ubiquitin-proteasome system (UPS)
The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma
... The proteasome inhibitor bortezomib, approved by the FDA for treatment of multiple myeloma and mantle cell lymphoma, has been used in preclinical studies to inhibit CNS tumor growth ...the proteasome ...
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Emerging therapies targeting the ubiquitin proteasome system in cancer
... The ubiquitin proteasome system. The ubiquitin proteasome system (UPS) is an elaborate and highly regulated cellular system that mediates selective protein ...
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The Ubiquitin-Proteasome System Is Necessary for Efficient Replication of Human Astrovirus
... The ubiquitin-proteasome system (UPS) is the major degradation system in the ...this system consist of the degradation of misfolded/damaged proteins (12, 13) and the regulation ...
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The ubiquitin proteasome system is required for cell proliferation of the lens epithelium and for differentiation of lens fiber cells in zebrafish
... The ubiquitin proteasome system (UPS) is important for the removal of unnecessary proteins and regulates normal cellular functions through the degradation of a variety of regulatory proteins ...
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Ubiquitin proteasome system dysfunction in experimental models of Parkinson's disease
... and ubiquitin proteasome system (UPS) impairment (Uch-L1, Parkin and α-synuclein) as key events associated with PD (Moore et ...of UPS dysfunction in the pathogenesis of PD is also ...
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The interaction of hepatitis B virus with the ubiquitin proteasome system in viral replication and associated pathogenesis
... host ubiquitin proteasome system (UPS) has vital roles in HBV replication as well as virus-related ...the UPS is mediating the degradation of cellular ...protein ubiquitin (Ub) ...
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Orthopoxviruses Require a Functional Ubiquitin-Proteasome System for Productive Replication
... cellular system known to have a role in poxvirus infection is the ubiquitin-proteasome ...The ubiquitin- proteasome system tightly regulates important cellular func- tions, such ...
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Replication of the Rotavirus Genome Requires an Active Ubiquitin-Proteasome System
... the ubiquitin-proteasome system is required for the efficient replication of rotavirus RRV in MA104 ...The proteasome inhibitor MG132 decreased the yield of infectious virus under conditions ...
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The Ubiquitin–Proteasome System of Saccharomyces cerevisiae
... several ubiquitin-like pro- teins (UBLs), each with a dedicated conjugation machinery: Smt3 (this modification is known as SUMOylation), Rub1 (NEDDylation), Urm1 (urmylation), and the autophagy fac- tors Atg8 and ...
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The ubiquitin-proteasome system in glioma cell cycle control
... Last but not least, the induction of G0/G1 or G2/M cell cycle arrest and/or apoptosis, whenever indicated as a response to various stressors, could not be ensured without the critical involvement of p53, whose levels and ...
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Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy
... the UPS (Figure ...the UPS being one possible ...the UPS, and autophagy ...to proteasome inhibitors [13], and some yeast cells that adapted to aneuploidy were found to contain muta- tions that ...
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Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease
... the UPS. The main function of the UPS is to degrade unneeded or damaged proteins, but the proteasome machinery is, as is CYLD, also a key regulator of the NF- κ B ...the UPS to induce an in fl ...
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Interplay between the Ubiquitin Proteasome System and Mitochondria for Protein Homeostasis
... the UPS substrates, which are ear-marked by ubiq- uitin, the autophagosome membrane is ear-marked by the small ubiquitin-like modifier Atg8 (LC3 in ...
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The possible role of the ubiquitin proteasome system in the development of atherosclerosis in diabetes
... proteolytic system in reticulocytes that had been previously described by Etlinger [11] in ...the proteasome [12]. The UPS is responsible for the non-lysosomal degra- dation of the majority of ...
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Rhabdoviruses and the Cellular Ubiquitin-Proteasome System: a Budding Interaction
... VSV-infected cells were incubated with proteasome inhibi- tors for no more than 2.5 h since prolonged exposure to these inhibitors can lead to a complete shutdown of protein synthe- sis. To demonstrate that total ...
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Equine Infectious Anemia Virus and the Ubiquitin-Proteasome System
... of proteasome treatment was determined by observing the status of Ub inside the cells during the time course experiments presented above using our monoclonal an- tibody (the same 2C5 clones used previously) that ...
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Sit4 Phosphatase Is Functionally Linked to the Ubiquitin-Proteasome System
... by proteasome-mediated Interestingly, although sit4-51 and sit4-102 cells showed protein destruction? Such a model is supported by the similar effects with defects of the ubiquitin-proteasome clear ...
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HDAC4 preserves skeletal muscle structure following long-term denervation by mediating distinct cellular responses
... the UPS and autophagy. Indeed, if UPS or autophagic hyper-activation leads to muscle atrophy [54, 55], their impairment in conditions in which they must be activated is deleterious for skeletal muscle [56, ...
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Expression profile of a Caenorhabditis elegans model of adult neuronal ceroid lipofuscinosis reveals down regulation of ubiquitin E3 ligase components
... to man, elucidation of the mechanisms and regulators of CSP-dependent pathways in worms may illu- minate general aspects of normal neuroprotective pathways that could be targeted in the treatment of neurodegenerative ...
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Post-translational modification of Parkin and its research progress in cancer
... UBL: ubiquitin‑like domain; UPS: ubiquitin–proteasome system; SP22: 22‑kilodal‑ ton glycosylated form of α‑synuclein; PINK1: PTEN‑induced kinase 1; p‑Ub: phospho‑ubiquitination; BNIP3: ...
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