ubiquitin specific protease 5
<p>Ubiquitin-specific protease 4 promotes glioblastoma multiforme via activating ERK pathway</p>
... Cell Counting Kit-8 (CCK-8, Beyotime, Shanghai, China) and annexin V Apoptosis Detection Kit (BD Biosciences, San Jose, CA, USA) were used to measure cell prolifera- tion and apoptosis, respectively. For cell ...
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Targeting ubiquitin-specific protease 22 suppresses growth and metastasis of anaplastic thyroid carcinoma
... Figure 3: Knockdown of USP22 inhibits ATC cell migration and invasion. CAL-62 and 8505C cells were untransfected (Mock) or transfected with pSilencer or pSi-shUSP22-1 plasmid. (A and B) After 48 h of transfection, the ...
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Reciprocal Activities between Herpes Simplex Virus Type 1 Regulatory Protein ICP0, a Ubiquitin E3 Ligase, and Ubiquitin-Specific Protease USP7
... Given the potentially competing effects of ICP0 and USP7 on each other, what is the principal biological significance of their interaction? The data suggest that during the initial stages of infection the dominant factor ...
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A Functional Ubiquitin-Specific Protease Embedded in the Large Tegument Protein (ORF64) of Murine Gammaherpesvirus 68 Is Active during the Course of Infection
... herpesvirus 5; Cahe3, Callitrichine herpesvirus 3; Ccy, Chimpanzee cytomeg- alovirus; Cehe1, Cercopithecine herpesvirus 1; Cehe15, Cercopithecine her- pesvirus 15; Cehe16, Cercopithecine herpesvirus 16; Cehe2, ...
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Ubiquitin-specific protease 7 expression is a prognostic factor in epithelial ovarian cancer and correlates with lymph node metastasis
... Survival information of 141 patients with EOC was obtained through letters and phone calls. The 5-year OS of the total patients was 62.34%, and the median sur- vival time was 78 months. The Kaplan–Meier univariate ...
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Prevalence of Plasmodium falciparum delayed clearance associated polymorphisms in adaptor protein complex 2 mu subunit (pfap2mu) and ubiquitin specific protease 1 (pfubp1) genes in Ghanaian isolates
... The sequence data of the isolates were analysed using the CLC Genomics Workbench 10.01 software (Qiagen, Aarhus, Denmark) and Benchling.com (California, CA, USA). PF3D7_1218300 and PF3D7_0104300 (PlasmoDB) were used as ...
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Original Article Ubiquitin-specific protease 22 as a prognostic biomarker in patients with various cancers: a meta-analysis
... cysteine protease family, Deubiquitinating enzymes not only regulate a number of cellular mechanisms, such as pre- implantation, growth and differentiation, onco- genesis, cell cycle progression, transcriptional ...
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Ubiquitin specific protease 19 involved in transcriptional repression of retinoic acid receptor by stabilizing CORO2A
... His-tagged ubiquitin was cloned as previously described ...were; 5’-GGA GGA GAU GGC AGU GGC A-3’. The anti-sense siRNA sequences were; 5‘-UGC CAC UGC CAU CUC CUC C-3’ (UbiProtein Corp, Seongnam, ...
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Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance
... We further verify the potential anti-tumor ability of P22077 on HCC cells, Huh7 and SK-Hep1 were treated with P22077 at a concentration of 5 µM, 10 µM and 20 µM. As shown in Fig. 3a, the number of cell foci were ...
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Herpes Simplex Virus 1 Ubiquitin-Specific Protease UL36 Abrogates NF-κB Activation in DNA Sensing Signal Pathway
... In the battle between host and viruses, viruses have evolved multiple strategies to antagonize the host innate immune defense. It has been documented that HSV-1 infection activates NF- B signaling, hijacks NF- B to ...
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Human Cytomegalovirus Protein pUL38 Prevents Premature Cell Death by Binding to Ubiquitin-Specific Protease 24 and Regulating Iron Metabolism
... whereby ferritin is degraded in lysosomes and releases free iron. Our results were consistent with the hypothesis that pUL38 suppresses ferritinophagy by modulating the activity of USP24, which in turn reduces the ...
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Ubiquitin-specific protease 22 is critical to in vivo angiogenesis, growth and metastasis of non-small cell lung cancer
... Since USP22 knockout significantly decreased the capacity of NHEJ, a major pathway for DNA DSBs repair, we further investigated whether USP22−/− cancer cells are more sensi- tive to irradiation that causes DSBs for ...
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Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer
... Tissue culture reagents were purchased from Sigma- Aldrich. LNCaP, CWR22Rv1, HEK293T and COS-7 cells were obtained from the American Type Culture Collection (Manassas, VA, USA). LNCaP-AI cells were derived in house as ...
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Ubiquitin-specific protease 11 functions as a tumor suppressor by modulating Mgl-1 protein to regulate cancer cell growth
... generated ubiquitin mutants that Lys was substituted with Arg (Figure 2D) ...of ubiquitin R48K chains with Mgl-1, we could detect USP11 deubiquitinating activity for Mgl-1 (Figure ...R63K ubiquitin ...
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Assess the expression of ubiquitin specific protease USP2a for bladder cancer diagnosis
... forward 5′-TGCTGAGACCCGACATCACT-3′; re- verse 5′-TGGGGTCTATCCGGTAGCTA-3′, as described in previous literature ...of 5 ml of 2 X SYBR premix EX Taq buffer, ...
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Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer
... Tissue culture reagents were purchased from Sigma- Aldrich. LNCaP, CWR22Rv1, HEK293T and COS-7 cells were obtained from the American Type Culture Collection (Manassas, VA, USA). LNCaP-AI cells were derived in house as ...
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Autocatalytic Activity of the Ubiquitin-Specific Protease Domain of Herpes Simplex Virus 1 VP1-2
... noticeable that levels of these N-terminal products were less affected by the C65A mutation. While there may be other explanations, this could be consistent with the results above, since these products, migrating around ...
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Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer
... The ubiquitin-proteasome pathway is an important intracellular protein degradation regulatory system ...The ubiquitin-specific proteases (USPs) are the largest subclass of DUBs ...moving ...
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Ubiquitin specific peptidase 5 regulates colorectal cancer cell growth by stabilizing Tu translation elongation factor
... subfamilies: ubiquitin-specific proteases, ubiquitin C-terminal hydrolases, ovarian tumor proteases, Josephins, JAMMs, and MINDYs ...[7]. Ubiquitin specific peptidase 5 (USP5) ...
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Structure and catalytic regulatory function of ubiquitin specific protease 11 N terminal and ubiquitin like domains
... for ubiquitin speci fi c proteases to be able to tightly regulate their catalytic activity as they occupy key positions in important signaling ...and 5), and solved the crystal structures of the human and ...
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