Ubiquitin-like protein
Interaction with a Ubiquitin-Like Protein Enhances the Ubiquitination and Degradation of Hepatitis C Virus RNA-Dependent RNA Polymerase
... NS5B protein by yeast two-hybrid screening of a human hepatocyte cDNA ...a ubiquitin-like protein, hPLIC1 (for human homolog 1 of protein linking intergrin-associated protein and ...
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Mycobacterium tuberculosis Proteasome Accessory Factor A (PafA) Can Transfer Prokaryotic Ubiquitin Like Protein (Pup) between Substrates
... The protein degradation machinery of Mycobacterium tuberculosis in- cludes a proteasome and a ubiquitin-like protein ...carrier protein transacylase (FabD) and lonely guy ...
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Ubiquitin-like protein FAT10 promotes bladder cancer progression by stabilizing survivin
... the ubiquitin-like protein (UBL) family, contains 165 amino acids consisting of two in-tandem ubiquitin-like domains ...FAT10 protein is expressed in many tumor cells, and high ...
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Ubiquitin-Like Protein 5 Positively Regulates Chaperone Gene Expression in the Mitochondrial Unfolded Protein Response
... a protein-handling ma- chinery that plays an essential role in mitochondrial bio- genesis and ...the protein- folding environment in the mitochondria might also contribute to sporadic diseases of aging (B ...
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Lin, Sean (2017): Role of the ubiquitin-like protein Urm1 as a protein modifier. Dissertation, LMU München: Fakultät für Biologie
... high identify to ThiS (20%) and MoaD (23%), particularly in the C-terminal region (Furukawa et al., 2000). ThiS, MoaD and the eukaryotic Urm1 are activated by adenylation at their C-terminal GG-motif by the ...
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Chemosensitivity is controlled by p63 modification with ubiquitin like protein ISG15
... the cytoplasm. To test this possibility, we determined the sub- cellular localization of ΔNp63α and its cleavage products using antibodies directed against the N- and C-terminal domains of ΔNp63α (referred to herein as ...
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Methionine Sulfoxide Reductase A (MsrA) and Its Function in Ubiquitin Like Protein Modification in Archaea
... ferritin-related protein), protein remodeling (thermosome Cct1/2, DnaK, Cdc48a/d, and peptidase S9), transcription (RpoB1), translation (AspS), DNA repair (Top6B), and metabolism (AldH2, PorB, AcaB4, and ...
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A Plastid Protein That Evolved from Ubiquitin and Is Required for Apicoplast Protein Import in Toxoplasma gondii
... of ubiquitin and ubiquitin-like proteins is the ability to bind to other proteins via a C-terminal glycine, and PUBL shares the requisite diglycine motif (38) (see ...conjugation-deficient ...
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The pupylation pathway and its role in mycobacteria
... Post-translational protein modification is a prevalent means of diversification and regulation in all cells ...effects like changes in protein conformation or stability, regulation of enzymatic ...
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FAT10: a Novel Mediator of Vpr-Induced Apoptosis in Human Immunodeficiency Virus-Associated Nephropathy
... the ubiquitin-like protein FAT10 as a critical mediator of Vpr-induced apoptosis in RTEC and define Vpr as the HIV-1 gene primarily respon- sible for FAT10 ...
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Small ubiquitin like modifier protein, SUMO enables plants to control growth independently of the phytohormone gibberellin
... action we incubated the immunoprecipitate with purified OTS1 SUMO protease as well as a catalytically inactive form of OTS1 (OTS1 C526S ). This treatment resulted in the dramatic reduction of the higher molecular weight, ...
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Reactivation of ubiquitination in Artemia franciscana embryos during recovery from anoxia induced quiescence
... of ubiquitin-mediated proteolysis on adenylates, the pathway is also known from in vitro work to be acutely pH-sensitive (Muller et ...of ubiquitin conjugates increased only slightly, revealing the ...
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Endosomal trafficking of yeast membrane proteins
... A large number of membrane trafficking mechanisms that control cargo sorting through the endosomal system have been elucidated in yeast. Classic genetic screens identified core machinery driving the secretory, endocytic, ...
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Progress in the Discovery of Small Molecule Modulators of DeSUMOylation
... responses, like the endoplasmic reticulum (ER) stress response, viral infections, nutrient response, and especially, the DNA damage response (Enserink, ...2015). Ubiquitin–SUMO crosstalk occurs extensively ...
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Gut Symbiont Bacteroides fragilis Secretes a Eukaryotic Like Ubiquitin Protein That Mediates Intraspecies Antagonism
... in its place have two genes encoding a toxin-antitoxin pair of the HigBA family (Fig. 4A, bottom). Eleven strains do not have any genes present in this region (Fig. 4A, middle). Each of the genomes encodes proteins with ...
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Characterization of the Interaction between the Parkin Ubiquitin-like domain and Ataxin-3 Ubiquitin Interacting Domains
... belonged to residues that were present in flexible regions, such as the C-terminal tail. There were a greater number of differences in resonance positions between the UbLD V15M 1 H- 15 N HSQC spectrum compared to that of ...
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Attachment of the Ubiquitin-Related Protein Urm1p to the Antioxidant Protein Ahp1p
... Although we have not identified which of the 14 lysines on Ahp1p is modified by Urm1p, two results support the idea that Ahp1p is a target and not an enzyme of the urmylation path- way. First, although the Ahp1p-Urm1p ...
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Ubiquitylation Regulates Cd4+ T Cell Activation and Effector Differentiation to Shape the Immune Response
... FoxP3 after TCR stimulation, supporting a role in Treg cell fate. Specifically, Stub1 is thought to amplify NF-κB signaling through ubiquitylation of CARD-containing MAGUK protein 1 (CARMA1), a critical component ...
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Discovery of a New Family of Protein Kinases Containing Phosphoinositide 3/4-Kinase and Ubiquitin-Like Domains
... unfolded protein response (UPR) in Arabidopsis thaliana. UbDKγ4 encodes a protein (Ser/Thr) kinase originally identified as a putative type II phosphatidylinositol ...controlled protein degradation ...
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Functional and phylogenetic analysis of the ubiquitylation system in Caenorhabditis elegans: ubiquitin conjugating enzymes, ubiquitin activating enzymes, and ubiquitin like proteins
... encode ubiquitin: ubq-1 encodes polyubiquitin [62], and ubq-2 encodes a fusion of ubiquitin and a ribosomal protein ...a ubiquitin-like and a ribosomal protein: ubl-1 ...separate ...
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