Uncoupling Protein of Brown Fat
The role of uncoupling protein 3 in human physiology
... Third, the authors studied human beings. While transgenic mice experi- ments have been highly prized by first- line biomedical journals, experiments involving human physiology have been relatively undervalued in my ...
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Yes, even human brown fat is on fire!
... characteristic protein uncoupling protein 1 (UCP1) to allow for combustion of food energy in the brown fat ...this, brown fat pro- duces heat for defense against cold — ...
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On Novel Features of the Proton Leak and Possibility of Uncoupling Population of Mitochondria in Brown Adipose Tissue
... since uncoupling proteins (UCPs) were found in many ...an uncoupling protein localized in inner membrane of all mitochondria of this tissue [9, ...of brown fat may allow to reveal the ...
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Cold acclimation recruits human brown fat and increases nonshivering thermogenesis
... active brown adipose tissue (BAT) depots, raising the question of whether activation and recruitment of BAT can be a target to counterbalance the current obesity ...mitochondrial uncoupling to the increased ...
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Expression of uncoupling protein in skeletal muscle and white fat of obese mice treated with thermogenic beta 3 adrenergic agonist
... The most surprising finding of the present study was the appearance of UCP in skeletal muscle. Northern and Western blot analyses demonstrated a significant expression of UCP in gastrocnemius and quadriceps muscles of ...
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Effects of mutations in the human uncoupling protein 3 gene on the respiratory quotient and fat oxidation in severe obesity and type 2 diabetes
... and fat feeding in rodents (2, 9, 10). In the mouse, brown adipose tissue appears to be an important regulator of high fat diet–induced obesity, possibly mediated by UCP1 and UCP2 ...
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Miglitol increases energy expenditure by upregulating uncoupling protein 1 of brown adipose tissue and reduces obesity in dietary-induced obese mice
... Discussion Our data show that miglitol reduced body weight gain and insulin resistance, consistent with a previous study using spontaneous-onset obese type 2 diabetes mice [11]. Recent studies have focused on BAT as a ...
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Differences between white, brown and brite fat tissue
... the fat metabolism, discovered the nuclear receptor PPARy, which controls fat development and the development of type 2 ...induces uncoupling protein 1 (UCP1) expression, thereby enhancing ...
Rhein Protects against Obesity and Related Metabolic Disorders through Liver X Receptor-Mediated Uncoupling Protein 1 Upregulation in Brown Adipose Tissue
... coupling protein 1 (UCP1) expression in brown adipose tissue (BAT) in wild-type mice, but did not affect UCP1 expression in LXR knockout ...HIB-1B brown adipocytes, rhein activated the UCP1 gene by ...
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Augmenting energy expenditure by mitochondrial uncoupling: a role of AMP-activated protein kinase
... body fat in the absence of changes in physical activity is to decrease the efficiency of energy conversion or to decrease food intake (Hoehn et ...thermogenic brown adipocytes containing endogenous UCP1 by ...
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Uncoupling proteins, dietary fat and the metabolic syndrome
... UCP2 protein is a negative regulator of insulin secretion by pancreatic β -cells is also strong: increased UCP2 decreases glucose stimulated insulin secretion ultimately leading to β -cell ...
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Overexpression of uncoupling protein 3 in skeletal muscle protects against fat induced insulin resistance
... against fat-induced insulin resistance in muscle by conversion of intramyocellular fat into thermal ...against fat-induced defects in insulin signaling and action in these ...whole-body ...
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Body fat mass reduction and up-regulation of uncoupling protein by novel lipolysis-promoting plant extract
... body fat mass systemi- cally or regionally, accompanied by the up-regulation of ...to fat reduction or the modification of fat distribution and expression of ...systematic fat reduction or the ...
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The genetic association study between polymorphisms in uncoupling protein 2 and uncoupling protein 3 and metabolic data in dogs
... Conclusions A genetic association study between polymorphisms in the dog uncoupling protein 2 and 3 genes and metabolic data showed that the SNPs of the UCP3 intron 1 were associated with T-Cho levels in ...
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Mitochondrial uncoupling protein 1 expression in thymocytes
... In addition we also looked at the level of expression of the Cell death Inducing DNA fragmentation factor (DFF), alpha subunit-like Effector A (CIDEA) in UCP 1 wild-type and UCP 1 knock-out mice. Zhou et al. [13] have ...
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HIBERNOMA - A RARE BROWN FAT TUMOUR
... of brown fat. It is also known as lipoma of brown adipose tissue, lipoma glandular and atypical ...the brown fat of hibernating animals 2 ...
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The “Skinny” on brown fat, obesity, and bone
... and fat metabolism as well as mitochondrial heat dissipation, is common to the Neandertal, the Denisovan, and 87% of East Asians, while a derived allele for PPARGC1B is common to the two hominins sampled and ...
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Uncoupling protein 2 gene polymorphisms are associated with obesity
... lipids. Uncoupling protein 2 has been reported to play an im- portant role in the regulation of human energy metabol- ism, through its functions of proton gradient dissipation, and uncoupling of ...
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Involvement of Drosophila Uncoupling Protein 5 in Metabolism and Aging
... Manuscript received November 10, 2005 Accepted for publication December 30, 2005 ABSTRACT A novel uncoupling protein, UCP5, has recently been characterized as a functional mitochondrial uncoupler in ...
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Uncoupling protein 2 polymorphisms as risk factors for NTDs
... women. Uncoupling Protein 2 (UCP2) is an attractive candidate to screen for NTD risk because of its possible role in obesity as well as energy metabolism, type-2 diabetes, and the regulation of reactive ...
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