Ubiquitin-specific protease 22
Original Article Ubiquitin-specific protease 22 as a prognostic biomarker in patients with various cancers: a meta-analysis
... Abstract: Many studies have reported that elevated ubiquitin-specific protease 22 (USP22) expression was associa- tion with poor prognosis in various cancer patients. To evaluate the ...
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Targeting ubiquitin-specific protease 22 suppresses growth and metastasis of anaplastic thyroid carcinoma
... Increasing evidences showed that USP22 serves a critical function in numerous pathological progresses and may be used as a highly promising diagnostic and/ or prognostic marker of cancers [13, 17]. In this study, we ...
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Prognostic and clinicopathological significance of ubiquitin-specific protease 22 overexpression in cancers: evidence from a meta-analysis
... Seven of the studies were of patients with digestive system cancers (colorectal cancer, hepatocellular cancer, esophageal cancer, gastric cancer, and pancreatic cancer), 16,18,23,28–31[r] ...
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Ubiquitin-specific protease 22 is critical to in vivo angiogenesis, growth and metastasis of non-small cell lung cancer
... peptidase 22 (USP22), a subunit of the human SAGA (Spt-Ada-Gcn5-Acetyltransferase) complex, is an ubiquitin hydrolase, catalyzing the removal of the mono- ubiquitin moiety from histone H2B (H2Bub1) ...
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Mutagenesis of the Active-Site Cysteine in the Ubiquitin-Specific Protease Contained in Large Tegument Protein pUL36 of Pseudorabies Virus Impairs Viral Replication In Vitro and Neuroinvasion In Vivo
... ⌬ 22–248 [7]) we observed a reduction in viral titers which was similar to that of PrV-UL36(C 26 S), which parallels data from work by others ...⌬ 22–248 were reduced only to 82% of original size and mean ...
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Negative regulation of NF-κB signaling in T lymphocytes by the ubiquitin-specific protease USP34
... the ubiquitin-dependent IKKβ kinase TAK1 and therefore prevents aberrant lymphocyte activation [18,19], while A20 dampens NF-κB activity by trimming K63-ubiquitin chains attached to MALT1 ...
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Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction
... reduced ubiquitin levels [23] and altered NMJ structure [24] are observed in ax J mice prior to P8, we chose to study the effects of TgUsp14CA in wild type ...
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Reciprocal Activities between Herpes Simplex Virus Type 1 Regulatory Protein ICP0, a Ubiquitin E3 Ligase, and Ubiquitin-Specific Protease USP7
... E3 ubiquitin ligases whose levels are regulated at least in part by ...E3 ubiquitin ligase pro- teins by ubiquitin-specific protease enzymes has also been im- plicated in the ...
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Prevalence of Plasmodium falciparum delayed clearance associated polymorphisms in adaptor protein complex 2 mu subunit (pfap2mu) and ubiquitin specific protease 1 (pfubp1) genes in Ghanaian isolates
... interactions [21]. A high prevalence of novel ap2mu mu- tation, D168E (25%), was observed in the Ghanaian iso- lates from all three sites followed by V161K (7%). The codons for the common mutations found among the iso- ...
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A Gammaherpesvirus Ubiquitin-Specific Protease Is Involved in the Establishment of Murine Gammaherpesvirus 68 Infection
... Cell preparation and surface marker staining. Single-cell suspensions were prepared from spleens by mechanical disruption in ice-cold RPMI 1640 medium (Invitrogen Life Technologies, Carlsbad, CA) containing 10% fetal ...
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Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A
... Coronin was first identified as a soluble actin- binding protein of Dictyostelium discoideum [21]. Since then, several studies have evaluated actin-related roles of coronin and found that several coronin isoforms exist. ...
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Herpes Simplex Virus 1 Ubiquitin-Specific Protease UL36 Inhibits Beta Interferon Production by Deubiquitinating TRAF3
... removing polyubiquitin chain on TRAf3, and C40A HSV-1 infec- tion failed to deubiquitinate TRAF3, inducing more IFN- and ISGs expression than WT virus did. HSV-1 evolves multiple im- mune evasion strategies, and several ...
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Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer
... Several studies have shown that phosphorylation level proteins which involved ERKl/2/Akt signaling has emerged as a central feature of EMT, which is the initial step for metastasis in many cancer models [19, 22]. ...
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Tsg101 Interacts with Herpes Simplex Virus 1 VP1/2 and Is a Substrate of VP1/2 Ubiquitin-Specific Protease Domain Activity
... detergent-soluble membrane subdomain. Cargo sorting will start again once DUBs, by removing ubiquitin, reactivate Tsg101 (18). A similar mechanism has been shown in the case of the Epsin- dependent sorting ...
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miR-34b inhibits nasopharyngeal carcinoma cell proliferation by targeting ubiquitin-specific peptidase 22
... Materials and methods: The expression of miR-34b and transcription of ubiquitin-specific peptidase 22 (USP22) were examined using quantitative reverse transcription-polymerase chain reaction. Western ...
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Ubiquitin-specific protease 7 expression is a prognostic factor in epithelial ovarian cancer and correlates with lymph node metastasis
... Total cell extracts were prepared with NP-40 Buffer (50 mM Tris–HCl pH 7.5, 150 mM NaCl, 1% NP-40, 0.5% sodium deoxycholate) and protease inhibitor cocktails (1:1,000). Approximately 40 μ g of each protein sample ...
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Autocatalytic Activity of the Ubiquitin-Specific Protease Domain of Herpes Simplex Virus 1 VP1-2
... An N-terminal variant whose abundance is dependent upon functional USP activity. We next examined a series of N-ter- minal variants (Fig. 1a) which included progressively more of the protein, in particular extending ...
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The Ubiquitin-Specific Protease USP7 Modulates the Replication of Kaposi's Sarcoma-Associated Herpesvirus Latent Episomal DNA
... FIG 5 The LANA mutant lacking aa 971 to 986 shows enhanced replication of a plasmid containing the KSHV origin of latent replication. (A) Transient replication assay. 293 cells were cotransfected in duplicates with ...
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Ubiquitin-specific peptide 22 acts as an oncogene in gastric cancer in a son of sevenless 1-dependent manner
... peptide 22 (USP22) is a deubiqui- tinating enzyme that participates in the formation of a transcriptional regulatory histone acetylation ...removes ubiquitin from histones H2A and H2B, thereby modulating ...
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Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer
... Recently, ML323 and its derivatives were identified as more potent and specific Usp1/Uaf-1 inhibitors. Authors suggested that ML323 specificity was achieved by targeting the DUB complex as opposed to the Usp1 ...
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