ubiquitin ligases
Regulation of SCF ubiquitin ligases by Jab1/Csn5 and the Cop9 signalosome
... SCF ubiquitin ligases participate in a wide array of regulatory processes, including cell cycle progression and signal ...the ubiquitin-like protein ...vitro ubiquitin ligase activity, we ...
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An essential role of CBL and CBL B ubiquitin ligases in mammary stem cell maintenance
... Members of the CBL family (CBL, CBL-B and CBL-C in mammals) of ubiquitin ligases serve as negative regulators of protein tyrosine kinases (PTKs), including RTKs and non-receptor PTKs (Mohapatra et al., ...
16
RavN is a member of a previously unrecognized group of Legionella pneumophila E3 ubiquitin ligases.
... modifier ubiquitin to cellular target proteins in order to alter their ...E3 ubiquitin ligases, eukaryotic enzymes that catalyze the final step in the ubiquitylation cas- ...E3 ligases to ...
26
E3 ubiquitin ligases and their control of T cell autoreactivity
... E3 ubiquitin ligases responsible for a ubiquitin-mediated counter-regulation of NF κ B in T ...Thus, ubiquitin-mediated degradation of these proteins represents a potentially important ...
10
Cell cycle and cell growth regulation by the CUL4-DDB1-ROC1 ubiquitin ligases
... hypothesis is that one of the CUL4-DDB1 ubiquitin ligases targets p53 for ubiquitination, probably through COP1 or one of DWD proteins. COP1 is composed of a RING finger domain and a WD40 repeat, and its ...
143
Screening analysis of ubiquitin ligases reveals G2E3 as a potential target for chemosensitizing cancer cells
... the ubiquitin system ...E3 ubiquitin ligase inhibitors, proteasome ...between ubiquitin ligases and substrates has been ...E3 ligases (three domains with similarity to both RING and PHD ...
16
The interplay between DSL proteins and ubiquitin ligases in Notch signaling
... Until now, it was thought that lateral inhibition in notum SOPs was solely mediated via Dl (Zeng et al., 1998) and that Dl transcriptional upregulation in the nascent neural precursor was crucial for a Dl-N negative ...
10
Control of Formin Distribution and Actin Cable Assembly by the E3 Ubiquitin Ligases Dma1 and Dma2
... E3 ubiquitin ligases that share 58% identity in their primary ...K63-linked ubiquitin chains (Loring et ...their ubiquitin ligase activity contribute to the overall organization of the actin ...
33
Signaling-mediated control of ubiquitin ligases in endocytosis
... distal ubiquitin at the growing end of the polyubiquitin chain on the substrate allows enzyme Figure ...E3 ubiquitin ligases through recruitment to activated ...
9
Following Ariadne's thread: a new perspective on RBR ubiquitin ligases
... E1 ubiquitin-activating enzyme, an E2 ubiquitin-conjugating enzyme, and an E3 ubiquitin ...E3 ubiquitin ligases assume the role of transferring activated ubiquitin from a ...
8
Cullin-RING ubiquitin ligases: global regulation and activation cycles
... Cullin-RING ubiquitin ligases (CRLs) comprise the largest known category of ubiquitin ligases. CRLs regulate an extensive number of dynamic cellular processes, including multiple aspects of ...
13
Glucose and Ras Activity Influence the Ubiquitin Ligases APC/C and SCF in Saccharomyces cerevisiae
... 22 mutants. Remarkably, cdc34-2 mutants, which are impaired in SCF function, are differently affected with respect to Ras activity. Viability of cdc34-2 mutants at elevated temperatures is dependent on glucose and the ...
13
The Molecular Basis of Substrate Recognition by the Family of Pellino E3 Ubiquitin Ligases
... E2 ubiquitin ligase-Pellino complex, the Pellino C-terminal RING domain would be stabilized by the interaction with the E2 ubiquitin ligase and protected from ...E2 ubiquitin ligases, UbcH7 ...
103
Regulation of cell fate determination by Skp1 Cullin1 F box (SCF) E3 ubiquitin ligases
... Several F-box proteins have key roles in major signaling pathways involved in patterning of the embryo, for instance - Transducin Repeat Containing Protein (-TRCP), which plays pleiotropic roles in regulation of cell ...
13
Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy
... The Casitas B-lineage Lymphoma (Cbl) family RING finger ubiquitin ligases (E3s) are recruited to a number of RTKs upon their activation and facilitate their turnover [11, 12]. Phosphorylated Cbl proteins ...
12
The Specificities of Kaposi's Sarcoma-Associated Herpesvirus-Encoded E3 Ubiquitin Ligases Are Determined by the Positions of Lysine or Cysteine Residues within the Intracytoplasmic Domains of Their Targets
... E3 ligases have evolved to target specific substrates not only through direct binding but also by limiting their ac- tivity to a specific subregion of the ...
6
The Cbl family of ubiquitin ligases regulates FcεRI expression and mast cell activation
... and ubiquitin ligases that limits the in- tensity and duration of positive signals, thus modu- lating mast cell ...cific ubiquitin modification of activated receptor subunits and associated protein ...
10
The crystal structure of the Sgt1 Skp1 complex: the link between Hsp90 and both SCF E3 ubiquitin ligases and kinetochores
... The essential cochaperone Sgt1 recruits Hsp90 chaperone activity to a range of cellular factors including SCF E3 ubiquitin ligases and the kinetochore in eukaryotes. In these pathways Sgt1 interacts with ...
14
The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions
... E3 ubiquitin ligase complexes play a central role in targeting cellular proteins for ubiquit- ination-dependent protein turnover through 26S ...E3 ubiquitin ligases were ...E3 ubiquitin ligase ...
11
Genetic and molecular characterization of Roc-Cullin interactions in Drosophila melanogaster E3 ubiquitin ligases
... E3 ubiquitin ligases (CDL) are key regulators of protein destruction that participate in a wide range of cell biological ...recruits ubiquitin charged E2 and is essential for ...
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