Type I Interferon Receptor
Pseudorabies Virus dUTPase UL50 Induces Lysosomal Degradation of Type I Interferon Receptor 1 and Antagonizes the Alpha Interferon Response
... of type I IFN signaling through an unbiased screen, which was a surprising result because the primary function of dUTPase is associated with dUTP metabolism, but it was not ...
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Vaccinia Virus-Mediated Inhibition of Type I Interferon Responses Is a Multifactorial Process Involving the Soluble Type I Interferon Receptor B18 and Intracellular Components
... of type I IFNs is mediated by newly synthesized viral proteins expressed early in the viral life cycle ...with type I IFN induction during virus ...functional type I IFN system ...
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In Vivo Ablation of Type I Interferon Receptor from Cardiomyocytes Delays Coxsackieviral Clearance and Accelerates Myocardial Disease
... activates interferon-stimulated gene (ISG) expression in car- diomyocytes (infected and uninfected); this short burst of sys- temic T1IFN should dramatically upregulate the production of T1IFNs by infected ...
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Type I interferon receptor in peripheral blood mononuclear cells may predict response to intra-arterial 5-fluorouracil + interferon therapy for advanced hepatocellular carcinoma
... IFNAR2 mRNA expression in peripheral blood mononuclear cells was significantly higher in responders (complete response or partial response) than in nonresponders (stable disease or[r] ...
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Rapid Expansion of CD8+ T Cells in Wild-Type and Type I Interferon Receptor-Deficient Mice Correlates with Protection after Low-Dose Emergency Immunization with Modified Vaccinia Virus Ankara
... Determination of ECTV loads in mouse organs. Organs (lungs, liv- ers, and spleens) were removed under aseptic conditions from sacrificed or dead mice. The organs were frozen and subsequently thawed, weighed, and ...
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Transcriptomic Analysis Reveals a Mechanism for a Prefibrotic Phenotype in STAT1 Knockout Mice during Severe Acute Respiratory Syndrome Coronavirus Infection
... the type I interferon receptor was associated with changes in host gene expression with respect to the immune response and ...of interferon lambda signaling, but only modest induction ...
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FOSL1 Inhibits Type I Interferon Responses to Malaria and Viral Infections by Blocking TBK1 and TRAF3/TRIF Interactions
... gene I (RIG-I), melanoma differentiation-associated gene 5 (MDA5), cyclic GMP-AMP synthase (cGAS), Toll-like receptors (TLRs), and NOD-like receptors (NLRs) (1, ...of interferon genes (STING, also ...
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NS3 of Bluetongue Virus Interferes with the Induction of Type I Interferon
... Toll-like receptor 3 (TLR3) and TLR7 or by RIG-I and MDA5, members of the RIG-I-like receptor (RLR) family (11, ...as interferon (IFN) regulatory factor 3 (IRF-3) and IRF-7 or nuclear ...
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Porcine Epidemic Diarrhea Virus-Induced Epidermal Growth Factor Receptor Activation Impairs the Antiviral Activity of Type I Interferon
... factor receptor (EGFR) activation, which has been linked to not only anticancer therapeutics, but also antiviral ...of type I interferon ...of interferon and resulted in decreased PEDV ...
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Salmonella Suppresses the TRIF Dependent Type I Interferon Response in Macrophages
... ABSTRACT Salmonella enterica is an intracellular pathogen that causes diseases ranging from gastroenteritis to typhoid fever. Salmonella bacteria trigger an autophagic response in host cells upon infection but have ...
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Epidermal growth factor receptor inhibitors trigger a type I interferon response in human skin
... the type I IFN response, including transcription factors (STAT1, STAT2) and a number of effectors of the innate antiviral response [28, 29] (Table ...
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Epigenetic Suppression of Interferon Lambda Receptor Expression Leads to Enhanced Human Norovirus Replication In Vitro
... for type I and III interferon induction, upregulation of IRF3- dependent genes suggests that HuNoV replication produces PAMPs that are sensed by RIG-I-like receptor(s), which in turn ...
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Toll like receptor 3 upregulation by type I interferon in healthy and scleroderma dermal fibroblasts
... of type I inter- feron (IFN) pathways similar to those seen in patients with systemic lupus erythematosus (SLE) ...a type I IFN signature in patients with SSc ...a type I IFN ...
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Modified Vaccinia Virus Ankara Induces Toll-Like Receptor-Independent Type I Interferon Responses
... of type I IFN ...gene I protein (RIG-I), that play a role in activation of DC have been ...vate type I IFN responses in a TLR9-independent and IFN regulatory factor 3 ...
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Toll-like receptor agonists partially restore the production of pro-inflammatory cytokines and type I interferon in Sézary syndrome
... evaluating type I and type III IFN expression in PBMC, some patients exhibited a constitutive increase in these IFNs (patients 1, 4 and 9) that was not due to seropositivity for viral ...
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Baculovirus Induces Type I Interferon Production through Toll-Like Receptor-Dependent and -Independent Pathways in a Cell-Type-Specific Manner
... of type I IFN in response to viral infection through TLR-dependent and TLR- independent pathways (9, ...virus type 1 (HSV-1) (15) produces type I IFN through both TLR-dependent and ...
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Systemic lupus erythematosus and the type I interferon system
... Toll-like receptor 9 (TLR9), mediating IFN- α synthesis induced by CpG-DNA, but the role of this receptor for the response to IICs is ...to type 1 DCs; both cell types express the co-stimulatory ...
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Inhibition of type I and type II interferon signaling by alphavirus nonstructural proteins
... The type I interferons (IFNs) α and β represent a crucial innate defense system against most viral pathogens, including ...the type I IFNs bind the interferon α/β receptor ...
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Type I Interferon Signals in Macrophages and Dendritic Cells Control Dengue Virus Infection: Implications for a New Mouse Model To Test Dengue Vaccines
... the type I IFNR on different subsets of immune cells and com- pared their responses to DENV2 infection and immunization with a candidate subunit ...the type I IFN receptor on both LysM- ...
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Hemagglutinin of Influenza A Virus Antagonizes Type I Interferon (IFN) Responses by Inducing Degradation of Type I IFN Receptor 1
... Real-time PCR. Total cellular RNA was purified using Tri Reagent (Sigma-Aldrich) according to the manufacturer’s instructions and was treated with DNase I (Thermo Scientific) to remove contaminated DNAs. The RNA ...
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