ubiquitin-specific protease 7
Ubiquitin specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis
... a specific small-molecule antagonist toward the cata- lytic activity of USP7 (47, 74) or attenuate ubiquitin binding (48, ...K48-linked ubiquitin chains for binding to USP7, destabilize MDC1, thereby ...
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Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance
... P22077 treatment not only induced cell death but also inhibited cell proliferation and migration in Huh7 and SK-Hep1 cells.. In a xenograft model, P22077 efficiently inhibited tumor gr[r] ...
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Ubiquitin-specific protease 7 expression is a prognostic factor in epithelial ovarian cancer and correlates with lymph node metastasis
... Total cell extracts were prepared with NP-40 Buffer (50 mM Tris–HCl pH 7.5, 150 mM NaCl, 1% NP-40, 0.5% sodium deoxycholate) and protease inhibitor cocktails (1:1,000). Approximately 40 μ g of each protein sample ...
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Tsg101 Interacts with Herpes Simplex Virus 1 VP1/2 and Is a Substrate of VP1/2 Ubiquitin-Specific Protease Domain Activity
... tegument ubiquitin-specific protease (htUSP) ...recruit specific cellular factors, Tsg101, Nedd4-like ubiquitin ligases, and AIP1, respectively ...of specific proteins during ...
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A Gammaherpesvirus Ubiquitin-Specific Protease Is Involved in the Establishment of Murine Gammaherpesvirus 68 Infection
... a ubiquitin (Ub)-specific cysteine protease (USP) domain embedded within the large tegument protein ORF64, as do all other ...this protease is still unclear, but for the alphaherpesvirus ...
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Herpes Simplex Virus 1 Ubiquitin-Specific Protease UL36 Inhibits Beta Interferon Production by Deubiquitinating TRAF3
... Papain-like protease (PLpro) of foot-and-mouth disease virus (FMDV), a pa- pain-like proteinase which acts as a viral DUB, was reported to decrease IRF3/7 expression and inhibit activation of NF-B, sup- ...
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Original Article Ubiquitin-specific protease 22 as a prognostic biomarker in patients with various cancers: a meta-analysis
... USP22 plays a key role in many aspects, includ- ing cell cycle regulation, embryo development, telomere homeostasis, therapy resistance, tu- mor progression and tumor metastasis [10, 13-16]. The elevated expression of ...
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Prevalence of Plasmodium falciparum delayed clearance associated polymorphisms in adaptor protein complex 2 mu subunit (pfap2mu) and ubiquitin specific protease 1 (pfubp1) genes in Ghanaian isolates
... interactions [21]. A high prevalence of novel ap2mu mu- tation, D168E (25%), was observed in the Ghanaian iso- lates from all three sites followed by V161K (7%). The codons for the common mutations found among the ...
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Mutagenesis of the Active-Site Cysteine in the Ubiquitin-Specific Protease Contained in Large Tegument Protein pUL36 of Pseudorabies Virus Impairs Viral Replication In Vitro and Neuroinvasion In Vivo
... Interestingly, in previous studies using a PrV mutant lacking the complete deubiquitinating module (PrV-UL36 ⌬ 22–248 [7]) we observed a reduction in viral titers which was similar to that of PrV-UL36(C 26 S), ...
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The Ubiquitin-Specific Protease USP7 Modulates the Replication of Kaposi's Sarcoma-Associated Herpesvirus Latent Episomal DNA
... repair proteins, proteins involved in immune responses, viral pro- teins, and epigenetic modulators. It was identified to be a key player in the p53-Mdm2 pathway as it can deubiquitinate both p53 and Mdm2, with higher ...
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Targeting ubiquitin-specific protease 22 suppresses growth and metastasis of anaplastic thyroid carcinoma
... ATC is a highly aggressive malignant cancer with a dismal prognosis [19]. Understanding the novel mechanisms of ATC development and identifying new targets to prevent ATC progression are the main challenges in the ...
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Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer
... The ubiquitin-proteasome pathway is an important intracellular protein degradation regulatory system ...The ubiquitin-specific proteases (USPs) are the largest subclass of DUBs ...moving ...
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Negative regulation of NF-κB signaling in T lymphocytes by the ubiquitin-specific protease USP34
... Nuclear factor-κB (NF-κB) transcription factors initiate transcription of genes essential for mounting an adequate immune response [1]. Ubiquitously expressed NF-κB heterodimers of Rel family proteins are normally ...
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Reciprocal Activities between Herpes Simplex Virus Type 1 Regulatory Protein ICP0, a Ubiquitin E3 Ligase, and Ubiquitin-Specific Protease USP7
... E3 ubiquitin ligase activity of ICP0, distinct from that of the RING finger, conferred by the region of ICP0 that includes the USP7 binding domain (20, ...(Fig. 7) correlates with reduced gene expression by ...
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Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction
... Figure 7 Inhibition of pJNK improves the structural and functional deficits caused by inhibition of USP14 ’ s DUB activity. (A) Representative immunoblots of pJNK1/2 and JNK1/2 in spinal cords from 5-week-old wild ...
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Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer
... (DUB), ubiquitin specific protease 12 (Usp12) as a positive regulator of the AR responsible for deubiquitinating and subsequently stabilising the ...
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Autocatalytic Activity of the Ubiquitin-Specific Protease Domain of Herpes Simplex Virus 1 VP1-2
... sons within the alphaherpesviruses and across the family her- pesviridae (see Fig. S1 in the supplemental material) indicate an overall organization whereby the N-terminal USP is linked via a poorly conserved region, of ...
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Ubiquitin-specific protease 22 is critical to in vivo angiogenesis, growth and metastasis of non-small cell lung cancer
... cycle progression, EMT, RAS, c-Myc signaling pathways; and concurrently enhanced oxidative phosphorylation and tight junction signaling pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG) in the two cells. ...
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Assess the expression of ubiquitin specific protease USP2a for bladder cancer diagnosis
... A promising finding by a research team led by François Radvanyi, along with previous studies from this group and from other laboratories [7–9], provided persuasive evi- dence that a certain subtype of ...
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Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer
... (DUB), ubiquitin specific protease 12 (Usp12) as a positive regulator of the AR responsible for deubiquitinating and subsequently stabilising the ...
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