Ubiquitin specific protease
Prevalence of Plasmodium falciparum delayed clearance associated polymorphisms in adaptor protein complex 2 mu subunit (pfap2mu) and ubiquitin specific protease 1 (pfubp1) genes in Ghanaian isolates
... falciparum ubiquitin specific protease 1 gene; SEA: Southeast Asia; SNPs: single nucleotide polymorphisms; SYN: synonymous mutations; WHO: World Health ...
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Original Article Ubiquitin-specific protease 22 as a prognostic biomarker in patients with various cancers: a meta-analysis
... Abstract: Many studies have reported that elevated ubiquitin-specific protease 22 (USP22) expression was associa- tion with poor prognosis in various cancer patients. To evaluate the prognostic value ...
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Prognostic and clinicopathological significance of ubiquitin-specific protease 22 overexpression in cancers: evidence from a meta-analysis
... 30. Yang DD, Cui BB, Sun LY, et al. The co-expression of USP22 and BMI-1 may promote cancer progression and predict therapy failure in gastric carcinoma. Cell Biochem Biophys. 2011;61(3):703–710. 31. Liang JX, Ning Z, ...
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Herpes Simplex Virus 1 Ubiquitin-Specific Protease UL36 Inhibits Beta Interferon Production by Deubiquitinating TRAF3
... UL36 ubiquitin-specific protease), which is embedded within the N-terminal region of HSV-1 VP1/2 ...highly specific for ubiquitin and cleaves K48- and K63-linked polyubiquitin chains ...
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Targeting ubiquitin-specific protease 22 suppresses growth and metastasis of anaplastic thyroid carcinoma
... B-cell- specific murine leukemia virus integration site-1; cl- caspase-3, cleaved caspase-3; DAB, diaminobenzidine; DAPI, 4ʹ, 6-diamidino-2-phenylindole; EdU, 5-ethynyl- 2ʹ-deoxyuridine; EMT, epithelial- ...
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Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction
... Background: Ubiquitin-specific protease 14 (USP14) is one of three proteasome-associated deubiquitinating enzymes that remove ubiquitin from proteasomal substrates prior to their ...
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Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer
... (DUB), ubiquitin specific protease 12 (Usp12) as a positive regulator of the AR responsible for deubiquitinating and subsequently stabilising the ...
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Mutagenesis of the Active-Site Cysteine in the Ubiquitin-Specific Protease Contained in Large Tegument Protein pUL36 of Pseudorabies Virus Impairs Viral Replication In Vitro and Neuroinvasion In Vivo
... Herpesviruses specify a ubiquitin-specific protease activity located within their largest tegument protein. Although its biological role is still largely unclear, mutation within the active site ...
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Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer
... (DUB), ubiquitin specific protease 12 (Usp12) as a positive regulator of the AR responsible for deubiquitinating and subsequently stabilising the ...
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The Ubiquitin-Specific Protease USP7 Modulates the Replication of Kaposi's Sarcoma-Associated Herpesvirus Latent Episomal DNA
... Kaposi’s sarcoma herpesvirus (KSHV) belongs to the gamma-2 Herpesviridae and is associated with three neoplastic disorders: Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman’s disease ...
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Reciprocal Activities between Herpes Simplex Virus Type 1 Regulatory Protein ICP0, a Ubiquitin E3 Ligase, and Ubiquitin-Specific Protease USP7
... E3 ubiquitin ligases whose levels are regulated at least in part by ...E3 ubiquitin ligase pro- teins by ubiquitin-specific protease enzymes has also been im- plicated in the ...
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Assess the expression of ubiquitin specific protease USP2a for bladder cancer diagnosis
... USP2a: Ubiquitin-specific protease 2a; FASN: Fatty acid synthase; OSCC: Oral squamous cell carcinoma; AJCC: American Joint Committee on Cancer; UHRF1: E3 ubiquitin-protein ligase UHRF1; PFKB: ...
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Negative regulation of NF-κB signaling in T lymphocytes by the ubiquitin-specific protease USP34
... IKKβ) and a regulatory subunit (NEMO, also called IKKγ) [8]. IKK phosphorylation of IκBs precipitates their K48-linked ubiquitinylation and proteasomal elimination, and thereby allows NF-κB to translocate to the nucleus ...
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Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A
... that ubiquitin specific protease 19 (USP19) as a DUB is gradually decreased during adipogenesis and it regulates coronin 2A (CORO2A) as one of the components for the nuclear receptor co-repressor ...
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Tsg101 Interacts with Herpes Simplex Virus 1 VP1/2 and Is a Substrate of VP1/2 Ubiquitin-Specific Protease Domain Activity
... tegument ubiquitin-specific protease (htUSP) ...recruit specific cellular factors, Tsg101, Nedd4-like ubiquitin ligases, and AIP1, respectively ...of specific proteins during ...
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Ubiquitin-specific protease 7 expression is a prognostic factor in epithelial ovarian cancer and correlates with lymph node metastasis
... Total cell extracts were prepared with NP-40 Buffer (50 mM Tris–HCl pH 7.5, 150 mM NaCl, 1% NP-40, 0.5% sodium deoxycholate) and protease inhibitor cocktails (1:1,000). Approximately 40 μ g of each protein sample ...
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Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer
... The ubiquitin-proteasome pathway is an important intracellular protein degradation regulatory system ...The ubiquitin-specific proteases (USPs) are the largest subclass of DUBs ...moving ...
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Ubiquitin-specific protease 11 functions as a tumor suppressor by modulating Mgl-1 protein to regulate cancer cell growth
... generated ubiquitin mutants that Lys was substituted with Arg (Figure 2D) ...of ubiquitin R48K chains with Mgl-1, we could detect USP11 deubiquitinating activity for Mgl-1 (Figure ...R63K ubiquitin ...
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Herpes Simplex Virus 1 Ubiquitin-Specific Protease UL36 Abrogates NF-κB Activation in DNA Sensing Signal Pathway
... Herpes simplex virus 1 (HSV-1) belongs to the alphaherpesvirus subfamily, is a large dsDNA virus with a genome of about 152 kb, and encodes over 80 open reading frames (21, 22). As the largest tegument protein encoded by ...
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A Functional Ubiquitin-Specific Protease Embedded in the Large Tegument Protein (ORF64) of Murine Gammaherpesvirus 68 Is Active during the Course of Infection
... DUB expression in MHV-68-infected fibroblasts. We began our investigations by infecting mouse fibroblasts with MHV-68. At various times after infection, cell lysates were prepared, which were incubated for 30 min at room ...
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