Tyrosine kinases— are they required for Rd2?
Identification of Protein Tyrosine Kinases Required for B-Cell- Receptor-Mediated Activation of an Epstein-Barr Virus Immediate-Early Gene Promoter
... protein tyrosine kinases Syk and Btk and that it is positively reg- ulated by ...components required for BCR-dependent reactivation of latent EBV, and this system is likely to prove useful for ...
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Transglutaminases and receptor tyrosine kinases
... Fesus, L., and M. Piacentini (2002) Transglutaminase 2: an enigmatic enzyme with diverse functions. Trends in Biochemical Sciences 27:534-539. Goel, H.L., M. Breen, J. Zhang, I. Das, S. Aznavoorian-Cheshire, N.M. ...
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Receptor tyrosine kinases and their activation in melanoma
... is required for treatment of tumours with PTK inhibitors? It was initially expected that melanomas containing mutations within RAS or BRAF would be insensitive to inhibition of RTK ...
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Molecular imaging of receptor tyrosine kinases in cancer
... and tyrosine kinase inhibitors (TKIs) that target receptor tyrosine kinases (RTKs) and their ligands have been developed for cancer ...are required to maximize the chances for effective ...
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Light-inducible receptor tyrosine kinases that regulate neurotrophin signalling
... receptor tyrosine kinases (RTKs) 2 ...time required for diffusion, making it difficult or impossible to dissect and analyse the dynamic nature of cellular signalling networks in a spatiotemporally ...
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The role of Axl_Mertk_Tyro3 receptor tyrosine kinases in the clearance of apoptotic cells
... In summary, our report documents a novel role for Axl and Tyro3 receptors in the clearance of apoptotic cells and the combinatorial usage by macrophages and dendritic cells may provide clues for their biologic relevance. ...
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Abl family nonreceptor tyrosine kinases, which include Drosophila
... nonreceptor tyrosine kinases, which include Dro- sophila (D)-Abl and the mammalian Abl and Abl-related gene (Arg) proteins, are important regulators of cellular mor- phogenesis in developing metazoan ...
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Signaling by Non-Canonical Receptor Tyrosine Kinases ERBB3 and RYK
... 57 bumped inhibitors in cells, but the concentrations required to do so were sufficiently high that off-target effects are highly likely.) However, the lack of signaling response of analog sensitive ErbB3 to ...
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Abl Family Tyrosine Kinases Regulate Sialylated Ganglioside Receptors for Polyomavirus
... family tyrosine kinases are required for replication of mouse polyomavirus and BK virus, a human polyomavirus associated with allograft failure following kidney ...family kinases reduce ...
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Diverse Requirements for Src Family Tyrosine Kinases Distinguish Chlamydial Species
... Src-family kinases have been shown to phosphorylate tubulin and bind to dynein-associated proteins (36–38), suggesting that re- cruitment of Src-family kinases by chlamydiae may directly or indirectly ...
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Advances in mass spectrometry based strategies to study receptor tyrosine kinases.
... throughput required to generate the high-density phosphoprofiles that are necessary for understanding and targeting ...is required to contribute to ongoing efforts to develop personalized medi- cine in the ...
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Role of the ABL tyrosine kinases in the epithelial mesenchymal transition and the metastatic cascade
... ABL kinases function as a signaling nexus regulating cel- lular processes critical for the epithelial–mesenchymal transition and multiple subsequent steps in the metastatic ...ABL kinases are capable of ...
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Broad Spectrum Regulation of Nonreceptor Tyrosine Kinases by the Bacterial ADP Ribosyltransferase EspJ
... Our study showed that EspJ can also ADP-ribosylate Csk at the conserved catalytic glutamic acid, ablating its kinase activity. The EspJ homologues SeoC and SboC were also able to ADP-ribosylate Csk, suggesting that the ...
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Smad2 transduces common signals from receptor serine threonine and tyrosine kinases
... Results and Discussion Smad4 is structurally and functionally unique among the SMADs, acting as an essential component down- stream of TGF- b, activin, and BMP receptors (Lagna et al. 1996; de Caestecker et al. 1997; de ...
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A novel ligand-receptor relationship between families of ribonucleases and receptor tyrosine kinases
... of tyrosine kinase cascades [167, 168], the authors performed a human antibody array for phospho-RTKs and identified EGFR RTK as the dominant cell surface target activated by ...not required for EGFR ...
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Structure and molecular interaction analysis of monoclonal antibodies in complex with receptor tyrosine kinases
... Implications for the Mechanism of Inhibition of EGFR Activation by Matuzumab If matuzumab does not directly block access of the ligand to the domain III ligand-binding site, how does it prevent high-affinity ligand ...
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Community Environment Grant Application form Rd2
... a required field If your organisation is not incorporated, it is a requirement that you arrange for an incorporated organisation to sponsor your organisation's grant ...
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Polyomavirus middle-T antigen associates with the kinase domain of Src-related tyrosine kinases.
... are required for complex formation with middle-T (10) suggests that mid- dle-T may bind to a region close to the carboxy terminus of this ...Src-related kinases with a variety of proteins, it is conceivable ...
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An NMR study into the structure and interactions of the transmembrane domains of Neu and PDGFβ receptor tyrosine kinases
... 2007). Membrane proteins have traditionally presented themselves as very challenging sys- tems to study for structural biologists. This is primarily because they natively reside within the hydrophobic environment of the ...
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Tyrosine kinases in rheumatoid arthritis
... JAK tyrosine kinase activity directly through their kinase inhibitory region (KIR), which has been proposed to function as a pseu- dosubstrate and which is important for the suppression of cytokine ...
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