Type I IFN-induction pathway
The type I IFN induction pathway constrains Th17 mediated autoimmune inflammation in mice
... the type I IFN induction pathway in macrophages plays an important role in modulating Th17 ...TRIF pathway may function as a brake to reduce the inflammatory response induced by ...
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TRAM is required for TLR2 endosomal signaling to type I IFN induction
... impaired induction of type I IFN, indicating a role for TRAM in this TLR2-dependent pathway, while Staphylococcus aureus stimulated IFN-β was also ...causing type I ...
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Cell type-specific function of TRAF2 and TRAF3 in regulating type I IFN induction
... lates type I IFN induction by DNA viruses, such as HSV-1, through controlling the noncanonical NF-κB inducing kinase NIK ...and induction of type I IFNs ...STING ...
10
NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway
... and IFN-γ production in response to ...or IFN-β production in response to ...NOD1 induction of chemokines in gastrointestinal epithelial cells sup- port the conclusion that NOD1 signaling and ...
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Hemagglutinin of Influenza A Virus Antagonizes Type I Interferon (IFN) Responses by Inducing Degradation of Type I IFN Receptor 1
... circumvent type I interferon (IFN) responses, particularly by inhibiting the synthesis of type I ...the type I IFN receptor (IFNAR)-mediated signaling ...the ...
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Double-Stranded RNA Induces Biphasic STAT1 Phosphorylation by both Type I Interferon (IFN)-Dependent and Type I IFN-Independent Pathways
... MAVS-dependent pathway for initial STAT1 phosphorylation following the recognition of ...rapid induction of the innate antiviral response is critical for controlling viral rep- lication (9), it is essential ...
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Type III Interferon (IFN) Induces a Type I IFN-Like Response in a Restricted Subset of Cells through Signaling Pathways Involving both the Jak-STAT Pathway and the Mitogen-Activated Protein Kinases
... the type I or type III IFN receptor complex leads to induction of approximately the same subset of genes, one might ask why nature maintains two apparently redundant ...of type ...
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Identification of novel inhibitors of the type I interferon induction pathway using cell based high throughput screening
... the IFN induction ...the IFN induction ...signaling pathway provides the potential to identify novel compounds that target new or unknown pathway ...signaling pathway has ...
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Proteolysis of MDA5 and IPS 1 is not required for inhibition of the type I IFN response by poliovirus
... The type I IFN response was assessed by measuring IFN- β mRNA levels using qRT-PCR and normalizing to levels of β -actin ...the type I IFN response was examined by ...
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Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production
... producing type I inter- feron ...the induction of IFN- b transcription and IFN-b secretion by the dying ...elevated IFN- b levels in ...of type I ...
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NS3 of Bluetongue Virus Interferes with the Induction of Type I Interferon
... TLR-independent pathway is preferentially used in plasmacytoid dendritic cells (pDCs) ...As IFN-I is detrimental for viral replication, most viruses have evolved mech- anisms to counteract the host ...
6
An alphavirus nsP1 determinant modulates type I Interferon induction
... induce IFN activation through the RIG-I, MDA-5, and PKR RNA receptors via the IPS-1 signaling ...the IFN induction pool mediated by the wild type RRV virus, we demonstrate that the RRV ...
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Original Article MicroRNA-221 inhibits human papillomavirus 16 E1-E2 mediated DNA replication through activating SOCS1/Type I IFN signaling pathway
... the induction of IFN α and IFN β by miR-221 mimics at both mRNA level and protein levels was significantly reduced by transfection of pcDNA-SOCS1 (Figure 6C, ...promoting type I ...
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Type I interferon (IFN)-inducible Absent in Melanoma 2 proteins in neuroinflammation: implications for Alzheimer’s disease
... ISD pathway by caspase- 1-mediated pyroptotic cell death ...T1 IFN- inducible IFI205 protein and inhibited the IFI205- mediated induction of IFN-β through activation of ISD pathway ...
10
Toscana Virus NSs Protein Inhibits the Induction of Type I Interferon by Interacting with RIG-I
... of IFN- pro- ...counteracted IFN- production by in- hibiting IRF-3 phosphorylation and activation without affecting its expression and nuclear accumulation (9), suggesting that NSs could block a very ...
8
Induction of MxA Gene Expression by Influenza A Virus Requires Type I or Type III Interferon Signaling
... MxA induction is dependent on type I and III IFNs and a functional IFN-stim- ulated signaling ...activated IFN regulatory factors is suppressed due to the restrictive control of ...
10
MDA5 Localizes to Stress Granules, but This Localization Is Not Required for the Induction of Type I Interferon
... the induction of both IFN- ␣/ and the stress pathways suggested a possible link between these two antiviral ...RLR pathway does not lead to SG ...recombinant IFN-treated HeLa and MEF ...of ...
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Wild type measles virus attenuation independent of type I IFN
... Parks et al. sequenced a number of the vaccine strains derived from the Edmonston isolate and identified amino acids shared by these attenuated viruses [31]. Eight amino acid coding changes were common to all vaccine ...
12
Ross River Virus Interaction with the Type I IFN Pathways
... enhanced type I IFN sensitivity (Stoermer Burrack et ...importantly, type I IFN response at early stages of infection is critical for RRV disease ...alter type I ...
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Studies on interferon (IFN) induction and isolation of IFN inducing mutant viruses
... subunit type vaccines are they are unlikely to trigger an adverse reaction, and subunit vaccines are not infectious, so that they can be applied to immunosuppressed ...
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