ...
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β-catenin promotes the type I IFN synthesis and the IFN-dependent signaling response but is suppressed by influenza A virus-induced RIG-I/NF-κB signaling
... of IFN-β expression upon IAV ...CBP/p300, IFN-β transcription ...the IFN-β activation pathway provoked by viral RNA, this was fur- ther affirmed via comparison of the dimerization cap- acity of IRF3 ...
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Type I IFN blockade uncouples immunotherapy induced antitumor immunity and autoimmune toxicity
... of IFN-α/-β signaling, either by functional blockade or rational selection of an OVV backbone, ameliorated autoimmune side effects without compromising antitumor ...for IFN-α/-β in facilitating autoimmune ...
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Blockade of Type I Interferon (IFN) Production by Retroviral Replicating Vectors and Reduced Tumor Cell Responses to IFN Likely Contribute To Tumor Selectivity
... in IFN-␣/ production due to deletions and rearrange- ment in the IFN gene cluster located at chromosome 9p21-22 (12, ...and type I IFN signaling pathways and to delineate the mechanism ...
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TRIM13 Is a Negative Regulator of MDA5-Mediated Type I Interferon Production
... ulate type I IFN production in innate immune cells by activating (7, 30) or inhibiting (31, 32) RIG-I ...under type I IFN-stimulating conditions ...modulates type ...
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Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB
... counteract IFN induction and IFN-stimulated antiviral ...of IFN-  through a failure of nuclear translocation of IRF3 and NF- B ...lineage I WNV variant, identified NS2A as an inhibitor of ...
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PKR and RNase L Contribute to Protection against Lethal West Nile Virus Infection by Controlling Early Viral Spread in the Periphery and Replication in Neurons
... Though studies to date have not directly tested the role of PKR and RNase L in modulating flavivirus infection in vivo, components of the RNase L signaling pathway have been im- plicated in the control of WNV infection. ...
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Interplay of Acute and Persistent Infections Caused by Venezuelan Equine Encephalitis Virus Encoding Mutated Capsid Protein
... in type I interferon (IFN) signaling, the capsid mutants demonstrated very efficient persistent ...in IFN production or signaling, the same mutants were capable of inducing a long-term ...
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