Ubiquitin specific protease 7 (USP7)
Ubiquitin-specific protease 7 expression is a prognostic factor in epithelial ovarian cancer and correlates with lymph node metastasis
... that USP7 can act as an independent prognostic factor (hazard ratio [HR] = ...and USP7 expres- sion are all risk factors and have a strong impact on prognosis of EOC (Table ...
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Ubiquitin specific protease 7 sustains DNA damage response and promotes cervical carcinogenesis
... both USP7 and MDC1 were significantly overexpressed in a subset of patients with cervical cancer, and the levels of these 2 factors positively correlated with each ...Targeting USP7 may thus provide an ...
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Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance
... deubiquitylase USP7 is reported to be a prognostic factor in osteogenic sarcoma, T-cell lym- phoma and ovarian cancers ...of USP7 is correlated with poorer survival ...the USP7 inhibitor P5091 was ...
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Structure and catalytic regulatory function of ubiquitin specific protease 11 N terminal and ubiquitin like domains
... family USP7/HAUSP. 5,6 The 105 kDa ubiquitin speci fi c protease 11 (USP11) regulates vital signaling pathways in the ...pathway 7 and interacts with the NF- κ B transcription factor ...
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Impact of the Interaction between Herpes Simplex Virus Type 1 Regulatory Protein ICP0 and Ubiquitin-Specific Protease USP7 on Activation of Adeno-Associated Virus Type 2 rep Gene Expression
... E3 ubiquitin ligase ac- tivity (2), and the domain involved in its interaction with the ubiquitin-specific protease USP7 ...(6). USP7 contributes to the functions of ICP0, since ...
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A Gammaherpesvirus Ubiquitin-Specific Protease Is Involved in the Establishment of Murine Gammaherpesvirus 68 Infection
... Replacement of the active-site cysteine in the MDV deubiq- uitinating protein DUB led to a slight reduction in replication and plaque size in vitro, while early replication in chickens in vivo was unaffected (18). An ...
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Targeting ubiquitin-specific protease 22 suppresses growth and metastasis of anaplastic thyroid carcinoma
... ATC is a highly aggressive malignant cancer with a dismal prognosis [19]. Understanding the novel mechanisms of ATC development and identifying new targets to prevent ATC progression are the main challenges in the ...
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Tsg101 Interacts with Herpes Simplex Virus 1 VP1/2 and Is a Substrate of VP1/2 Ubiquitin-Specific Protease Domain Activity
... tegument ubiquitin-specific protease (htUSP) ...recruit specific cellular factors, Tsg101, Nedd4-like ubiquitin ligases, and AIP1, respectively ...of specific proteins during ...
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Prevalence of Plasmodium falciparum delayed clearance associated polymorphisms in adaptor protein complex 2 mu subunit (pfap2mu) and ubiquitin specific protease 1 (pfubp1) genes in Ghanaian isolates
... The search for a molecular marker for the early detec- tion of ART resistance by the malaria parasite is on- going. The use of molecular markers to track and identify early development of parasite resistance to drugs is ...
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Mutagenesis of the Active-Site Cysteine in the Ubiquitin-Specific Protease Contained in Large Tegument Protein pUL36 of Pseudorabies Virus Impairs Viral Replication In Vitro and Neuroinvasion In Vivo
... Interestingly, in previous studies using a PrV mutant lacking the complete deubiquitinating module (PrV-UL36 ⌬ 22–248 [7]) we observed a reduction in viral titers which was similar to that of PrV-UL36(C 26 S), ...
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Autocatalytic Activity of the Ubiquitin-Specific Protease Domain of Herpes Simplex Virus 1 VP1-2
... sons within the alphaherpesviruses and across the family her- pesviridae (see Fig. S1 in the supplemental material) indicate an overall organization whereby the N-terminal USP is linked via a poorly conserved region, of ...
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Original Article Ubiquitin-specific protease 22 as a prognostic biomarker in patients with various cancers: a meta-analysis
... cutoff value, treatment of the patients, survival outcome, and duration of follow up. Clini- copathological features data including gender, tumor stage, histological grade and lymph node metastasis were reviewed. The HRs ...
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Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction
... Figure 7 Inhibition of pJNK improves the structural and functional deficits caused by inhibition of USP14 ’ s DUB activity. (A) Representative immunoblots of pJNK1/2 and JNK1/2 in spinal cords from 5-week-old wild ...
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Ubiquitin-specific protease 22 is critical to in vivo angiogenesis, growth and metastasis of non-small cell lung cancer
... cycle progression, EMT, RAS, c-Myc signaling pathways; and concurrently enhanced oxidative phosphorylation and tight junction signaling pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG) in the two cells. ...
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Negative regulation of NF-κB signaling in T lymphocytes by the ubiquitin-specific protease USP34
... Nuclear factor-κB (NF-κB) transcription factors initiate transcription of genes essential for mounting an adequate immune response [1]. Ubiquitously expressed NF-κB heterodimers of Rel family proteins are normally ...
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Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer
... The ubiquitin-proteasome pathway is an important intracellular protein degradation regulatory system ...The ubiquitin-specific proteases (USPs) are the largest subclass of DUBs ...moving ...
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Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer
... (DUB), ubiquitin specific protease 12 (Usp12) as a positive regulator of the AR responsible for deubiquitinating and subsequently stabilising the ...
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Herpes Simplex Virus 1 Ubiquitin-Specific Protease UL36 Inhibits Beta Interferon Production by Deubiquitinating TRAF3
... Papain-like protease (PLpro) of foot-and-mouth disease virus (FMDV), a pa- pain-like proteinase which acts as a viral DUB, was reported to decrease IRF3/7 expression and inhibit activation of NF-B, sup- ...
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Assess the expression of ubiquitin specific protease USP2a for bladder cancer diagnosis
... A promising finding by a research team led by François Radvanyi, along with previous studies from this group and from other laboratories [7–9], provided persuasive evi- dence that a certain subtype of ...
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Ubiquitin-specific protease 12 interacting partners Uaf-1 and WDR20 are potential therapeutic targets in prostate cancer
... (DUB), ubiquitin specific protease 12 (Usp12) as a positive regulator of the AR responsible for deubiquitinating and subsequently stabilising the ...
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