ubiquitin-specific protease 2
Prevalence of Plasmodium falciparum delayed clearance associated polymorphisms in adaptor protein complex 2 mu subunit (pfap2mu) and ubiquitin specific protease 1 (pfubp1) genes in Ghanaian isolates
... Malaria is still a debilitating disease, especially in sub- Saharan Africa (sSA) where there were 212 million cases and 429,000 malaria-related deaths in 2015 [1]. There has been a 21 and 29% reduction in morbidity and ...
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Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A
... detach ubiquitin molecules from ubiquitinated substrates, changing the fate of these substrates, including their activity or ...classes, ubiquitin specific proteases (USPs), ubiquitin ...
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The Ubiquitin-Specific Protease USP7 Modulates the Replication of Kaposi's Sarcoma-Associated Herpesvirus Latent Episomal DNA
... USP7 does not influence the transactivation function of LANA. LANA acts as a transcriptional repressor or activator of several cellular and viral genes. Therefore, we analyzed the possi- ble influence of USP7 binding on ...
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Reciprocal Activities between Herpes Simplex Virus Type 1 Regulatory Protein ICP0, a Ubiquitin E3 Ligase, and Ubiquitin-Specific Protease USP7
... of 2 PFU per ...of 2 PFU per ...of 2 PFU/cell) and then samples taken at the indicated time points were analyzed for PML and ICP0 by Western ...
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Ubiquitin-specific protease 7 expression is a prognostic factor in epithelial ovarian cancer and correlates with lymph node metastasis
... Survival information of 141 patients with EOC was obtained through letters and phone calls. The 5-year OS of the total patients was 62.34%, and the median sur- vival time was 78 months. The Kaplan–Meier univariate ...
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Prognostic and clinicopathological significance of ubiquitin-specific protease 22 overexpression in cancers: evidence from a meta-analysis
... tissues; 2) evaluating the association between USP22 expression and cancer prognosis; and 3) providing sufficient information to estimate hazard ratios (HRs) with 95% confidence intervals ...and 2) ...
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Negative regulation of NF-κB signaling in T lymphocytes by the ubiquitin-specific protease USP34
... Figure 2 Knockdown of USP34 selectively potentiates NF- κ B activation. (A) NFAT reporter luciferase assay (mean ± S.D. of triplicate experiments) of Jurkat cells transfected with control non-targeting (n.t.) or ...
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Targeting ubiquitin-specific protease 22 suppresses growth and metastasis of anaplastic thyroid carcinoma
... Human ATC cell lines CAL-62 and 8505C were purchased from Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSMZ), which certifies the origin and identity of the cells. The benign human thyroid follicular cell ...
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Ubiquitin specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis
... Since a series of hierarchically organized protein phosphor- ylation events is the principal feature that fuels the genome surveillance in the DDR (35), we hypothesized that a damage- induced increase in the binding ...
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<p>Ubiquitin-specific protease 4 promotes glioblastoma multiforme via activating ERK pathway</p>
... shUSP4-1: 5 ′ -GCGTGGAATAAACTACTAA-3 ′ ; shUSP4-2: 5 ′ -CCTTTCTTCTAGATGGATT-3 ′ ; shUSP4-3: 5 ′ -GGTGGTCGCAGATGTGTAT-3 ′ ; shUSP4-4: 5 ′ -GCTGAACATGTCCGAGTTT-3 ′ . Cells were seeded into 6-well plates and cultured ...
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Herpes Simplex Virus 1 Ubiquitin-Specific Protease UL36 Inhibits Beta Interferon Production by Deubiquitinating TRAF3
... removing polyubiquitin chain on TRAf3, and C40A HSV-1 infec- tion failed to deubiquitinate TRAF3, inducing more IFN- and ISGs expression than WT virus did. HSV-1 evolves multiple im- mune evasion strategies, and several ...
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Ubiquitin-specific protease 11 functions as a tumor suppressor by modulating Mgl-1 protein to regulate cancer cell growth
... cDNA for USP11, RT-PCR was performed with reference to cDNA coding sequence of mouse USP11 in GenBank (NM_145628). RNA isolated from NIH3T3 cells served as templates for reverse transcription. The amplified DNA fragment ...
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Ubiquitin-specific protease 22 is critical to in vivo angiogenesis, growth and metastasis of non-small cell lung cancer
... identified that angiogenesis, cell cycle progression, epithelial- mesenchymal transition (EMT), KRAS, and c-Myc signaling pathways were significantly downregulated in the USP22−/− cancer cells (Fig. 2b). In contrast, ...
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Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer
... with 2 mM L-glutamine (Invitrogen) supplemented with 10% (v/v) foetal calf serum at 37°C in 5% CO 2 ...RPMI-1640, 2 mM L-glutamine and 10% charcoal treated foetal calf serum, denoted steroid depleted ...
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Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer
... with 2 mM L-glutamine (Invitrogen) supplemented with 10% (v/v) foetal calf serum at 37°C in 5% CO 2 ...RPMI-1640, 2 mM L-glutamine and 10% charcoal treated foetal calf serum, denoted steroid depleted ...
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Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction
... Figure 7 Inhibition of pJNK improves the structural and functional deficits caused by inhibition of USP14 ’ s DUB activity. (A) Representative immunoblots of pJNK1/2 and JNK1/2 in spinal cords from ...
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Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer
... Several studies have shown that phosphorylation level proteins which involved ERKl/2/Akt signaling has emerged as a central feature of EMT, which is the initial step for metastasis in many cancer models [19, 22]. ...
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Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance
... The paraffin-embedded tissues sections from 100 matched pairs of liver adenocarcinoma and nonmalig- nant liver tissue of the same patients. The tissues were heated at 60 °C for 45 min and deparaffinized using a graded ...
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Autocatalytic Activity of the Ubiquitin-Specific Protease Domain of Herpes Simplex Virus 1 VP1-2
... which would target for degradation but which was actively counteracted by deubiquitination involving the functional USP itself. In the absence of USP activity (i.e., C65A mutation), the protein was efficiently ...
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Structure and catalytic regulatory function of ubiquitin specific protease 11 N terminal and ubiquitin like domains
... investigated the oligomerization state of full-length hUSP11 using gel fi ltration which showed that full-length hUSP11 is monomeric in solution (Figure S3G, Supporting Information). In fl uence of the USP11 DUSP-UBL and ...
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