Type III secretion (T3S)
Role of Autocleavage in the Function of a Type III Secretion Specificity Switch Protein in Salmonella enterica Serovar Typhimurium
... during secretion of its substrates, the type III secretion machine functions in a hierarchi- cal ...the secretion of the effector proteins and the proteins necessary for their ...
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Immunodominant Regions of a Chlamydia trachomatis Type III Secretion Effector Protein, Tarp
... chlamydial type III secretion effector molecule, Tarp (translocated actin-recruiting phosphoprotein), has been found to have a critical role in chlamydial invasion of nonphagocytic epithelial cells ...
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Dynamics of the Type III Secretion System Activity of Enteropathogenic Escherichia coli
... ABSTRACT Type III secretion systems (TTSSs) are employed by pathogens to translocate host cells with effector proteins, which are crucial for ...
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Identification of Mammalian Proteins That Collaborate with Type III Secretion System Function: Involvement of a Chemokine Receptor in Supporting Translocon Activity
... The type III secretion system (T3SS) is a highly conserved protein delivery system found in multiple Gram-negative pathogens, including Yersinia ...species type III intoxication of host ...
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Enterococcus faecalis Enhances Expression and Activity of the Enterohemorrhagic Escherichia coli Type III Secretion System
... The mechanism underlying enhanced LEE transcription in the presence of B. thetaiotaomicron has been described previously (6); however, the mechanism under- lying the effect of E. faecalis on LEE transcription is unknown, ...
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Escherichia coli type III secretion system 2: a new kind of T3SS?
... multiple type III secretion systems, with the first, Salmonella patho- genicity islands 1 (SPI-1) T3SS, playing a role in inva- sion into host cells, while the second, SPI-2 T3SS, is important for ...
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Structure of a bacterial type III secretion system in contact with a host membrane in situ
... trigger type III secretion in chlamydial elementary bodies 42 ...when secretion is activated in the absence of host cells 20 ...when secretion was induced artificially, supporting the ...
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EspZ of Enteropathogenic and Enterohemorrhagic Escherichia coli Regulates Type III Secretion System Protein Translocation
... ABSTRACT Translocation of effector proteins via a type III secretion system (T3SS) is a widespread infection strategy among Gram-negative bacterial pathogens. Each pathogen translocates a particular ...
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Type III Secretion of ExoU Is Critical during Early Pseudomonas aeruginosa Pneumonia
... early secretion of ExoU is truly critical for the pathogenesis of pneumonia caused by ...and secretion of this toxin during infection in a mouse model of ...and secretion of ExoU is no longer capable ...
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The Structure of an Injectisome Export Gate Demonstrates Conservation of Architecture in the Core Export Gate between Flagellar and Virulence Type III Secretion Systems
... irulence-associated type III secretion systems (T3SS), also termed injectisomes, are bacterial nanomachines that facilitate the delivery of effector proteins directly into a eukaryotic host cell ...
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Chemical Targeting and Manipulation of Type III Secretion in the Phytopathogen Xanthomonas campestris for Control of Disease
... Numerous Gram-negative bacterial plant pathogens, including Pseudomonas, Er- winia, and Xanthomonas species, utilize type III secretion systems (T3SSs) to inject effector proteins directly into host ...
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Piericidin A1 Blocks Yersinia Ysc Type III Secretion System Needle Assembly
... bacterial type III secretion system (T3SS) ...Protein secretion through this apparatus requires a proton motive force (11), as well as the ATPase YscN (12), and the ...
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Structure of HrcQ(B)-C, a conserved component of the bacterial type III secretion systems
... the type III secretion system, termed Hrp, is required for pathogenicity on susceptible plants and is also essential for induction of a defense reaction called the hyper- sensitive response, on ...
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The Citrobacter rodentium type III secretion system effector EspO affects mucosal damage repair and antimicrobial responses.
... by secretion of IL-22, in the absence of which mice succumbed to the ...a type III secretion system (T3SS) that injects effectors into colonic intestinal epi- thelial cells ...as ...
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Self Labeling Enzyme Tags for Analyses of Translocation of Type III Secretion System Effector Proteins
... bacterial type III secretion systems using SLEs as ...bacterial secretion systems in bacterial cells (9, 14) and as universal markers for correlative light and electron microscopy ...
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Control of Type III Secretion System Effector/Chaperone Ratio Fosters Pathogen Adaptation to Host Adherent Lifestyle
... ABSTRACT The transition from a planktonic lifestyle to a host-attached state is of- ten critical for bacterial virulence. Upon attachment to host cells, enteropathogenic Escherichia coli (EPEC) employs a type ...
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Negative Autogenous Control of the Master Type III Secretion System Regulator HrpL in Pseudomonas syringae
... ABSTRACT The type III secretion system (T3SS) is a principal virulence determi- nant of the model bacterial plant pathogen Pseudomonas syringae. T3SS effector proteins inhibit plant defense signaling ...
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Migration of Type III Secretion System Transcriptional Regulators Links Gene Expression to Secretion
... wild type or ΔhrpG, ΔhrpV, and ΔhrpJ knockout ...a secretion-incompetent ΔhrcC ...HrpA2 secretion (see ...of type III secretion), the accumulated HrpA2 may be exported via an ...
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Inflammasome Activation in Response to the Yersinia Type III Secretion System Requires Hyperinjection of Translocon Proteins YopB and YopD
... ABSTRACT Type III secretion systems (T3SS) translocate effector proteins into target cells in order to disrupt or modulate host cell signaling pathways and establish replicative ...
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The Ruler Protein EscP of the Enteropathogenic Escherichia coli Type III Secretion System Is Involved in Calcium Sensing and Secretion Hierarchy Regulation by Interacting with the Gatekeeper Protein SepL
... under T3S-inducing ...a secretion signal, but it is concealed by the sequence immediately after ...under T3S-inducing conditions and fractionated into periplasmic (P), cytoplasmic (C), IM, and OM ...
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