Type II collagen-induced arthritis
Interleukin 10 expression and chemokine regulation during the evolution of murine type II collagen induced arthritis
... of type II collagen-induced arthritis ...initial type II collagen challenge, while increases in IL-10 were found between days 36 and ...
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Effect of Saururus chinensis leaves extract on type II collagen induced arthritis mouse model
... According to existing literature, current treatment strat- egies for RA are focused on improvement of joint damage and inflammatory response including swelling and fever. Thus, therapeutic agents for RA include ...
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Nature and specificity of the immune response to collagen in type II collagen induced arthritis in mice
... of collagen. The maximal proliferative response to collagen occurred at 2 wk after ...denatured type II collagen or type I ...
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THE ANTI ARTHRITIC POTENTIAL OF BARBADOS NUT JATROPHA CURCAS LINN (1753) LEAF EXTRACT IN BOVINE TYPE II COLLAGEN INDUCED ARTHRITIS IN MALE ALBINO MICE MUS MUSCULUS
... rheumatoid arthritis (RA), nowadays is very ...of arthritis as diagnosed by a doctor, one in 20 ...to arthritis, and by 2040, an estimated 78 million (26%) US adults ages 18 years or older are ...
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Passive Transfer by Cells of Type II Collagen Induced Arthritis in Rats
... with type I collagen in ...solubilized type II collagen to unsensitized cells at the time of transfer or injection of heat-killed sensitized cells also did not cause arthritis in ...
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Humoral and Cellular Sensitivity to Collagen in Type II Collagen Induced Arthritis in Rats
... developed type-specific cellular as well as humoral ...was type II. The latter collagen induced brisk cellular and humoral responses that were equivalent whether complete Freund's ...
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Modulation of collagen induced arthritis by adenovirus mediated intra articular expression of modified collagen type II
... of collagen peptides to act locally to induce T cells to secrete suppressive cytokines in a limited environment makes them interesting as potential therapeutic reagents in suppressing ...
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Transplantation of gingiva derived mesenchymal stem cells ameliorates collagen induced arthritis
... in collagen-induced arthritis (CIA) mice via a Fas/FasL ...b Arthritis severity scores were determined at various time points after ...c Arthritis severity score system using a 5-point ...
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T cells that are naturally tolerant to cartilage derived type II collagen are involved in the development of collagen induced arthritis
... to arthritis to the same extent as nonthymectomized ...of arthritis, and to exclude a role for nontolerized recent thymic T-cell emigrants in the development of ...mouse collagen) that has been ...
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A crucial role for tumor necrosis factor receptor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis
... bovine collagen type II; BMC: bone marrow cell; BSA: bovine serum albumin; CIA: collagen-induced arthritis; Ct: cycle threshold; DC: dendritic cell; DMEM: Dulbecco's modified ...
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Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II induced arthritis
... HMGB1 is an endogenous pathogenic factor in synovitis, and the present results that oxaliplatin-induced nuclear HMGB1 sequestration coincided with beneficial therapy outcome sup- port this notion. Several research ...
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Chronic development of collagen induced arthritis is associated with arthritogenic antibodies against specific epitopes on type II collagen
... In the present experiments, in which we used only mice expressing the MHC class II molecule Aq, it is likely that the same B and T cell epitopes are recognized. A difference could be that the affinity for the T ...
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OX40 signaling is involved in the autoactivation of CD4+CD28− T cells and contributes to the pathogenesis of autoimmune arthritis
... Acute collagen-induced arthritis; APC: Antigen-presenting cell; CCK-8: Cell Counting Kit-8; CIA: Collagen-induced arthritis; C-CIA: Chronic collagen-induced ...
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Collagen induced arthritis in C57BL/6 mice is associated with a robust and sustained T cell response to type II collagen
... all induced disease, with an incidence of 80% to ...of collagen preparation, or substrains of B6 mice, and it is impor- tant to note that our study was carried out with B6 mice pur- chased from Harlan UK, ...
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Soluble PD 1 aggravates progression of collagen induced arthritis through Th1 and Th17 pathways
... immune arthritis in mice with ...mouse type II colla- gen were increased in PD-1-Fc-treated CIA mice, and levels of Th1 and Th17 cells were increased in the spleen, suggesting that the T cells may ...
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Arthritis induced in rats by cloned T lymphocytes responsive to mycobacteria but not to collagen type II
... adjuvant arthritis in rats using a long-term cell line of T lymphocytes, the A2 line, which can induce polyarthritis and can also be used to vaccinate rats against adjuvant ...to collagen type ...to ...
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Adoptive transfer of suppression of arthritis in the mouse model of collagen induced arthritis Evidence for a type II collagen specific suppressor T cell
... of collagen-induced ...native type II collagen 3 d before immunization with native type II collagen emulsified in complete Freund's adjuvant resulted in animals ...
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Interleukin 7 aggravated joint inflammation and tissue destruction in collagen induced arthritis is associated with T cell and B cell activation
... CIA: collagen-induced arthritis; CII: chicken collagen type II; DN: double negative; DP: double positive; EGF: epidermal growth factor; FGF: fibroblast growth factor; HE: ...
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A 4 trifluoromethyl analogue of celecoxib inhibits arthritis by suppressing innate immune cell activation
... of arthritis, including CIA and type II collagen antibody-induced arthritis (CAIA), in contrast to the limited inhibitory effect of ...
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Statins accelerate the onset of collagen type II induced arthritis in mice
... of collagen-induced arthritis Male DBA/1OlaHsd mice were obtained from Harlan (Horst, the ...and arthritis severity were assessed three times per week in a blinded manner, using a ...
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