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untargeted metabolomics

A Guideline to Univariate Statistical Analysis for LC/MS-Based Untargeted Metabolomics-Derived Data

A Guideline to Univariate Statistical Analysis for LC/MS-Based Untargeted Metabolomics-Derived Data

... pilot untargeted metabolomics study to determine minimum sample size? In practice, ethical and economical restrictions mainly determine the number of samples ...

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Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk

Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk

... of untargeted metabolomics studies, the majority of spectral features detected in biological matrices arise from metabolites of unknown structural identity ...because untargeted metabolomics ...

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Copper oxide nanoparticle toxicity profiling using untargeted metabolomics

Copper oxide nanoparticle toxicity profiling using untargeted metabolomics

... The untargeted metabolomics approach was shown to be a particularly sensitive method, and able to detect subtle metabolic changes in A549 cells upon exposure of CuO ...highlighting untargeted ...

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MINEs: open access databases of computationally predicted enzyme promiscuity products for untargeted metabolomics

MINEs: open access databases of computationally predicted enzyme promiscuity products for untargeted metabolomics

... is untargeted metabolomics, which seeks to measure as much of the metabolome as possible by limiting methodological detection ...for untargeted metabo- lomics is chromatography coupled with mass ...

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Untargeted metabolomics profiling of an 80.5 km simulated treadmill ultramarathon

Untargeted metabolomics profiling of an 80.5 km simulated treadmill ultramarathon

... The clearest impact of endurance exercise is on fatty acid metabolism but with respect to formation of medium-chain unsaturated and partially oxidized fatty acids and conjugates of fatty acids with carnitines. The most ...

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Metabolic reprogramming and redox adaptation in sorafenib-resistant leukemia cells: detected by untargeted metabolomics and stable isotope tracing analysis

Metabolic reprogramming and redox adaptation in sorafenib-resistant leukemia cells: detected by untargeted metabolomics and stable isotope tracing analysis

... global untargeted metabolomics and stable isotope‑labe‑ ling mass spectrometry analysis to identify the metabolic alterations relevant to the therapeutic ...

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Comparing the antidiabetic effects and chemical profiles of raw and fermented Chinese Ge-Gen-Qin-Lian decoction by integrating untargeted metabolomics and targeted analysis

Comparing the antidiabetic effects and chemical profiles of raw and fermented Chinese Ge-Gen-Qin-Lian decoction by integrating untargeted metabolomics and targeted analysis

... Then, untargeted metabolomics was performed to find statistically significant differences between GQD and FGQD groups via OPLS-DA S-plot and VIP-value analy- ...

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Metabolic derangements identified through untargeted metabolomics in a crosssectional study of Nigerian children with severe acute malnutrition

Metabolic derangements identified through untargeted metabolomics in a crosssectional study of Nigerian children with severe acute malnutrition

... Metabolomics Metabolic derangements identified through untargeted metabolomics in a cross sectional study of Nigerian children with severe acute malnutrition Manuscript Draft Manuscript Number MEBO D[.] ...

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Original Article Untargeted metabolomics analysis for a strain of Bacillus subtilis isolated from the oral cavity

Original Article Untargeted metabolomics analysis for a strain of Bacillus subtilis isolated from the oral cavity

... of metabolomics over the last decade, it is pos- sible to rapidly and simultaneously measure thousands of metabolites from minimal am- ounts of samples ...[14]. Untargeted metabolo- mic methods are global ...

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Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose

Probing the metabolic network in bloodstream-form Trypanosoma brucei using untargeted metabolomics with stable isotope labelled glucose

... mass-based metabolomics, as many isomers are theoretically possible for most carbohydrate metabolites; hence, additional orthog- onal approaches are required to confidently identify these ...

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Utilizing untargeted metabolomics to characterize microbial communities and identify biomarkers of an unhealthy state

Utilizing untargeted metabolomics to characterize microbial communities and identify biomarkers of an unhealthy state

... discovered that many metabolites discriminating BV from health are of unknown origin (i.e. 2HV, GHB, 2-hydroxyisocaproate, 2-hydroxyglutarate), with the genes responsible for their production either being poorly ...

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Untargeted metabolomics reveals molecular effects of

Untargeted metabolomics reveals molecular effects of

... and other metabolites involved in fatty acid metabolism in a lung cancer mouse model [48].. respect, our data suggests that the downregulation of tetradecanoylcarnitine and stearoylcarni[r] ...

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Untargeted metabolomics of extracts from faecal samples demonstrates distinct differences between paediatric Crohn's disease patients and healthy controls but no significant changes resulting from exclusive enteral nutrition treatment

Untargeted metabolomics of extracts from faecal samples demonstrates distinct differences between paediatric Crohn's disease patients and healthy controls but no significant changes resulting from exclusive enteral nutrition treatment

... investigation. Metabolomics is an indispensable research tool for the identification and tracking of biomarkers in biological systems and ...method, metabolomics presents a novel means of interrogating ...

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Metabolomics Analysis Identifies Sphingolipids as Key Signaling Moieties in Appressorium Morphogenesis and Function in Magnaporthe oryzae

Metabolomics Analysis Identifies Sphingolipids as Key Signaling Moieties in Appressorium Morphogenesis and Function in Magnaporthe oryzae

... used untargeted metabolomics analyses to profile the metabolome of developing appressoria and identified significant changes in six key metabolic pathways, including early sphingolipid ...

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Simultaneous untargeted and targeted metabolomics profiling of underivatized primary metabolites in sulfur-deficient barley by ultra-high performance liquid chromatography-quadrupole/time-of-flight mass spectrometry

Simultaneous untargeted and targeted metabolomics profiling of underivatized primary metabolites in sulfur-deficient barley by ultra-high performance liquid chromatography-quadrupole/time-of-flight mass spectrometry

... Background: Metabolomics based on mass spectrometry analysis are increasingly applied in diverse scientific domains, notably agronomy and plant biology, in order to understand plants’ behaviors under different ...

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Recent advances and perspectives of metabolomics-based investigations in Parkinson’s disease

Recent advances and perspectives of metabolomics-based investigations in Parkinson’s disease

... of untargeted metabolomics make it an effective tool for the discovery of novel PD ...GC-TOF/MS-based metabolomics, significant reduc- tions in tryptophan, creatinine, and 3-hydroxyisovalerate levels ...

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Potential role of metabolomics in the improvement of research on traditional African medicine

Potential role of metabolomics in the improvement of research on traditional African medicine

... Untargeted metabolomics approaches such as LC – MS and NMR allowfor a rapid, high-throughput and automated assessment of crude extracts and the quantitative detection of several different metabolites (Kim ...

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The metabolomics of psoriatic disease

The metabolomics of psoriatic disease

... and untargeted approaches. Targeted metabolomics involves the analysis of a prespecified set of metabolites, often related to a particular pathway or network of pathways of ...be untargeted, that is, ...

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Livestock metabolomics – A overview

Livestock metabolomics – A overview

... for untargeted metabolomics screenings and LC-MS based systems are a considerably demanding alternative in terms of time and costs to identify unknown compounds in complex samples (Nandi et ...

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From Sample to Multi-Omics Conclusions in under 48 Hours

From Sample to Multi-Omics Conclusions in under 48 Hours

... (LC-MS/MS) metabolomics through the Qiita, PICRUSt, and GNPS pipelines, ...diversity. Untargeted metabolomics revealed that human skin and fer- mented food samples had separate chemical ecologies and ...

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