Unilateral ureteral obstruction
Hydraulic water permeability and transepithelial voltage in the isolated perfused rabbit cortical collecting tubule following acute unilateral ureteral obstruction
... Ureteral obstruction affects the kidney's ability to conserve water and sodium. Using the isolated perfused tubule technique, we studied cortical collecting tubules (CCT) taken from rabbits subjected to a ...
8
The relative contribution of urine extravasation to elevation of plasma creatinine levels in acute unilateral ureteral obstruction
... acute unilateral ureteral obstruction (AUUO) often reflects acute renal failure, mandating kidney ...underwent unilateral ligation of the ureter with infiltration of rat’s urine (index group) ...
6
Alteration of renal cyclooxygenase expression due to partial unilateral ureteral obstruction in neonatal
... Introduction: Impaired renal water handling in response to neona- tally-induced partial unilateral ureteral obstruction (PUUO) may be associated with altered expression of cyclooxygenase (COX). The ...
6
Chitosan/siRNA Nanoparticles Targeting Cyclooxygenase Type 2 Attenuate Unilateral Ureteral Obstruction-induced Kidney Injury in Mice
... Cyclooxygenase type 2 (COX-2) plays a predominant role in the progression of kidney injury in obstructive nephropathy. The aim of this study was to test the efficacy of chitosan/small interfering RNA (siRNA) ...
14
Electrical properties of the rabbit cortical collecting duct from obstructed kidneys after unilateral ureteral obstruction Effects of renal decapsulation
... Ureteral obstruction causes impaired salt wastage and K+ secretion in the distal nephron segments, including the cortical collecting duct ...after unilateral ureteral obstruction ...of ...
10
Deep nephron function after release of acute unilateral ureteral obstruction in the young rat
... acute unilateral ureteral obstruction (UUO) of 18 h duration on deep nephron function was evaluated in 14 weanling rats with the technique of ...
13
Intermedin attenuates renal fibrosis by induction of heme oxygenase-1 in rats with unilateral ureteral obstruction
... ameliorated unilateral ureteral obstruction (UUO)-mediated fibronectin up- regulation and the fibrotic changes, and the anti- fibrotic effect is achieved by inhibition of oxidative stress ...
11
Original Article Screening and identification of the differential proteins in kidney with complete unilateral ureteral obstruction
... Abstract: Obstructive nephropathy is a major cause of renal failure, particularly in infants and children, and indica- tions for therapeutic intervention remain highly controversial. There is a great need for the ...
12
Mesenchymal stem cell-derived microparticles ameliorate peritubular capillary rarefaction via inhibition of endothelial-mesenchymal transition and decrease tubulointerstitial fibrosis in unilateral ureteral obstruction
... Figure 6 Anti-apoptotic effects of in vivo engrafted-MPs in UUO kidneys. Confocal laser microscopy confirms the engraftment of red CellTracker ™ labeled MPs and TUNEL staining in UUO kidneys. High-power fields in which ...
12
Lipopolysaccharide-induced inflammation or unilateral ureteral obstruction yielded multiple types of glycosylated Lipocalin 2
... ments, unilateral ureteral ligation successfully upregu- lated the 22-kDa LCN2 expression on the obstructed side of the ureter without affecting the opposite side ...tract obstruction upregulates the ...
10
Assessment of renal function in mice with unilateral ureteral obstruction using 99mTc-MAG3 dynamic scintigraphy
... Tc-MAG3 flows into renal tissue, can be used as an indicator of renal perfusion and tubular uptake, while the descending phase provides an assessment of tubular excretion [4,5] (Additional file 1). Thus, the measure- ...
11
Interferon gamma peptidomimetic targeted to interstitial myofibroblasts attenuates renal fibrosis after unilateral ureteral obstruction in mice
... To assess whether treatment with Fibroferon reduces systemic side effects compared with non-targeted full length IFNγ, brain MHC class II mRNA expression as a measure of IFNγ-induced mic[r] ...
13
Electrical properties of the rabbit cortical collecting duct from obstructed and contralateral kidneys after unilateral ureteral obstruction
... Abbreviations used in this paper: CCD, cortical collecting duct; CD cell, collecting duct cell; control, sham operation; DOCA, deoxycorticosterone acetate; ZXEMF, change in basolateral m[r] ...
12
Targeted disruption of TGF β1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
... In situ hybridization of TGF-β1 mRNA was enhanced in renal tubules and mononuclear cells, consisting mostly of monocytes, infiltrating the interstitium of the obstructed kidneys in wild-[r] ...
10
The Impact of Gender on AQP1–3 Expression in Response to Neonatal Partial Unilateral Ureteral Obstruction
... The consequence of obstruction is characteristically impairment of urinary concentration capacity. This involves two renal tubule segments: the loop of Henle and the collecting duct. The loop of Henle is in a ...
8
Inhibition of COX 1 and 2 prior to Renal Ischemia/Reperfusion Injury Decreases the Development of Fibrosis
... to unilateral ureteral obstruction, a model of renal fibrosis, the increased ex- pression of BMP-7 was associated with less renal fibrosis ...a unilateral ureteral obstruction ...
7
Treatment outcomes of ureteral stenting for malignant extrinsic ureteral obstruction: a comparison between polymeric and metallic stents
... study cohort, the stent patency rate was 86.0% at 6 months and 60.0% at 1 year. Nephrostomy was required in 8 cases (15.4%), due to stent failure. In addition, the occlusion rate was significantly higher for bilateral ...
6
Antifibrotic vitamin D analogs
... In a mouse model of unilateral ureteral obstruction UUO, which is well known for its rapid development of fibrotic kidney disease, treatment with 1,25OH2D3 markedly reduced TGF-β–stimula[r] ...
5
Protective effect of miRNA-containing extracellular vesicles derived from mesenchymal stromal cells of old rats on renal function in chronic kidney disease
... UUO: Unilateral ureteral obstruction; TGF- β 1: Transforming growth factor- β 1; HK2: Human renal proximal tubular epithelial; EMT: Epithelial-mesenchymal transition; ESRD: End-stage renal disease; ...
14
RIPK3 promotes kidney fibrosis via AKT-dependent ATP citrate lyase
... TGF-β1 can activate the serine/threonine kinase AKT by inducing its phosphorylation in fibroblasts (10). AKT regulates many cellular processes, including cell survival, proliferation, and metabolism (11, 12). AKT ...
15