Type IV secretion system
Genetic variants of Helicobacter pylori type IV secretion system components CagL and CagI and their association with clinical outcomes
... translocate its major virulence protein cytotoxin associ- ated gene A (CagA) into host gastric epithelial cells using a type-IV secretion system (TFSS) [5, 6]. The role of the H. pylori TFSS ...
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Postreplication Roles of the Brucella VirB Type IV Secretion System Uncovered via Conditional Expression of the VirB11 ATPase
... VirB type IV secretion system (T4SS), a protein translocation apparatus essential for intracellular replication, modulation of host immune functions, and establishment of chronic brucellosis ...
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Higher glucose level can enhance the H. pylori adhesion and virulence related with type IV secretion system in AGS cells
... catenin signaling [24]. These results suggest a link between hyperglycemia, H. pylori and gastric cancer. High glucose could also increase endothelial permeability and altered basement membrane composition and structure ...
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Jimenez Soto, Luisa Fernanda (2009): Studies on the function of the Cag Type IV Secretion System of Helicobacter pylori with integrin Beta1. Dissertation, LMU München: Medizinische Fakultät
... TD), there was no competition between both of them. The fact that competition between the GST-fusion proteins and 9EG7 does not take place, indicates that the inhibition of CagA translocation by the 9EG7 antibody could ...
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Membrane and Core Periplasmic Agrobacterium tumefaciens Virulence Type IV Secretion System Components Localize to Multiple Sites around the Bacterial Perimeter during Lateral Attachment to Plant Cells
... IMPORTANCE Transfer of DNA and/or proteins to host cells through multiprotein type IV secretion system (T4SS) complexes that span the bacterial cell envelope is critical to bacterial ...
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Brucella abortus Infection of Placental Trophoblasts Triggers Endoplasmic Reticulum Stress Mediated Cell Death and Fetal Loss via Type IV Secretion System Dependent Activation of CHOP
... ABSTRACT Subversion of endoplasmic reticulum (ER) function is a feature shared by multiple intracellular bacteria and viruses, and in many cases this disruption of cellular function activates pathways of the unfolded ...
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Translocation through the Conjugative Type IV Secretion System requires unfolding of its protein substrate
... Relaxase constructs that block substrate translocation in the native plasmid. The experiments described above were conducted using an artificial two-plasmid system reporting on protein transport to the recipient ...
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In Situ Molecular Architecture of the Helicobacter pylori Cag Type IV Secretion System
... sequentially, by elaboration first of the Cag cylinder and then the outer spoked wheel. In step I, the three “core” subunits CagX, CagY, and CagM assemble as the Cag cylinder, a substructure sufficiently stable for ...
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Peptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens
... inhibit secretion of IL-8 and activa- tion of NF-B signaling in ...of type 1 pili or curli in ...IL-8 secretion and NF-B ac- tivation (C10 and KSK85 [Table 1]) in a dose-dependent manner ...IL-8 ...
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Molecular and Structural Analysis of the Helicobacter pylori cag Type IV Secretion System Core Complex
... Analysis of complexes formed by mutant strains.We hypoth- esized that several of the Cag proteins identified in the immuno- purification experiments would be required for assembly or sta- bility of the core complex, ...
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Structure of a translocation signal domain mediating conjugative transfer by Type IV secretion systems
... Relaxases are proteins responsible for the transfer of plasmid and chromosomal DNA from one bacterium to another during conjugation. They covalently react with a specific phosphodiester bond within DNA origin of transfer ...
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Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways
... genome shows genetic diversity among distinct isolates, and H. pylori pathogenicity is different in distinct iso- lates. Bacterial virulence factors exert an important influence in determining the clinical outcomes, and ...
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Unveiling Cell Surface and Type IV Secretion Proteins Responsible for Archaeal Rudivirus Entry
... tain two transmembrane helices, one at the N terminus and the other at the C terminus, while the sequence between them was presumed to be located intracellularly. Therefore, it appears that the proteins encoded in the ...
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Zhao, Qing (2017): Integrin-independent Helicobacter pylori CagA translocation via type IV secretion. Dissertation, LMU München: Medizinische Fakultät
... cag type IV secretion system ( cag -T4SS), a needle-like apparatus protruding from the bacterial surface, which is able to inject the effector protein CagA (cytotoxin- associated gene A) and ...
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Molecular detection of Bartonella henselae in 11 Ixodes ricinus ticks extracted from a single cat
... Bartonella adhesin A (BadA) mediates adhesion of Bartonella spp. to endothelial cells and the extracellular matrix proteins [24]. The VirB/VirD4 type IV secretion system (VirB) translocates ...
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Identification of a Novel Conjugative Plasmid in Mycobacteria That Requires Both Type IV and Type VII Secretion
... the type IV secretion ...novel type of conjugative plasmid that seems to be unique for ...three type IV secretion system components and a ...new type VII ...
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Overexpression of serine protease HtrA enhances disruption of adherens junctions, paracellular transmigration and type IV secretion of CagA by Helicobacter pylori
... HtrA secretion, cleavage of E-cadherin, bacterial transmigration and delivery of the type IV secretion system (T4SS) effector protein CagA into polarized epithelial cells, but did not ...
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Sensing of Bacterial Type IV Secretion via the Unfolded Protein Response
... immune system to differentiate be- tween friend and foe ...include type III and IV secretion systems (T3SS and T4SS, respectively) that translocate bacterial PAMPs such as flagellin, ...
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Structural organisation of the type IV secretion systems
... VirB11 and VirD4) and the VirB3, VirB6 and parts of the VirB8 and VirB10 proteins. The ATPases power system assembly and substrate translocation [17–21]. VirB3, VirB6, and VirB8 are likely to anchor VirB4 (and ...
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A Novel Mechanism for Protein Delivery by the Type 3 Secretion System for Extracellularly Secreted Proteins
... ABSTRACT The type 3 secretion system (T3SS) is essential for bacterial virulence through delivering effector proteins directly into the host cytosol. Here, we identi- fied an alternative delivery ...
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