Ubiquitin Specific Protease 14
Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction
... Background: Ubiquitin-specific protease 14 (USP14) is one of three proteasome-associated deubiquitinating enzymes that remove ubiquitin from proteasomal substrates prior to their ...
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Structure and catalytic regulatory function of ubiquitin specific protease 11 N terminal and ubiquitin like domains
... First, 14 conserved residues including a VEVY motif locate to the interface formed between the linker region and the DUSP domain, highlighting the importance of this interface as a key feature of the DU domain ...
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Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer
... SUZ12 (Suppressor of zeste 12 protein homolog) is a core component of the Polycomb PRC2-HMTase complex, which has been shown to be involved in stem cell mainten- ance and development [11, 12]. SUZ12 is upregulated in ...
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Autocatalytic Activity of the Ubiquitin-Specific Protease Domain of Herpes Simplex Virus 1 VP1-2
... 11, 14, 25, 26, 28, 34), the precise mechanistic role of the USP activity within VP1-2 remains poorly under- ...its ubiquitin cleavage ac- tivity in vitro, and while the corresponding mutation in the ...
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Tsg101 Interacts with Herpes Simplex Virus 1 VP1/2 and Is a Substrate of VP1/2 Ubiquitin-Specific Protease Domain Activity
... tegument ubiquitin-specific protease (htUSP) ...recruit specific cellular factors, Tsg101, Nedd4-like ubiquitin ligases, and AIP1, respectively ...of specific proteins during ...
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Negative regulation of NF-κB signaling in T lymphocytes by the ubiquitin-specific protease USP34
... In addition to NF-κB, TCR ligation kindles various signal- ing pathways including Nuclear factor of activated T-cells (NFAT) and the Mitogen-activated protein kinase (MAPK) Extracellular signal-regulated kinases (ERK) ...
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Targeting ubiquitin-specific protease 22 suppresses growth and metastasis of anaplastic thyroid carcinoma
... It was first identified as one of the cohort of genes that predict the recurrence, metastasis, and/or therapeutic responses of various types of cancers, known as the “death-from-cancer” signature. USP22 overexpression is ...
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Prevalence of Plasmodium falciparum delayed clearance associated polymorphisms in adaptor protein complex 2 mu subunit (pfap2mu) and ubiquitin specific protease 1 (pfubp1) genes in Ghanaian isolates
... The use of ACTs in Ghana began in 2005 and since then the cure rate of the drugs in use, artesunate-amodiaquine (AS-AQ) and artemether-lumifantrine (AL), has been 100 and 97.6%, respectively, as of 2014 [12]. ...
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A Gammaherpesvirus Ubiquitin-Specific Protease Is Involved in the Establishment of Murine Gammaherpesvirus 68 Infection
... deubiquitinating protease (14), based on an activ- ity-based profiling approach that takes advantage of a ubiq- uitin-based active site-directed probe, UbVME, to target USPs (6, ...
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Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance
... involved in host-virus interaction, DNA damage and repair, gene expression and protein function regula- tion, immunization and others cellular process [8]. USP7 plays a multifaceted role and is involved in the develop- ...
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Assess the expression of ubiquitin specific protease USP2a for bladder cancer diagnosis
... following primers were used to determine USP2a mRNA levels: forward 5′-TGCTGAGACCCGACATCACT-3′; re- verse 5′-TGGGGTCTATCCGGTAGCTA-3′, as described in previous literature [12]. The PCR reaction was per- formed in a final ...
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Reciprocal Activities between Herpes Simplex Virus Type 1 Regulatory Protein ICP0, a Ubiquitin E3 Ligase, and Ubiquitin-Specific Protease USP7
... This paper demonstrates that USP7 can be regulated through ubiquitination and proteasome-mediated degradation during HSV-1 infection. Therefore, in addition to being sub- ject to proteolytic cleavage in response to ...
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Prognostic and clinicopathological significance of ubiquitin-specific protease 22 overexpression in cancers: evidence from a meta-analysis
... Seven of the studies were of patients with digestive system cancers (colorectal cancer, hepatocellular cancer, esophageal cancer, gastric cancer, and pancreatic cancer), 16,18,23,28–31[r] ...
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The Ubiquitin-Specific Protease USP7 Modulates the Replication of Kaposi's Sarcoma-Associated Herpesvirus Latent Episomal DNA
... Kaposi’s sarcoma herpesvirus (KSHV) belongs to the gamma-2 Herpesviridae and is associated with three neoplastic disorders: Kaposi’s sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman’s disease ...
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Ubiquitin-specific protease 7 expression is a prognostic factor in epithelial ovarian cancer and correlates with lymph node metastasis
... Total cell extracts were prepared with NP-40 Buffer (50 mM Tris–HCl pH 7.5, 150 mM NaCl, 1% NP-40, 0.5% sodium deoxycholate) and protease inhibitor cocktails (1:1,000). Approximately 40 μ g of each protein sample ...
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Overview of the organization of protease genes in the genome of Leishmania spp
... of protease genes in four species, a method- ology we applied to identify species-specific features that may account for phenotypic or virulence differences among the studied ...of protease genes ...
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Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A
... that ubiquitin specific protease 19 (USP19) as a DUB is gradually decreased during adipogenesis and it regulates coronin 2A (CORO2A) as one of the components for the nuclear receptor co-repressor ...
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SUMO specific proteases/isopeptidases: SENPs and beyond
... SUMO-targeted ubiquitin-ligases ...SUMO2/3-binding ubiquitin ligases that are recruited to poly-SUMOylated substrates to trigger their ...under specific conditions is currently not ...
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Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer
... Recently, ML323 and its derivatives were identified as more potent and specific Usp1/Uaf-1 inhibitors. Authors suggested that ML323 specificity was achieved by targeting the DUB complex as opposed to the Usp1 ...
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The Yeast Ubiquitin Protease, Ubp3p, Promotes Protein Stability
... We considered two possible explanations for the stu1-5 An overlap in function between these two enzymes was ubp3⌬ synthetic lethality. First, we examined the possibil- previously suggested because loss of Doa4p or Ubp6p ...
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