tyrosine phosphatase
Porphyromonas gingivalis Tyrosine Phosphatase Php1 Promotes Community Development and Pathogenicity
... of tyrosine phosphorylation in bacteria is mediated mainly by bacterial protein-tyrosine (BY) kinases in conjunction with three families of protein-tyrosine phosphatases: the low-molecular-weight ...
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Characterization of the catalytic properties of dual specificity protein tyrosine phosphatase hYVH1.
... strictly tyrosine-specific until Guan et a l, (1991) identified the first protein phosphatase encoded by the vaccinia virus (VH1) open reading frame that contains the signature motif of PTP superfamily, ...
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Pharmacological inhibition of protein tyrosine phosphatase 1B protects against atherosclerotic plaque formation in the LDLR −/− mouse model of atherosclerosis
... The exponential rise in patients presenting with obesity and type 2 diabetes has resulted an increased interest from pharmaceutical companies for the use of PTP1B inhibitors as a potential therapeutics [20]. Given there ...
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Regulation of the SNARE-interacting protein Munc18c tyrosine phosphorylation in adipocytes by protein-tyrosine phosphatase 1B
... Protein-tyrosine phosphatase 1B (PTP1B) is a ubiqui- tously expressed non-receptor tyrosine-specific phos- phatase that is localized on the cytoplasmic face of the endoplasmic reticulum (ER) ...this ...
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Protein tyrosine phosphatase-1B regulates the tyrosine phosphorylation of the adapter Grb2-associated binder 1 (Gab1) in the retina
... receptor tyrosine kinase is respon- sible for epithelial morphogenesis ...several tyrosine residues which, in turn, recruit a number of sig- naling effectors, including PI3K, SHP2, and ...protein ...
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Evidence that the protein tyrosine phosphatase (PC12,Br7,Sl) gamma ( ) isoform modulates chondrogenic patterning and growth
... In order to provide insight into this process, we have analyzed the developmental expressions of murine members of the tyrosine phosphatase family termed PTP(PC12,Br7,Sl), hence abbreviated as PTPPBS. ...
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Protein tyrosine phosphatase 1B restrains mammary alveologenesis and secretory differentiation
... specific tyrosine phosphatases in controlling mammary cell fate remains ill ...protein tyrosine phosphatase 1B (PTP1B) as an essential regulator of alveologenesis and ...
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Synthesis and Evaluation of Benzimidazole Derivatives as Protein Tyrosine Phosphatase (PTP1B) Inhibitors
... protein tyrosine kinase ...protein tyrosine phosphatases (PTP), which carry out the dephosphorylation of the ...Protein tyrosine Phosphatase 1B (PTP1B) is a negative regulator of insulin ...
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Skeletal muscle protein tyrosine phosphatase activity and tyrosine phosphatase 1B protein content are associated with insulin action and resistance
... protein tyrosine phosphatase (PTPase) activity was measured in skeletal muscle from 15 insulin-sensitive subjects and 5 insulin-resistant nondiabetic subjects, as well as 18 subjects with ...
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Inhibitory potential of polyhydroxylated fullerenes against protein tyrosine phosphatase 1B
... OH groups. More hydrophilic nanoparticles bind to active and allosteric sites with approximately equal binding energies. In contrast, the fullerene deriva tives with a lower degree of hydroxylation form more stable ...
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A novel role for protein tyrosine phosphatase 1B as a positive regulator of neuroinflammation
... protein tyrosine kinases and phosphatases. Protein tyrosine phosphatase 1B (PTP1B, also known as PTPN1) is a major negative regulator of the insulin and leptin signaling pathways ...insulin-induced ...
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Expression analysis and essential role of the putative tyrosine phosphatase His domain containing protein tyrosine phosphatase (HD PTP)
... protein tyrosine phosphatase called His-domain-contain- ing protein tyrosine phosphatase (HD-PTP) (Cao et ...protein tyrosine phosphatase domain (PTP) and a proteolytic ...
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<p>Prognostic Significance of Metastatic Lymph Nodes Ratio (MLNR) Combined with Protein-Tyrosine Phosphatase H1 (PTPH1) Expression in Operable Breast Invasive Ductal Carcinoma</p>
... Protein-tyrosine phosphatase H1 (PTPH1), also named PTPN3, is a 120-kDa protein that belongs to the non- transmembrane PTP ...EGFR tyrosine phosphorylation, thereby regulating the ER-EGFR interaction ...
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Druggability analysis and classification of protein tyrosine phosphatase active sites
... Abstract: Protein tyrosine phosphatases (PTP) play important roles in the pathogenesis of many diseases. The fact that no PTP inhibitors have reached the market so far has raised many questions about their ...
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Protein tyrosine phosphatase PTP-RR regulates corticosteroid sensitivity
... Protein tyrosine phosphatases (PTPs) which regulate the level of tyrosine phosphorylation play a critical role in regulating signaling molecules such as mitogen- activated protein kinases (MAPKs) ...16]. ...
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The Role Of Protein Tyrosine Phosphatase 1b In The Central Regulation Of Energy Homeostasis
... Furthermore, intracerebroventricular (ICV) but not intraperitoneal injection of IL-6 enhances energy expenditure in rats, and chronic ICV delivery over two weeks reduces food intake, body weight, and adiposity (Wallenius ...
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Molecular characterisation of CRYPα, an axonal receptor protein tyrosine phosphatase
... Receptor protein tyrosine phosphatases (RPTPs) represent a major research focus in developmental biology, oncology and immunology. Specifically, cell adhesion molecule-like RPTPs, including CRYPa, have recently ...
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NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22
... enhanced phosphatase activity (17), in vivo data indicated that the variant has effects similar to those of the knockout in terms of T cell regulation (25, 38, ...enhanced phosphatase activity and increased ...
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The prognostic significance of protein tyrosine phosphatase 4A2 in breast cancer
... The results are highly consistent between these five breast cancer data sets, showing that a low-level expression of PTP4A2 mRNA was associated with a shorter event-free survival time[r] ...
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Receptor protein tyrosine phosphatase signalling in development
... Src-family PTKs are not the only targets of RPTPalpha. For instance, also the insulin receptor is a candidate substrate of RPTPalpha (Møller et al., 1995). However, many other RPTPs may dephosphorylate the insulin ...
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