UPS- Ubiquitin Proteasome System
Siepe, Dirk (2009): Role of the peptidyl-prolyl cis/trans isomerase Pin1 in the ubiquitin proteasome system (UPS). Dissertation, LMU München: Fakultät für Biologie
... endosomal/lysosomal system, the process of autophagy, which also involves the lysosome, and the ubiquitin proteasome system ...The UPS is the principal non-lysosomal system for ...
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The ubiquitin-proteasome system: A novel target for anticancer and anti-inflammatory drug research
... – ubiquitin-activating enzyme; E2 – ubiquitin-conjugating enzyme; E3 – ubiquitin-protein ligase; ET-1 – endothelin-1; Hdm2 – human counterpart of Mdm2; HIF-1 – hypoxia inducible factor; IKK – IκB ...
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Targeting the Ubiquitin Proteasome System in Cancer
... the UPS has significantly increased and it is evident that the UPS plays critical roles in various important cellular functions and can regulate both structural and functional behavior of ...of UPS ...
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TRIB2 and the ubiquitin proteasome system in cancer
... the ubiquitin proteasome system (UPS) are central to TRIB function in a number of cancers and will be discussed ...E3 ubiquitin ligase activities ...
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Role of the ubiquitin proteasome system in hematologic malignancies
... deregulated UPS pathway in hemato- logic ...the UPS to the develop- ment of hematologic malignancies and elucidate novel ave- nues for the development of novel treatments for hematopoietic ...
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The ubiquitin-proteasome system in glioma cell cycle control
... Last but not least, the induction of G0/G1 or G2/M cell cycle arrest and/or apoptosis, whenever indicated as a response to various stressors, could not be ensured without the critical involvement of p53, whose levels and ...
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Emerging therapies targeting the ubiquitin proteasome system in cancer
... Healthcare System, Pittsburgh, Pennsylvania, ...The ubiquitin proteasome system (UPS) is an essential metabolic constituent of cellular physiology that tightly regulates cellular ...
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Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy
... the UPS (Figure ...the UPS being one possible ...the UPS, and autophagy ...to proteasome inhibitors [13], and some yeast cells that adapted to aneuploidy were found to contain muta- tions that ...
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The possible role of the ubiquitin proteasome system in the development of atherosclerosis in diabetes
... that UPS may be involved in the genera- tion of insulin-resistance, diabetes, and cardiovascular ...The UPS is the main route of cellular protein deg- ...the UPS is involved in a number of biological ...
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Ubiquitin proteasome system dysfunction in experimental models of Parkinson's disease
... 2005). Therefore, it is likely that overexpression of A53T mutant may result in greater dieldrin-induced UPS dysfunction than impairment in wild type α-synuclein expressing cells. Recently, oxidative stress and ...
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The Ubiquitin-Proteasome System Is Necessary for Efficient Replication of Human Astrovirus
... the ubiquitin-proteasome system (UPS) in the replication of Yuc8, a human astrovi- rus serotype 8 ...that proteasome inhibitors decrease the production of infectious viral progeny at a ...
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Interplay between the Ubiquitin Proteasome System and Mitochondria for Protein Homeostasis
... the UPS substrates, which are ear-marked by ubiq- uitin, the autophagosome membrane is ear-marked by the small ubiquitin-like modifier Atg8 (LC3 in ...
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Dysregulation of the Ubiquitin-Proteasome System by Curcumin Suppresses Coxsackievirus B3 Replication
... the ubiquitin- proteasome system ...20S proteasome proteolytic activities and the cellular deubiquitinating activities, leading to increased accumulation of ubiq- uitinated proteins and ...
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The Roles of Ubiquitin-Binding Protein Shuttles in the Degradative Fate of Ubiquitinated Proteins in the Ubiquitin-Proteasome System and Autophagy.
... 8. Suggested Model and Concluding Remarks Proteasomal degradation and autophagy are two independent elements of the PQC system, but they act in a networked and interactive manner to maintain proteostasis. Multiple ...
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Polypharmacology of small molecules targeting the ubiquitin– proteasome and ubiquitin-like systems
... the ubiquitin–proteasome system (UPS) and ubiquitin-like signalling systems (UBL) has been considered a promising therapeutic strategy to treat cancer, neurodegenerative and ...
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Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease
... the UPS as a major and common (both CD and UC) contributor to IBD ...the UPS in IBD pathogenesis could have two origins, genetic and/or microbial, both of which being largely recognised as favouring the ...
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The interaction of hepatitis B virus with the ubiquitin proteasome system in viral replication and associated pathogenesis
... inhibit the activation of STING-stimulated IRF3 as well as the induction of IFN-β [62]. IFN, an immune molecule that could be induced by PRRs, has been successfully used for clinical treatment of patients with HBV ...
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HIV 1 Vpr activates the G2 checkpoint through manipulation of the ubiquitin proteasome system
... the UPS is required for Vpr to induce G 2 checkpoint activation, as incubation of Vpr-expressing cells with proteasome inhibitors abolishes this ...E3 ubiquitin ligase subunits that Vpr ...
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Ubiquitin Like Proteasome System Represents a Eukaryotic Like Pathway for Targeted Proteolysis in Archaea
... Here, we advance the fundamental knowledge of targeted pro- teolysis in archaeal cell biology by studying the SPS-mediated turnover of TATA-binding protein 2 (TBP2) through a mecha- nism apparently associated with ...
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Deregulation of the ubiquitin-proteasome system is the predominant molecular pathology in OPMD animal models and patients
... GT [16] was used to identify significant associations between GO categories or KEGG pathways and OPMD, while including age as a confounder (Drosophila and mice only). Gene sets with multiple testing adjusted (Holm’s ...
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