UPLC-MS
A rapid and sensitive UPLC-MS/MS method for the determination of flibanserin in rat plasma: application to a pharmacokinetic study
... For the study of the pharmacokinetics, the current UPLC-MS/MS approach was applied efficiently for the determination of flibanserin in rat plasma at different time points. The blank rat plasma was ...
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<p>Validated UPLC-MS/MS method for quantification of fruquintinib in rat plasma and its application to pharmacokinetic study</p>
... adopted UPLC-MS/MS and the protein precipitation. Meanwhile, UPLC-MS/MS was available in most laboratories at ...of MS/MS conditions and chromatography had also ...
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Validation of an Analytical Methodology for the Determination of Chloramphenicol Residues in Honey using UPLC-MS/MS
... The aim of present study was to develop and validate a simple, precise, accurate and sensitive method for the identification, validation and quantification of Chloramphenicol (CAP) residues in honey using ultra ...
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Quantitative Evaluation of Twelve Major Components of Astragali Radix Sulfur-Fumigated with Different Durations by UPLC-MS
... improved UPLC-MS method for simultaneously quantifying twelve major components belonging to two chemical types was developed and validated, and was applied to quantitatively compare the quality of Astragali ...
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UPLC-MS/MS quantification of quercetin in plasma and urine following parenteral administration
... Results: We developed and validated a new method for quantification of Qu and its metabolites in human plasma and urine following intravenous administration of Qu formulation. The method is based on the solid-phase ...
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Efficient validated method of UPLC-MS/MS to determine curcumin in rat plasma and ovarium
... Two hundred microliter plasma or ovary homogenate contained a specific concentration of curcumin was added to 20 µl IS solution and 2 ml MTBE as an extracting solution. The sample was vortexed for 1 minute and ...
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<p>Simultaneous Determination of Parecoxib and Its Metabolite Valdecoxib Concentrations in Beagle Plasma by UPLC-MS/MS and Application for Pharmacokinetics Study</p>
... sensitive UPLC-MS/MS method for simultaneous determination of parecoxib and valdecoxib, and described the pharmacoki- netic characteristics of parecoxib and valdecoxib in bea- gles after injection of ...
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Photodegradation assessment of ciprofloxacin, moxifloxacin, norfloxacin and ofloxacin in the presence of excipients from tablets by UPLC-MS/MS and DSC
... In the presented paper we have developed and vali- dated an ultra-performance liquid chromatography method coupled with tandem mass spectrometry (UPLC-MS/MS) for the determination of CIP, MOX, NOR ...
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Monitoring of Pesticides in Drinking, Surface and Ground Water of Cyprus by Liquid Liquid and Solid Phase Extraction in Combination with GC/MS and UPLC/MS/MS
... Pesticides having different structures and biological activities are widely used for agricultural and non-agricultural purposes throughout the world. Moni- toring of pesticides in water contribute to the protection of ...
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Stability of Hydroxytyrosol in Aqueous Solutions at Different Concentration, Temperature and with Different Ionic Content: A Study Using UPLC MS
... The work describes a stability study of hydroxytyrosol (HTyr) in aqueous solutions carried out varying the following parameters: HTyr concentration, temperature and ionic content in the aqueous solution. First, an ...
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An UPLC-MS/MS method for highly sensitive high-throughput analysis of phytohormones in plant tissues
... Results: Here we present an LC-MS/MS method for fast and highly sensitive determination of jasmonates, abscisic and salicylic acids. A single-step sample preparation procedure based on mixed-mode solid ...
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A COMPARATIVE STUDY IN THE CONFIRMATORY METHOD DEVELOPMENT AND VALIDATION OF FLUBENDAZOLE IN FISH AND SHRIMP MUSCLES BETWEEN HPLC MS/MS (Q MICRO) AND UPLC MS/MS (TQD)
... (AQUITY UPLC–TQD) and in HPLC- MS/MS (Quattro micro) at same ...AQUITY UPLC BEH C18, 2.1x50mm, 1.7µm, Column in UPLC system) same mobile phase of ...
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UPLC-MS/MS Method for Simultaneous Quantification of Glimepiride and Metformin in Human Plasma
... 18. Sengupta, P., Bhaumik, U., Ghosh, A., Sarkar, A.K., Chatterjee B., Bose, A., Pal, T.K., LC–MS–MS development and validation for simultaneous quantitation of Metformin, Glimepiride and Pioglitazone in ...
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Development and Validation of an UPLC-ESI-MS/MS Analytical Method for the Determination of Streptomycin and Dihydrostreptomycin Residues in Honey
... The aim of present study was to develop and validate a rapid, precise, simple and sensitive method for the detection and quantification of streptomycin (STR) and dihydrostreptomycin (Di- STR) residues in honey using ...
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Untargeted Mass Spectrometry Lipidomics identifies correlation between serum sphingomyelins and plasma cholesterol
... Metabolome-wide association studies (MWAS) have been proposed to predict disease condition [10, 11] and have led to the identification of biomarkers associated with risk factors of chronic diseases such as hyperten- sion ...
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Investigation of in Vitro and in Vivo Metabolism of Schisandrin B from Schisandrae Fructus by Liquid Chromatography Coupled Electrospray Ionization Tandem Mass Spectrometry
... by UPLC-MS analyses and confirmed with MS/MS experiments in positive ESI ...both UPLC-MS data and MS/MS spectra of the peak at ...the UPLC-MS analysis ...
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Rapid differentiation of Xihuangcao from the three Isodon species by UPLC-ESI-QTOF-MS/MS and chemometrics analysis
... Based on the UPLC-MS data generated using the ref- erence plants, we proceeded to investigate the identi- fication of the 27 batches of commercial Xihuangcao. Fundamental morphologic and microscopic ...
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<p>Preparation and Evaluation of Cabazitaxel-Loaded Bovine Serum Albumin Nanoparticles for Prostate Cancer</p>
... by UPLC-MS/MS and MRI, and the results showed that CBZ-BSA- Gd-NPs could effectively target tumor tissues with reduced distribution in the heart, liver, spleen, lungs, and kidneys compared with ...
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Analytical methods for the determination of paracetamol, pseudoephedrine and brompheniramine in Comtrex tablets
... and UPLC-MS/ MS) for the separation and quantitation of PAR, PSE and BRM in their combined dosage form specifically as to the extent of our knowledge; from a detailed literature sur- vey that only ...
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Phytochemical profile of Orthosiphon aristatus extracts after storage: Rosmarinic acid and other caffeic acid derivatives
... Many phytochemicals, mostly organic acids, phenolic acids and flavonoids have been identified in the negative mode of UPLC-MS/MS. In particular, ca ff eic acid (3,4-dihydroxycinnamic acid) derived com- ...
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