Type III secretion
Role of Autocleavage in the Function of a Type III Secretion Specificity Switch Protein in Salmonella enterica Serovar Typhimurium
... during secretion of its substrates, the type III secretion machine functions in a hierarchi- cal ...the secretion of the effector proteins and the proteins necessary for their ...
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Type III Secretion of ExoU Is Critical during Early Pseudomonas aeruginosa Pneumonia
... early secretion of ExoU is truly critical for the pathogenesis of pneumonia caused by ...and secretion of this toxin during infection in a mouse model of ...and secretion of ExoU is no longer capable ...
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Immunodominant Regions of a Chlamydia trachomatis Type III Secretion Effector Protein, Tarp
... chlamydial type III secretion effector molecule, Tarp (translocated actin-recruiting phosphoprotein), has been found to have a critical role in chlamydial invasion of nonphagocytic epithelial cells ...
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Structure of a bacterial type III secretion system in contact with a host membrane in situ
... Many bacterial pathogens of animals and plants use a conserved type III secretion system (T3SS) to inject virulence effector proteins directly into eukaryotic cells to subvert host functions. Contact ...
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Escherichia coli type III secretion system 2: a new kind of T3SS?
... for secretion and translocation of SopE and SopE2 and for stabilization of SopE2 in the bacterial cytosol ...the type III secretion apparatus ...functional secretion system in EHEC O157 ...
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Enterococcus faecalis Enhances Expression and Activity of the Enterohemorrhagic Escherichia coli Type III Secretion System
... EHEC expresses two major virulence factors: Shiga toxin, which is responsible for the kidney damage associated with EHEC infection, and a type III secretion system (T3SS), which is required for ...
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Identification of Mammalian Proteins That Collaborate with Type III Secretion System Function: Involvement of a Chemokine Receptor in Supporting Translocon Activity
... In this study, an RNA interference (RNAi) knockdown screen was performed in order to investigate the contribution of the host cell during type III secretion. Combining fluorescence resonance energy ...
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The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses.
... by secretion of IL-22, in the absence of which mice succumbed to the ...a type III secretion system (T3SS) that injects effectors into colonic intestinal epi- thelial cells ...as ...
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The Structure of an Injectisome Export Gate Demonstrates Conservation of Architecture in the Core Export Gate between Flagellar and Virulence Type III Secretion Systems
... irulence-associated type III secretion systems (T3SS), also termed injectisomes, are bacterial nanomachines that facilitate the delivery of effector proteins directly into a eukaryotic host cell ...
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EspZ of Enteropathogenic and Enterohemorrhagic Escherichia coli Regulates Type III Secretion System Protein Translocation
... IMPORTANCE Enteropathogenic Escherichia coli (EPEC) and enterohemorrhagic E. coli (EHEC) are important diarrheal patho- gens responsible for significant morbidity and mortality in developing countries and the developed ...
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Making connections: snapshots of chlamydial type III secretion systems in contact with host membranes
... During the early stages of infection, extracellular infec- tious but metabolically inactive elementary bodies (EBs) adhere to the plasma membrane of the host cell and induce their own actin-dependent uptake into ...
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Solving the supply of Resveratrol Tetramers from Papua New Guinean rainforest Anisoptera species (Dipterocarpaceae) that inhibit bacterial type III secretion systems
... virulence type III secretion system (T3SS) identified several fractions derived from two Papua New Guinean Anisoptera species, showing activity against Yersinia pseudotuberculosis outer proteins E ...
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Identification of Salmonella Pathogenicity Island 2 Type III Secretion System Effectors Involved in Intramacrophage Replication of S enterica Serovar Typhimurium: Implications for Rational Vaccine Design
... ABSTRACT Salmonella enterica serovars cause severe diseases in humans, such as gastroenteritis and typhoid fever. The develop- ment of systemic disease is dependent on a type III secretion system ...
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Piericidin A1 Blocks Yersinia Ysc Type III Secretion System Needle Assembly
... the secretion of middle and late T3SS substrates, it does not decrease effector protein expression but instead causes an accumulation of effectors in the bacterial ...subsequent secretion out of the ...
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Chemical Targeting and Manipulation of Type III Secretion in the Phytopathogen Xanthomonas campestris for Control of Disease
... Numerous Gram-negative bacterial plant pathogens, including Pseudomonas, Er- winia, and Xanthomonas species, utilize type III secretion systems (T3SSs) to inject effector proteins directly into host ...
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A Phosphorylation Switch on Lon Protease Regulates Bacterial Type III Secretion System in Host
... IMPORTANCE Type III secretion systems (T3SS) are an essential virulence trait of many bacterial pathogens because of their indispensable role in the delivery of viru- lence ...
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Microbiota and Pathogen Proteases Modulate Type III Secretion Activity in Enterohemorrhagic Escherichia coli
... a type III secretion system (T3SS), which is a syringe-like apparatus used to inject bacterial effectors into the host cell that either mimic or hijack host cell function ...
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Selective Purification of Recombinant Neuroactive Peptides Using the Flagellar Type III Secretion System
... ABSTRACT The structure, assembly, and function of the bacterial flagellum involves about 60 different proteins, many of which are selectively secreted via a specific type III secretion system (T3SS) ...
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Structure of HrcQ(B)-C, a conserved component of the bacterial type III secretion systems
... gens to deliver virulence proteins into the cytosol of eukaryotic host cells, causing a broad spectrum of diseases including bacte- remia, septicemia, typhoid fever, and bubonic plague in mammals, and localized lesions, ...
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Dynamics of the Type III Secretion System Activity of Enteropathogenic Escherichia coli
... ABSTRACT Type III secretion systems (TTSSs) are employed by pathogens to translocate host cells with effector proteins, which are crucial for ...
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