Urate crystals
Immunoglobulin G independent activation of the classical complement pathway by monosodium urate crystals
... monosodium urate crystals reduced the CH50 of 1 ml of human serum by 57% after 30 min at 37 degrees ...when urate crystals were incubated with isolated precursor C1, and required the intact ...
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Lipoproteins containing apoprotein B are a major regulator of neutrophil responses to monosodium urate crystals
... intraarticular urate crystals is known to be variable in gouty ...to urate crystals exposed to ...of crystals exposed to lipoprotein-depleted ...inhibited urate crystal-induced ...
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Release of platelet constituents by monosodium urate crystals
... monosodium urate crystal, is described ...to urate crystals proceeded in two phases: A secretory phase involved the rapid active release of serotonin, ATP, and ADP with little loss of lactic ...
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Apolipoprotein (apo) E inhibits the capacity of monosodium urate crystals to stimulate neutrophils Characterization of intraarticular apo E and demonstration of apo E binding to urate crystals in vivo
... monosodium urate crystals to stimulate leukocytes could regulate gouty ...to urate crystals and suppress crystal-neutrophil ...that urate crystals, coated with apo E of monocyte ...
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Role of the NLRP3 inflammasome in the transient release of IL-1β induced by monosodium urate crystals in human fibroblast-like synoviocytes
... In rheumatoid arthritis (RA), synovial fibroblasts play an important role in the process of cartilage and bone erosion, presumably via the synthesis of inflammatory mediators, including chemokines [28,29], matrix metal- ...
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MyD88 dependent IL 1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals
... that urate release from injured cells provides an adjuvant signal that alerts the immune system to dan- ger ...(27). Urate represented a new class of adjuvant molecules being produced by the host itself and ...
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High density lipoproteins downregulate CCL2 production in human fibroblast like synoviocytes stimulated by urate crystals
... MSU crystals, because similar results were obtained when FLS were pretreated with HDL before acti- vation by MSU crystals (Figure 3a, ...MSU crystals-induced production of IL-8 was inhibited in the ...
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Urate crystals stimulate production of tumor necrosis factor alpha from human blood monocytes and synovial cells Cytokine mRNA and protein kinetics, and cellular distribution
... monosodium urate (MSU) provide a dose-dependent stimulus for the production by human blood monocytes of tumor necrosis factor (TNF), a cytokine with proinflammatory properties; TNF activity was inhibited ...
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Enhanced interleukin 1β production of PBMCs from patients with gout after stimulation with Toll like receptor 2 ligands and urate crystals
... MSU crystals were prepared according to the method described by Seegmiller et al. [14]. Briefly, a solution of 0.03 M of MSU at a volume of 200 ml was prepared after diluting 1.0 g of uric acid (Sigma Co, St ...
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Monosodium urate crystals reduce osteocyte viability and indirectly promote a shift in osteocyte function towards a proinflammatory and proresorptive state
... MSU crystals alone did not induce IL-1β release in human or murine macrophages without additional priming of cells with either lipopoly- saccharide or phorbol 12-myristate 13-acetate [39, ...MSU crystals ...
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Monosodium urate crystals induce oxidative stress in human synoviocytes
... MSU crystals induce by currently unknown mechanisms ...MSU crystals in an in vitro model of crystal-induced ...MSU crystals in human-derived synovial membrane (SM) ...MSU crystals trigger an ...
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NLRP3 promotes autophagy of urate crystals phagocytized by human osteoblasts
... To evaluate the fate of MSU in the presence of OBs, live confluent primary human OBs were cultured with graded concentrations of MSU during 7 days. OBs that phagocytized MSU showed, after 48 hours of incubation, ...
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Disease associated particulates and joint inflammation; mechanistic insights and therapeutic targets
... Monosodium urate crystals induce matrix metalloprotease (MMP) expression by chondrocytes (13), prostaglandin, and CCL2 production by fibroblasts and synoviocytes (14) and TGFβ1, IL-6, tumor necrosis factor ...
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A systematic review on the prevalence, pathophysiology, diagnosis, management and treatment of gout (2007-2018)
... Gout is a type of inflammatory arthritis with drastically increasing incidence since last twenty years. Increased serum uric acid levels and deposition of urate crystals in joints and soft tissues are known ...
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Is vitamin C able to reduce hyperuricemia
... of urate crystals in various tissues such as joints, connective tissue, and kidneys explains the chronic character of the ...serum urate normal, joint puncture to demonstrate the presence of ...
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Modulation of monosodium urate crystal induced responses in neutrophils by the myeloid inhibitory C type lectin like receptor: potential therapeutic implications
... Introduction: Monosodium urate crystals (MSU), the etiological agent of gout, are one of the most potent proinflammatory stimuli for neutrophils. The modulation of MSU-induced neutrophil activation by ...
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Inflammatory microcrystals induce murine macrophage survival and DNA synthesis
... BCP crystals can behave similarly, reflecting the fact that BCP and CPPD crystals share many of the fundamental mechanisms of cell activation utilized by urate crystals ...monosodium ...
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Performance of gout definitions for genetic epidemiological studies: analysis of UK Biobank
... monosodium urate crystals as the gold standard for gout definition, reported that the definition of self-report of gout or urate-lowering therapy (ULT) use had the best test performance ...
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UNDERSTANDING GOUT BEYOND DOUBT
... Life is all about movements and activities. Our entire livelihood and existence comes into trouble, we become immobile and inactive due to joint pains and swelling. Gout is one such condition, which affects an ...
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In Vitro Growth and Inhibition Studies of Ceiba Pentandra on Monosodium Urate Monohydrate Crystals
... monosodium urate crystallizes which resulted deposits in joints, tendons, and surrounding ...when crystals of uric acid, i.e. monosodium urate precipitate on the tendons, cartilage of joints and in ...
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