Type IV secretion system (T4SS)
Postreplication Roles of the Brucella VirB Type IV Secretion System Uncovered via Conditional Expression of the VirB11 ATPase
... ABSTRACT Brucella abortus, the bacterial agent of the worldwide zoonosis brucellosis, primarily infects host phagocytes, where it undergoes an intracellular cycle within a dedicated membrane-bound vacuole, the ...
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Brucella abortus Infection of Placental Trophoblasts Triggers Endoplasmic Reticulum Stress Mediated Cell Death and Fetal Loss via Type IV Secretion System Dependent Activation of CHOP
... ABSTRACT Subversion of endoplasmic reticulum (ER) function is a feature shared by multiple intracellular bacteria and viruses, and in many cases this disruption of cellular function activates pathways of the unfolded ...
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Membrane and Core Periplasmic Agrobacterium tumefaciens Virulence Type IV Secretion System Components Localize to Multiple Sites around the Bacterial Perimeter during Lateral Attachment to Plant Cells
... IMPORTANCE Transfer of DNA and/or proteins to host cells through multiprotein type IV secretion system (T4SS) complexes that span the bacterial cell envelope is critical to bacterial ...
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Jimenez Soto, Luisa Fernanda (2009): Studies on the function of the Cag Type IV Secretion System of Helicobacter pylori with integrin Beta1. Dissertation, LMU München: Medizinische Fakultät
... The discovery of the association of Helicobacter pylori with gastric diseases 25 years ago opened a new view on the development of gastric disease and its relationship to microorganisms. With almost 50% of the human ...
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Genetic variants of Helicobacter pylori type IV secretion system components CagL and CagI and their association with clinical outcomes
... translocate its major virulence protein cytotoxin associ- ated gene A (CagA) into host gastric epithelial cells using a type-IV secretion system (TFSS) [5, 6]. The role of the H. pylori TFSS ...
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Higher glucose level can enhance the H. pylori adhesion and virulence related with type IV secretion system in AGS cells
... To establish H. pylori colonization and chronic inflam- mation at the gastric epithelium, adherence can serve as the first step of infection and then deliver effectors to induce inflammation [9-11]. The major adhesion, ...
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Translocation through the Conjugative Type IV Secretion System requires unfolding of its protein substrate
... Conclusion. Secretion in bacteria is a critical process in pathogenesis and interbac- terial competition in many bacterial ...specialized secretion systems to export a wide range of substrates, including ...
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In Situ Molecular Architecture of the Helicobacter pylori Cag Type IV Secretion System
... sequentially, by elaboration first of the Cag cylinder and then the outer spoked wheel. In step I, the three “core” subunits CagX, CagY, and CagM assemble as the Cag cylinder, a substructure sufficiently stable for ...
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Peptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens
... inhibit secretion of IL-8 and activa- tion of NF-B signaling in ...of type 1 pili or curli in ...IL-8 secretion and NF-B ac- tivation (C10 and KSK85 [Table 1]) in a dose-dependent manner ...IL-8 ...
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Molecular and Structural Analysis of the Helicobacter pylori cag Type IV Secretion System Core Complex
... these preparations contained a well-defined ring, but there was a marked reduction in peripheral content and no evidence of a well- organized outer ring (Fig. 4d). To further characterize the struc- tural features of ...
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Zhao, Qing (2017): Integrin-independent Helicobacter pylori CagA translocation via type IV secretion. Dissertation, LMU München: Medizinische Fakultät
... cag type IV secretion system ( cag -T4SS), a needle-like apparatus protruding from the bacterial surface, which is able to inject the effector protein CagA (cytotoxin- associated gene A) and ...
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Helicobacter pylori virulence factor CagA promotes tumorigenesis of gastric cancer via multiple signaling pathways
... T4SS: Type IV secretion system; PS: Phosphatidylserine; ERK: Extracellular signal-regulated kinase; MAPK: Mitogen-activated protein kinase; PI3K/ Akt: Phosphatidylinositol 3-kinase/Akt; NF- κ ...
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Overexpression of serine protease HtrA enhances disruption of adherens junctions, paracellular transmigration and type IV secretion of CagA by Helicobacter pylori
... HtrA secretion, cleavage of E-cadherin, bacterial transmigration and delivery of the type IV secretion system (T4SS) effector protein CagA into polarized epithelial cells, but did not ...
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Structure of a translocation signal domain mediating conjugative transfer by Type IV secretion systems
... T4S system or for the Dot/Icm T4S system from Legionella pneumophila are small clusters of positively charged or hydrophobic residues located at the C-terminus of the translocated substrates (Nagai et ...
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Type IV secretion in Gram negative and Gram positive bacteria
... the type VI secretion killing systems (Souza et ...this system was presented at a T4SS conference held last December 2016 in Schloss Hirschberg, Germany ...
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Unveiling Cell Surface and Type IV Secretion Proteins Responsible for Archaeal Rudivirus Entry
... tain two transmembrane helices, one at the N terminus and the other at the C terminus, while the sequence between them was presumed to be located intracellularly. Therefore, it appears that the proteins encoded in the ...
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Sensing of Bacterial Type IV Secretion via the Unfolded Protein Response
... immune system to differentiate be- tween friend and foe ...include type III and IV secretion systems (T3SS and T4SS, respectively) that translocate bacterial PAMPs such as flagellin, ...
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Structural Insight into How Bacteria Prevent Interference between Multiple Divergent Type IV Secretion Systems
... ABSTRACT Prokaryotes use type IV secretion systems (T4SSs) to translocate substrates (e.g., nucleoprotein, DNA, and protein) and/or elaborate surface structures (i.e., pili or adhesins). Bacterial ...
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Structure of a VirD4 coupling protein bound to a VirB type IV secretion machinery
... T4S system from Agrobacterium tumefa- ciens responsible for transfer of the T-DNA of the Ti plasmid into ...this system, T4S system components are termed VirB1- VirB11 and VirD4 (Fronzes et al, ...
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Molecular detection of Bartonella henselae in 11 Ixodes ricinus ticks extracted from a single cat
... Bartonella adhesin A (BadA) mediates adhesion of Bartonella spp. to endothelial cells and the extracellular matrix proteins [24]. The VirB/VirD4 type IV secretion system (VirB) translocates ...
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