Type I Interferon
Human Rhinovirus Attenuates the Type I Interferon Response by Disrupting Activation of Interferon Regulatory Factor 3
... induce interferon-  mRNA synthesis or activation of the Jak/STAT ...the type I interferon response via the produc- tion of IFN-  ...of type I IFN-stimulated genes (ISGs), thus ...
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Genetic associations in type I interferon related pathways with autoimmunity
... by type I interferons Although some genes and their products may not directly participate in the signalling from the interferon type I receptors, they still may be regulated by ...
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Type I interferon in organ targeted autoimmune and inflammatory diseases
... of interferon is high; in the setting of the in vivo stimuli that characterize MS, IFNAR1 expression and signaling through TLR4 are not reduced in the nonresponders as they are in the responders; and capacity to ...
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Dual Modulation of Type I Interferon Response by Bluetongue Virus
... Bluetongue virus (BTV) is a double-stranded RNA (dsRNA) virus that causes an economically important disease in ruminants. BTV infection is a strong inducer of type I interferon (IFN-I) in ...
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FOSL1 Inhibits Type I Interferon Responses to Malaria and Viral Infections by Blocking TBK1 and TRAF3/TRIF Interactions
... gene I (RIG-I), melanoma differentiation-associated gene 5 (MDA5), cyclic GMP-AMP synthase (cGAS), Toll-like receptors (TLRs), and NOD-like receptors (NLRs) (1, ...of interferon genes (STING, also ...
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Interferon Regulatory Factor 1 and Type I Interferon Cooperate To Control Acute Gammaherpesvirus Infection
... pathology. Interferon regulatory factor 1 (IRF-1) is a tumor suppressor that is also involved in the regulation of innate and adaptive im- mune ...that type I interferon (IFN) and IRF-1 ...
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Salmonella Suppresses the TRIF Dependent Type I Interferon Response in Macrophages
... including type I interferon (IFN) production, inflammasome signaling, and signaling of reti- noic acid-inducible gene I (RIG-I)-like helicase receptors (RLRs) ...(21). Type ...
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The Type I Interferon Response Determines Differences in Choroid Plexus Susceptibility between Newborns and Adults in Herpes Simplex Virus Encephalitis
... the type I interferon (IFN) response reduces viral replication and improves survival in the adult (5), it does not contribute to sur- vival following HSV infection in the newborn brain ...the ...
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Suppression of Type I Interferon Signaling by E1A via RuvBL1/Pontin
... antiviral interferon response (reviewed in reference ...suppress type I interferon-inducible gene expres- sion via its N terminus/CR1 region ...by type II IFN (IFN- ␥ ) and IFN-  mRNA ...
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Vaccinia Virus-Mediated Inhibition of Type I Interferon Responses Is a Multifactorial Process Involving the Soluble Type I Interferon Receptor B18 and Intracellular Components
... Poxviruses such as virulent vaccinia virus (VACV) strain Western Reserve encode a broad range of immune modulators that interfere with host responses to infection. Upon more than 570 in vitro passages in chicken embryo ...
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An alphavirus nsP1 determinant modulates type I Interferon induction
... wild type virus, though both viruses exhibited equivalent levels of 26S RNA synthesis by 4-6 hours post-infection ...in type I IFN ...wild type virus (data not shown). In this model, the wild ...
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Activation of the Chicken Type I Interferon Response by Infectious Bronchitis Coronavirus
... the type I interferon (IFN) response is an essential defense mechanism against ...the type I IFN response, here referred to as the IFN response, is initiated upon the activation of host ...
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Differential Type I Interferon Signaling Is a Master Regulator of Susceptibility to Postinfluenza Bacterial Superinfection
... of type I IFNs in a mechanism associated with susceptibility to bacterial superinfection over the course of IAV ...of type I IFNs (36, 48, 49), suggesting that there is spec- ificity in the ...
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Differential Inhibition of Type I Interferon Induction by Arenavirus Nucleoproteins
... FIG. 3. Induction of type I IFN is not inhibited in TCRV-infected A549 cells. (A) A549 cells are susceptible to TCRV infection. A549 cells were infected with either LCMV or TCRV at a MOI of 2, and 72 h ...
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Epstein-Barr Virus LF2: an Antagonist to Type I Interferon
... S479D as effectively as that of wild-type IRF7 (Fig. 3C). Fur- thermore, LF2 did not affect IR7 nuclear translocation because LF2 is localized in the nucleus as well (Fig. 4). Finally, despite the fact that IRF7 ...
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The role of PML proteins in adenovirus type 5 infection and the type I interferon response
... overcome by examining the effects of Orf3 expression in HEK293 cells, which are readily transfectable and expressed Orf3 to high levels. That no change was detected in either cell type suggests that E4 Orf3 may ...
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Virus Multiplicity of Infection Affects Type I Interferon Subtype Induction Profiles and Interferon-Stimulated Genes
... sub- type profiles in cultures infected with either ...by type I IFNs that lead to ISG induction have been studied extensively in the literature and in- clude the MAPK and PKR pathways (28, ...
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Evasion of the Innate Immune Type I Interferon System by Monkeypox Virus
... The vaccinia virus (VACV) E3 protein has been shown to be important for blocking activation of the cellular innate im- mune system and allowing viral replication to occur unhindered. Mutation or deletion of E3L severely ...
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Type I Interferon Signals in Macrophages and Dendritic Cells Control Dengue Virus Infection: Implications for a New Mouse Model To Test Dengue Vaccines
... the type I IFNR on different subsets of immune cells and com- pared their responses to DENV2 infection and immunization with a candidate subunit ...the type I IFN receptor on both LysM- and ...
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Antagonism of Type I Interferon Responses by New World Hantaviruses
... alpha interferon (IFN- ␣ ) and IFN-  and antiviral immune defenses ...are type I integral membrane glycoproteins characterized by extracellular domains contain- ing various numbers of leucine-rich ...
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