Uncoupling Protein 2
Uncoupling protein 2 regulates myocardial apoptosis via the diabetogenic action of streptozotocin
... of uncoupling protein 2 (UCP2) in the myocardial apoptosis of diabetic melli- tus （ DM ） ...relative protein for myocardial apoptosis, pro-caspase-9, were investigated using western ...
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Uncoupling protein 2 polymorphisms as risk factors for NTDs
... women. Uncoupling Protein 2 (UCP2) is an attractive candidate to screen for NTD risk because of its possible role in obesity as well as energy metabolism, type-2 diabetes, and the regulation ...
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Original Article Effect of epigallocatechin gallate on uncoupling protein 2 in acute liver injury
... Total RNA was extracted from the liver of mice using the Trizol reagent (Sigma, US) based on the manufacturer’s instructions. One micro- gram of total RNA was reverse-transcribed using the High-Capacity cDNA Reverse ...
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Increased uncoupling protein 2 and 3 mRNA expression during fasting in obese and lean humans
... Uncoupling protein-2 and -3 (UCP2 and UCP3) are mito- chondrial proteins that show high sequence homology with the brown adipocyte–specific ...by uncoupling respiration from ATP ...
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Uncoupling protein 2 G(-866)A polymorphism: a new gene polymorphism associated with C-reactive protein in type 2 diabetic patients C-reactive protein in type 2 diabetic patients
... Reactive Protein (CRP), an acute phase protein synthe- sized primarily by the liver, is the most widely used bio- marker of inflammation and is also a powerful risk marker for cardiovascular diseases ...
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The Deletion Polymorphism in Exon 8 of Uncoupling Protein 2 is Associated with Severe Obesity in a Saudi Arabian Case-Control Study
... carrier Uncoupling protein 2 (UCP2) is a member of the mitochondrial anion carrier protein subfamily, (which also includes UCP1, 3, 4, and ...5). Uncoupling proteins function to ...
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Superoxide mediated activation of uncoupling protein 2 causes pancreatic β cell dysfunction
... phenomenon that includes loss of glucose sensing, resulting in impairment of glucose-stimulated insulin secretion (GSIS); increased basal insulin secretion; decreased islet insulin content; altered gene transcrip- tion; ...
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Acetoacetate reduces growth and ATP concentration in cancer cell lines which over-express uncoupling protein 2
... The UCP2 ELISA sandwich assay demonstrated a linear relationship for the standard curve of UCP2 antigen (Bio- legend) vs. ELISA (r = 0.988) (Figure 1A). Lysates of RFP3, SW48 and MDA MB 231 were also assayed at varying ...
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Both ischemic preconditioning and ghrelin administration protect hippocampus from ischemia/reperfusion and upregulate uncoupling protein-2
... Second, because of previous reports on UCP2 antibody problems (e.g. [40], we compared the antibody used for relative quantification (C-terminal peptide) with one raised against an N-terminal peptide (Fig 2 and 3). ...
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Antagonistic effect of TNF-alpha and insulin on uncoupling protein 2 (UCP-2) expression and vascular damage
... Male mice were maintained in the Animal Care Facility under the standard conditions of temperature and 12 h light/dark cycle. All animals from three experimental models used are under C57BL/6 genetic background. Male ...
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Uncoupling protein 2 gene polymorphisms are associated with obesity
... The commonly observed UCP2 gene single nucleotide polymorphisms (SNPs) G(−866)A in the promoter region (rs659366) and Ala55Val (a C to T substitution) in exon 4 (rs660339) have been associated with obesity and T2DM to a ...
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Inhibition of uncoupling protein 2 with genipin exacerbates palmitate-induced hepatic steatosis
... The current concept suggests that the oxidative stress plays an important role in the development of hepatic steatosis. UCP2, a well-established uncoupling protein, has been viewed as an inhibitor of ...
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Circulating levels of mitochondrial uncoupling protein 2, but not prohibitin, are lower in humans with type 2 diabetes and correlate with brachial artery flow-mediated dilation
... The prevalence of diabetes mellitus (DM) is increasing worldwide with an estimated 425 million people with DM in 2017 [1]. Diabetes mellitus type 2 (T2DM) is a chronic metabolic disease associated with dysfunction ...
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The uncoupling protein 1 gene, UCP1, is expressed in mammalian islet cells and associated with acute insulin response to glucose in African American families from the IRAS Family Study
... between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabo- lism/obesity in Pima ...the uncoupling protein 2 gene on 24-h energy expenditure and substrate ...
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Anti-obesity efficacy of nanoemulsion oleoresin capsicum in obese rats fed a high-fat diet
... binding protein (SREBP)-1c, and fatty acid-binding protein 2 (aP2), were analyzed in white adipose tissue ...and uncoupling protein-2 (UCP2), involved in β -oxidation and ...
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Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes
... Based on the putative topology of UCP3, the missense amino acid substitutions were located in the third, matrix- orientated, extramembranous loop (R143X); the first, cytosol- orientated, loop (V102I); and the sixth, ...
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Genome Wide Effects of Selenium and Translational Uncoupling on Transcription in the Termite Gut Symbiont Treponema primitia
... ited protein synthesis as well as the nature of mRNA secondary structure or other, as-yet-unknown factors that may be responsi- ble for prematurely terminating or pausing transcription of genes during inhibited ...
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A liver stress endocrine nexus promotes metabolic integrity during dietary protein dilution
... a protein-diluted diet, and wheth- er these effects were influenced by ambient environmental tem- ...the protein-diluted diet (Supplemental Figure 1F), again reflecting a feed ineffi- ...VO 2 was ...
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Genetic and epigenetic interactions in adaptive thermogenesis pathways in association with obesity from a Public Health Genomics perspective
... mellitus 2, cardiovascular and musculoskeletal systems diseases and some types of cancers as for example oesophagus, pancreas, colon, rectum, breast (after menopause), endometrium (lining of the uterus), kidney, ...
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Insights into brown adipose tissue evolution and function from non model organisms
... and protein was investigated, demonstrating that no protein is translated in pigs (Hou et ...alternative uncoupling protein (Lin et ...an uncoupling artefact (Cadenas et ...
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