urokinase receptor
Urokinase Receptor Counteracts Vascular Smooth Muscle Cell Functional Changes Induced by Surface Topography
... Current treatments for human coronary artery disease necessitate the development of the next generations of vascular bioimplants. Recent reports provide evidence that controlling cell orien- tation and morphology through ...
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Role of Urokinase Receptor in Tumor Progression and Development
... Elevated level of urokinase receptor (uPAR) is detected in various aggressive cancer types and is closely associated with poor prognosis of cancers. Binding of uPA to uPAR triggers the conversion of ...
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Urinary soluble urokinase receptor levels are elevated and pathogenic in patients with primary focal segmental glomerulosclerosis
... Focal segmental glomerulosclerosis (FSGS), which was first described by Rich in an autopsy series [1], is defined as a clinico-pathological syndrome manifesting with pro- teinuria, usually of nephrotic range, and ...
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The urokinase receptor (CD87) facilitates CD11b/CD18 mediated adhesion of human monocytes
... immunoglobulin receptor Fc g R III (CD16) (11, 12), and the urokinase receptor (uPAR; CD87) ...ligand, urokinase-type plasminogen activator (uPA) ...
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Prostate cancer cells show elevated urokinase receptor in a mouse model of metastasis
... Overall, our in vivo model indicates that there is a selec- tion for prostate cancer cells with high uPAR expression during early stages of successful metastasis. In vitro, high uPAR expression enables prostate tumor ...
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Generation and characterization of urokinase receptor deficient mice
... rophages. This again might be explained by the action of u-PA secreted in the medium during the assay. In addition, the con- tribution of plasminogen-independent proteolytic activity might obscure possible differences ...
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A ligand free, soluble urokinase receptor is present in the ascitic fluid from patients with ovarian cancer
... We have identified a soluble form of the human urokinase plasminogen activator (uPA) receptor (uPAR) in the ascitic fluids from patients with ovarian cancer. After purification of uPAR from the ascitic ...
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The urokinase receptor-derived cyclic peptide [SRSRY] suppresses neovascularization and intravasation of osteosarcoma and chondrosarcoma cells
... The uPAR consists of three domains (D1, D2, and D3), anchored to the cell surface through a carboxy- terminal glycosyl-phosphatidyl-inositol anchor [10]. Full uPAR or fragments thereof (deriving from cleavages at ...
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The urokinase receptor is required for human monocyte chemotaxis in vitro
... Thus, we conclude that blocking uPAR expression on the cell surface with AS-uPAR ablates mononuclear cell chemotaxis to FMLP, while blocking uPA expression has only a relatively small ef[r] ...
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Urokinase receptor is a multifunctional protein: influence of receptor occupancy on macrophage gene expression
... either urokinase or to uPAR that prevent receptor binding inhibited induction of cathepsin B in cultured monocytes and both cathepsin B and 92-kD gelatinase mRNA and protein in phorbol diester-stimulated ...
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Immunohistochemical localization of urokinase-type plasminogen activator, urokinase-type plasminogen activator receptor and α2-antiplasmin in human corneal perforation: a case report
... fibroblasts and cleaved u-PAR (D2D3) is increased in myofibroblasts [14]. The antibody used in our study was made for a C-terminal peptide present both on the intact and cleaved form of the receptor. Therefore, we ...
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Enhanced bioreduction-responsive diselenide-based dimeric prodrug nanoparticles for triple negative breast cancer therapy
... that urokinase-type plasminogen activator receptor (uPAR) plays a major role in invasive cancer cells and also shows high expression in TNBC [32, 33], a uPAR ligand, uPA peptide (sequence: VSNKYFSNIHW) ...
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Correlation of biomarkers for parasite burden and immune activation with acute kidney injury in severe falciparum malaria
... soluble urokinase–type plasminogen activator receptor (suPAR) reflects the systemic level of cell surface urokinase-type plasminogen activator receptor (uPAR) ex- pression, and has been ...
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Plasma soluble vascular endothelial growth factor receptor 1 levels predict outcomes of pneumonia related septic shock patients: a prospective observational study
... factor receptor-1 (sVEGFR1) and urokinase plasminogen activator (uPA) have diverse effects in the pathogenesis of sepsis, which involve pro- inflammation, anti-inflammation, endothelial cell repair, and ...
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UROKINASE RECEPTORS, AND ITS STRUCTURE, SIGNAL TRANSDUCTION AND IMPORTANCE IN ‘PULMONARY RENAL CASCADE’
... Aim: Urokinase is an important and critical enzyme of the Pulmonary renal ...The urokinase-type plasminogen activator (uPA) receptor (uPAR), was identified, isolated and cloned as the plasma membrane ...
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Diagnostic value of decoy receptor 3 combined with procalcitonin and soluble urokinase-type plasminogen activator receptor for sepsis
... Decoy receptor 3 (DcR3) is a new member of the tumor necrosis factor receptors superfamily, which competitively binds Fas ligand, LIGHT and TL1A to block apop- ...
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Be Active or Not: the Relative Contribution of Active and Passive Tumor Targeting of Nanomaterials
... Figure 5. The relative contribution of the EPR effect and receptor-mediated targeting effect to tumor accumulation of NMs. (A) Specific accumulation of both HSA (top panels) and ATF-HSA (bottom panels) in tumors ...
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Use of the prognostic biomarker suPAR in the emergency department improves risk stratification but has no effect on mortality: a cluster-randomized clinical trial (TRIAGE III)
... soluble urokinase plasminogen activator receptor (suPAR) for risk stratification in the emergency department reduces mortality in acutely admitted ...
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Biomarkers of blood cadmium and incidence of cardiovascular events in non-smokers: results from a population-based proteomics study
... factor receptor superfamily member 6; FGF-23: fibroblast growth factor 23; FS: follistatin; GAL: galanin peptides; Gal-3: galec- tin-3; GDF-15: growth/differentiation factor 15; GH: growth hormone; HB-EGF: ...
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Urokinase-type plasminogen activator supports liver repair independent of its cellular receptor
... its receptor may optimize liver cell pro- liferation and repair, the primary functions of fibrin removal, clearance of necrotic cells, and reorganization of the liver lobule can be efficiently accomplished solely ...
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