Ubiquitin-Proteasome Pathway
The Role of the Ubiquitin Proteasome Pathway in Papillomavirus Pathogenicity
... the ubiquitin proteasome pathway, consistent w ith the ability of RhPV-1 E7 to targ e t proteins for proteasom e-m ediated ...is ubiquitin ligase in order to targ et ...
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Genetic inhibition of the ubiquitin proteasome pathway : insights into proteasomal targeting
... the ubiquitin-proteasome pathway, E1 ubiquitin-activating enzyme, is encoded in Saccharomyces cerevisiae by the essential gene UBA1 (McGrath et ...all ubiquitin-mediated ...this ...
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The role of the ubiquitination proteasome pathway in breast cancer: Applying drugs that affect the ubiquitin proteasome pathway to the therapy of breast cancer
... the ubiquitin-proteasome pathway, such as PS-341, focus predominantly on the proteasome ...E1 ubiquitin-activating enzyme would have effects on normal and neoplastic cells that would, ...
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Regulation of Bovine Papillomavirus Replicative Helicase E1 by the Ubiquitin-Proteasome Pathway
... the ubiquitin-proteasome ...the proteasome, while it becomes resistant to this degradation pathway when bound to cyclin E/Cdk2 complexes before the start of DNA ...when proteasome ...
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The Ubiquitin-Proteasome Pathway Mediates Gelsolin Protein Downregulation in Pancreatic Cancer
... of ubiquitin-proteasome machinery toward gelsolin observed in the present study seems to provide an appealing explana- tion for the gelsolin ...the ubiquitin-proteasome pathway in the ...
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Pyrrolidine Dithiocarbamate Reduces Coxsackievirus B3 Replication through Inhibition of the Ubiquitin-Proteasome Pathway
... inhibited ubiquitin- proteasome-mediated proteolysis through direct inhibition of proteasome ...26S proteasome activities were measured using a synthetic fluorogenic sub- strate, ...known ...
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Inhibition of ubiquitin proteasome pathway–mediated IκBα degradation by a naturally occurring antibacterial peptide
... 26S proteasome and blocks degradation of NF-κB inhibitor IκBα by the ubiquitin-proteasome pathway without affecting overall proteasome ...
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Heat Shock Protein 70 Regulates Degradation of the Mumps Virus Phosphoprotein via the Ubiquitin-Proteasome Pathway
... the ubiquitin-proteasome ...in ubiquitin-mediated degradation of the P and V proteins, the effects of Hsp72 knockdown were ...cific proteasome inhibitors, lactacystin and epoxomycin, which ...
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Kaposi's Sarcoma-Associated Herpesvirus RTA Promotes Degradation of the Hey1 Repressor Protein through the Ubiquitin Proteasome Pathway
... Received 17 February 2009/Accepted 2 April 2009 The Kaposi’s sarcoma-associated herpesvirus (KSHV) replication and transcription activator (RTA) protein regulates the latent-lytic switch by transactivating a variety of ...
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The N-Terminal Region of Nurr1 (a.a 1 31) Is Essential for Its Efficient Degradation by the Ubiquitin Proteasome Pathway
... the ubiquitin-proteasome pathway, as it is inhibited by specific proteasome inhibitors and polyubiqui- tylated at its subcellular nuclear ...lysosomal pathway of degradation does not ...
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Analysis of the Protein Kinase A Regulated Proteome of Cryptococcus neoformans Identifies a Role for the Ubiquitin Proteasome Pathway in Capsule Formation
... the proteasome, metabolism, amino acid biosynthesis, and virulence-related ...the ubiquitin-proteasome pathway in ...of proteasome function with the inhibitor bortezomib revealed an ...
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Paeoniflorin inhibits glioblastoma growth in vivo and in vitro: a role for the Triad3A-dependent ubiquitin proteasome pathway in TLR4 degradation
... and ubiquitin–pro- teasome ...autophagy–lysosome pathway or the ubiquitin–proteasome pathway by analyzing TLR4 protein expression levels in cultured cells treated with paeoniflorin in ...
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Induction of protein catabolism in myotubes by 15(S)-hydroxyeicosatetraenoic acid through increased expression of the ubiquitin proteasome pathway
... C3 proteasome subunit expression by opposing this suppressor ...the ubiquitin – proteasome pathway induced by ...the ubiquitin – proteasome ...increased proteasome ...
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Function of the ubiquitin proteasome pathway in auxin response
... SCF ubiquitin ligases 20 ...mediate ubiquitin-ligase ...the ubiquitin-conjugating enzyme Cdc34p ...conjugation pathway confer no obvious phenotype, a synthetic lethal phenotype is observed ...
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The effect of temperature adaptation on the ubiquitin–proteasome pathway in notothenioid fishes
... Fields and Houseman, 2004; Galarza-Muñox et al., 2011). To offset the effects of low temperature on reaction rates, we would predict some degree of thermal compensation of the activity of the 26S proteasome in ...
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Deubiquitination : does the answer to cardiotoxicity lie within the ubiquitin proteasome pathway
... 4.6 USP36 down-regulation improves mitochondrial anti-oxidant expression post chronic DOX treatment This study showed that chronic DOX treatment did not induce any changes in USP36 expression. We were also able to show ...
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Chemical approaches to targeted protein degradation through modulation of the ubiquitin proteasome pathway
... the proteasome inhibitor epoxomicin, resulting in blockade of the degradation of ERRα and ...compensatory pathway that produces leukemic stem cells in spite of kinase ...
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Moloney leukemia virus 10 (MOV10) inhibits the degradation of APOBEC3G through interference with the Vif mediated ubiquitin–proteasome pathway
... To further confirm this, the A3G levels were analyzed in virus-producing cells and viral particles following depletion of endogenous MOV10 with MOV10-specific siRNAs. MOV10 knockdown could reduce the quantity of A3G in ...
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Fucoidan inhibition of lung cancer in vivo and in vitro : role of the Smurf2-dependent ubiquitin proteasome pathway in TGFβ receptor degradation
... by ubiquitin-mediated targeting [28] and proteasomal degradation ...the ubiquitin proteasome-mediated pathway in TGFR degradation is correlated with Smurf2/Smad7 activity, indicating that ...
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Sepsis is associated with increased mRNAs of the ubiquitin proteasome proteolytic pathway in human skeletal muscle
... for ubiquitin and the 20 S proteasome subunit HC3 by Northern blot analysis in muscle tissue from septic (n = 7) and non-septic (n = 11) ...for ubiquitin and HC3 was noted in muscle tissue from the ...
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