Type III IFN induction
Lambda Interferon (IFN-λ), a Type III IFN, Is Induced by Viruses and IFNs and Displays Potent Antiviral Activity against Select Virus Infections In Vivo
... potent IFN-inducing potential of most RNA viruses, although it ought to be mentioned that such strong induction has been found in some (13), but not all, studies with RNA ...expected, IFN-  was ...
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Induction of MxA Gene Expression by Influenza A Virus Requires Type I or Type III Interferon Signaling
... in IFN production or the STAT1 gene, we studied the induction profile of MxA by real-time reverse transcriptase ...the IFN system because NS1 acts as a viral IFN-antagonistic ...of IFN ...
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Type III Interferon (IFN) Induces a Type I IFN-Like Response in a Restricted Subset of Cells through Signaling Pathways Involving both the Jak-STAT Pathway and the Mitogen-Activated Protein Kinases
... the type I or type III IFN receptor complex leads to induction of approximately the same subset of genes, one might ask why nature maintains two apparently redundant ...of type I ...
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Toll-Like Receptor Expression and Induction of Type I and Type III Interferons in Primary Airway Epithelial Cells
... differential IFN production in specific cell populations other than antigen- presenting cells have not yet been fully ...of type I (IFN-␣/) and type III (IFN-) ...AECs. ...
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Alpha/Beta Interferon (IFN-α/β)-Independent Induction of IFN-λ1 (Interleukin-29) in Response to Hantaan Virus Infection
... strong induction of IFN- that occurred prior to induction of MxA and IFN-  in response to HTNV infec- tion in A549 ...Furthermore, IFN- 1 and MxA were in- duced in HTNV-infected ...
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Expression of Type III Interferon (IFN) in the Vaginal Mucosa Is Mediated Primarily by Dendritic Cells and Displays Stronger Dependence on NF-κB than Type I IFNs
... of type III IFN during vaginal infection with HSV-2 or treatment with a TLR9 agonist, and the ability of DCs to induce IFN- expression was largely dependent on a functional NF- B ...to ...
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Induction of Dendritic Cell Production of Type I and Type III Interferons by Wild-Type and Vaccine Strains of Measles Virus: Role of Defective Interfering RNAs
... DI RNAs played a major role in the induction of IFN by MeV- infected moDCs. Despite low-MOI passage, we detected DI RNA in most of our vaccine stocks and some WT stocks, including the stock of the Chicago-1 ...
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HOIL1 Is Essential for the Induction of Type I and III Interferons by MDA5 and Regulates Persistent Murine Norovirus Infection
... events at downstream steps to ensure tight regulation of the RLR pathways and IFN production. One potential caveat to our findings is that the cell types used in this study express truncated forms of HOIL1, albeit ...
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Induction of an Antiviral State and Attenuated Coxsackievirus Replication in Type III Interferon-Treated Primary Human Pancreatic Islets
... (including type III IFN) during the development of type 1 diabetes will need to be addressed in future ...the type III IFN receptor and that they respond to type ...
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Rotavirus Degrades Multiple Interferon (IFN) Type Receptors To Inhibit IFN Signaling and Protects against Mortality from Endotoxin in Suckling Mice
... multiple IFN types is not well ...deplete IFN type I, II, and III receptors ...regulating IFN induction. In suckling mice, exogenously administered type I, II, or ...
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Cell type-specific function of TRAF2 and TRAF3 in regulating type I IFN induction
... lates type I IFN induction by DNA viruses, such as HSV-1, through controlling the noncanonical NF-κB inducing kinase NIK ...and induction of type I IFNs ...promoted type I ...
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TRAM is required for TLR2 endosomal signaling to type I IFN induction
... the induction of pro- inflammatory cytokines such as TNF-α, via activation of ...the induction of type I IFNs via IFN regulatory factors ...and type I ...impaired induction of ...
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Studies on interferon (IFN) induction and isolation of IFN inducing mutant viruses
... subunit type vaccines are they are unlikely to trigger an adverse reaction, and subunit vaccines are not infectious, so that they can be applied to immunosuppressed ...
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The type I IFN induction pathway constrains Th17 mediated autoimmune inflammation in mice
... the induction of IL-27. Even though type I IFN–mediated IL-27 production plays a criti- cal role in limiting Th17 development and autoimmune response, this finding does not exclude the possibility ...
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Wild type measles virus attenuation independent of type I IFN
... Parks et al. sequenced a number of the vaccine strains derived from the Edmonston isolate and identified amino acids shared by these attenuated viruses [31]. Eight amino acid coding changes were common to all vaccine ...
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Hemagglutinin of Influenza A Virus Antagonizes Type I Interferon (IFN) Responses by Inducing Degradation of Type I IFN Receptor 1
... cape type I IFNs’ antiviral activity by desensitizing cells to IFNs, ...targeting type I IFN recep- tor for ...repress IFN re- ceptor-mediated JAK/STAT signaling, which would create a cel- ...
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NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway
... and IFN-γ production in response to ...or IFN-β production in response to ...NOD1 induction of chemokines in gastrointestinal epithelial cells sup- port the conclusion that NOD1 signaling and ...
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Double-Stranded RNA Induces Biphasic STAT1 Phosphorylation by both Type I Interferon (IFN)-Dependent and Type I IFN-Independent Pathways
... RIG-I/MAVS-dependent and RIG-I/MAVS-independent signaling in STAT1 phosphorylation. To examine the involve- ment of MAVS in RIG-I-mediated STAT1 phosphorylation, we attempted to cotransfect A549 cells with the RIG-I-CARD ...
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Rubicon Modulates Antiviral Type I Interferon (IFN) Signaling by Targeting IFN Regulatory Factor 3 Dimerization
... The type I IFN system is a critical innate immune response that pro- tects organisms against virus ...However, type I IFN signaling must be tightly regulated to avoid excessive production of ...
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Effects of quercetin nanoliposomes on C6 glioma cells through induction of type III programmed cell death
... from induction of stress proteins, including the heat shock proteins, disruption of microtubules, mitochondrial release of cytochrome c, and activation of ...
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