Type I interferon signaling
Suppression of Type I Interferon Signaling by E1A via RuvBL1/Pontin
... of interferon signaling is of paramount importance to a vi- ...rus. Interferon signaling significantly reduces or halts the ability of a virus to repli- cate; therefore, viruses have evolved ...
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Rhesus Macaque Rhadinovirus Encodes a Viral Interferon Regulatory Factor To Disrupt Promyelocytic Leukemia Nuclear Bodies and Antagonize Type I Interferon Signaling
... isoforms I and/or II are decreased following WT RRV infection, and this is depen- dent on R12 protein ...receptor signaling, during exogenous R12-FLAG protein ...
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Type I Interferon Signaling Prevents Hepatitis B Virus-Specific T Cell Responses by Reducing Antigen Expression
... Type I interferons (IFN-Is), which include several IFN- ␣ proteins and one IFN-  protein, are key molecules mediating innate immune responses ...IFN-I signaling in the induction of ...
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Differential Type I Interferon Signaling Is a Master Regulator of Susceptibility to Postinfluenza Bacterial Superinfection
... of type I IFNs in a mechanism associated with susceptibility to bacterial superinfection over the course of IAV ...of type I IFNs (36, 48, 49), suggesting that there is spec- ificity in the ...
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Role of Type I Interferon Signaling in Human Metapneumovirus Pathogenesis and Control of Viral Replication
... FIG 6 Expression of PD-L1 is driven by, but not dependent on, type I IFN signaling in lung epithelial cells and CD11c ⫹ DCs. WT and IFNAR ⫺/⫺ mice were infected with HMPV, and at 5 (A, C) or 10 (B, ...
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Caspase-Dependent Suppression of Type I Interferon Signaling Promotes Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication
... inducible RTA transgene to allow for robust reactivation (39). To quantify virus produc- tion, we exposed uninfected iSLK.RTA cells to the supernatant of reactivated TREx- BCBL1-RTA cells treated with vehicle or ...
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Hepatitis C Virus NS5A Disrupts STAT1 Phosphorylation and Suppresses Type I Interferon Signaling
... Jak-STAT1 signaling pathway, including IFN-induced ISRE pro- moter activity, P-STAT1 levels, and downstream ISG ...ISRE signaling, P-STAT1 levels, and ISG ...IFN signaling than did the GT3a and GT3b ...
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Blocking type I interferon signaling enhances T cell recovery and reduces HIV 1 reservoirs
... human immune system (hu-mice) for modeling HIV-1 infection and immunopathogenesis (26, 27). We and others have previously reported that persistent HIV-1 infection in hu-mice led to induc- tion of IFN-I ...
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ISG15 Modulates Type I Interferon Signaling and the Antiviral Response during Hepatitis E Virus Replication
... High levels of ISG15 expression have been reported in HEV infections of chimpanzee liver tissues (28), in patients with chronic HEV infection (25), and in other persistent hepatic viral infections (24). In vitro studies ...
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Streptococcus pneumoniae DNA Initiates Type I Interferon Signaling in the Respiratory Tract
... of type I IFN signaling in the host response to pneumococcal infection has been previously reported by Weigent et ...of type I IFN signaling in ...of type I ...
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Porcine Deltacoronavirus nsp5 Antagonizes Type I Interferon Signaling by Cleaving STAT2
... of type I IFN signaling. Type I IFN signaling induces a potent antiviral state by enhancing the expression of hundreds of ISGs, which are critical for controlling viral ...
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Type I Interferon Signaling to Dendritic Cells Limits Murid Herpesvirus 4 Spread from the Olfactory Epithelium
... IFNAR signaling to CD11c ⴚ lysM ⴙ cells limits MuHV-4 spleen infection. We gave MHV-GFP i.n. to CD11c-cre ⫻ flox-IFNAR and lysM-cre ⫻ flox-IFNAR mice, either in 30 l with anesthesia (lung infection) or in 5 l ...
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The Many Faces of the Flavivirus NS5 Protein in Antagonism of Type I Interferon Signaling
... The genus Flavivirus includes 53 currently recognized species (www.ictvonline.org) of which 40 are known to cause disease in humans (21). Some of the more well-known human pathogens from this group are dengue virus ...
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Inhibition of type I interferon signaling abrogates early Mycobacterium bovis infection
... on Type I IFN receptor blocking antibodies, allowed us to examine how Type I IFN signal- ing affects lung myeloid cell populations during ...that Type I IFN produced locally in ...
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Type I interferon and pattern recognition receptor signaling following particulate matter inhalation
... increased type I interferon signaling contrib- ute to the toxicological effects of GMA-SS? One poten- tial role for Irf7 is ...related type I interferon signaling ...
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Original Article Application of weighted gene co-expression network analysis to rheumatoid arthritis
... the type I interferon signaling ...the type I interferon signaling pathway possibly play critical roles in RA ...
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FOSL1 Inhibits Type I Interferon Responses to Malaria and Viral Infections by Blocking TBK1 and TRAF3/TRIF Interactions
... PI3K/AKT signaling pathway that operates by affecting the expression of genes associated with the invasive-vascular remodeling trophoblast phenotype and is responsible for the development of trophoblast lineages ...
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Rubicon Modulates Antiviral Type I Interferon (IFN) Signaling by Targeting IFN Regulatory Factor 3 Dimerization
... inhibits type I IFN signaling and transcription of IFN-related ...the type I IFN signaling pathway, we confirmed phosphorylation of molecules (p65, STAT1, ERK, and p38) involved ...
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Proapoptotic signaling induced by RIG I and MDA 5 results in type I interferon–independent apoptosis in human melanoma cells
... antiviral signaling pathway initiated by RIG-I and MDA-5 that activates proapoptotic signaling and, unless blocked by Bcl-x L , results in ...
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The regulation of type I interferon production by paramyxoviruses
... IFN signaling. However, blocking IFN signaling alone is not suffi cient to allow these viruses to fully circumvent the IFN response because if a virus only blocked IFN signaling, infected cells may ...
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